CL:0000312
From FANTOM5_SSTAR
| Name: | keratinocyte | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, MESH:A.11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] | ||
| Xrefs: |
| ||
| Synonyms: |
"keratinized cell of epidermis" EXACT [] "malpighian cell" EXACT [] | ||
| Comments: | Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. | ||
| Alt_id: | CL:0002185 |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000237(keratinizing barrier epithelial cell),CL:0000362(epidermal cell) |
|---|---|
| part_of: | UBERON:0001003(skin epidermis) |
Children
| is a: | CL:0000242 (Merkel cell) |
|---|---|
| derives from: | FF:0000082 (human epidermal keratinocyte sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10843-111E6 (merkel cell carcinoma cell line:MKL-1)
- 10844-111E7 (merkel cell carcinoma cell line:MS-1)
- 11272-116H3 (Keratinocyte - epidermal, donor1)
- 11349-117G8 (Keratinocyte - epidermal, donor2)
- 11421-118F8 (Keratinocyte - epidermal, donor3)
Mouse (Mus musculus)
- 10843-111E6 (merkel cell carcinoma cell line:MKL-1)
- 10844-111E7 (merkel cell carcinoma cell line:MS-1)
- 11272-116H3 (Keratinocyte - epidermal, donor1)
- 11349-117G8 (Keratinocyte - epidermal, donor2)
- 11421-118F8 (Keratinocyte - epidermal, donor3)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000312 (keratinocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 3.49e-79 | FFCP PHASE1:Hg19::chr4:6356121..6356152,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr4:6356121..6356152, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr15:46610847..46610851,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610847..46610851, + |
| 3.49e-79 | FFCP PHASE1:Hg19::chr11:79659013..79659021,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr11:79659013..79659021, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr22:27043104..27043111,+#_99c4594d4b8c5aea164195d6d4db5672 | p27@MIAT |
| 3.49e-79 | FFCP PHASE1:Hg19::chr1:201288895..201288902,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:201288895..201288902, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr11:79659052..79659060,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr11:79659052..79659060, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr15:46610951..46610964,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610951..46610964, + |
| 3.49e-79 | FFCP PHASE1:Hg19::chr15:46610897..46610904,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610897..46610904, + |
| 3.49e-79 | FFCP PHASE1:Hg19::chr11:79659052..79659060,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr11:79659052..79659060, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr1:216196797..216196801,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:216196797..216196801, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr1:216595350..216595395,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:216595350..216595395, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr1:242843433..242843446,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:242843433..242843446, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr19:39401676..39401683,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr19:39401676..39401683, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr9:139089234..139089236,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr9:139089234..139089236, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr15:46610951..46610964,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610951..46610964, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr5:64369097..64369105,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr5:64369097..64369105, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr6:112466463..112466468,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr6:112466463..112466468, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr1:40770344..40770353,-#_99c4594d4b8c5aea164195d6d4db5672 | p29@COL9A2 |
| 3.49e-79 | FFCP PHASE2:Hg19::chr3:66452082..66452087,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr3:66452082..66452087, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr9:139089234..139089236,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr9:139089234..139089236, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr19:39401676..39401683,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr19:39401676..39401683, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr1:216196797..216196801,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:216196797..216196801, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr20:49727833..49727839,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr20:49727833..49727839, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr5:64369097..64369105,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr5:64369097..64369105, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr9:33719626..33719633,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr9:33719626..33719633, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr15:46610847..46610851,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610847..46610851, + |
| 3.49e-79 | FFCP PHASE1:Hg19::chr1:40770344..40770353,-#_99c4594d4b8c5aea164195d6d4db5672 | p29@COL9A2 |
| 3.49e-79 | FFCP PHASE2:Hg19::chr4:6356121..6356152,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr4:6356121..6356152, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr22:27043104..27043111,+#_99c4594d4b8c5aea164195d6d4db5672 | p27@MIAT |
| 3.49e-79 | FFCP PHASE2:Hg19::chr1:201288895..201288902,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:201288895..201288902, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr11:79659013..79659021,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr11:79659013..79659021, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr6:112466463..112466468,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr6:112466463..112466468, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr1:216595350..216595395,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:216595350..216595395, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr20:49727833..49727839,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr20:49727833..49727839, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr9:33719626..33719633,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr9:33719626..33719633, - |
| 3.49e-79 | FFCP PHASE1:Hg19::chr3:66452082..66452087,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr3:66452082..66452087, - |
| 3.49e-79 | FFCP PHASE2:Hg19::chr15:46610897..46610904,+#_99c4594d4b8c5aea164195d6d4db5672 | p@chr15:46610897..46610904, + |
| 3.49e-79 | FFCP PHASE2:Hg19::chr1:242843433..242843446,-#_99c4594d4b8c5aea164195d6d4db5672 | p@chr1:242843433..242843446, - |
| 7.37e-60 | FFCP PHASE2:Hg19::chr1:16090914..16090925,+#_1465f29bf63f33c8f453141d23de64a4 | p22@FBLIM1 |
| 7.37e-60 | FFCP PHASE1:Hg19::chr1:16090914..16090925,+#_1465f29bf63f33c8f453141d23de64a4 | p22@FBLIM1 |
| 2.19e-53 | FFCP PHASE2:Hg19::chr22:35921483..35921490,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr22:35921483..35921490, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr12:65175253..65175283,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr12:65175253..65175283, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr16:53653257..53653264,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr16:53653257..53653264, - |
| 2.19e-53 | FFCP PHASE2:Hg19::chr9:139096224..139096231,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr9:139096224..139096231, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr1:155048200..155048207,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr1:155048200..155048207, + |
| 2.19e-53 | FFCP PHASE1:Hg19::chr9:33719660..33719671,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr9:33719660..33719671, - |
| 2.19e-53 | FFCP PHASE2:Hg19::chr5:64369069..64369083,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr5:64369069..64369083, + |
| 2.19e-53 | FFCP PHASE1:Hg19::chr9:139096224..139096231,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr9:139096224..139096231, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr22:35921483..35921490,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr22:35921483..35921490, - |
| 2.19e-53 | FFCP PHASE2:Hg19::chr11:128634589..128634606,+#_933a412cd2e4e0f70fee0c69008f9a58 | p14@FLI1 |
| 2.19e-53 | FFCP PHASE1:Hg19::chr5:64369069..64369083,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr5:64369069..64369083, + |
| 2.19e-53 | FFCP PHASE1:Hg19::chr11:128634589..128634606,+#_933a412cd2e4e0f70fee0c69008f9a58 | p14@FLI1 |
| 2.19e-53 | FFCP PHASE2:Hg19::chr5:145722450..145722456,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr5:145722450..145722456, + |
| 2.19e-53 | FFCP PHASE2:Hg19::chr1:155048171..155048179,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr1:155048171..155048179, + |
| 2.19e-53 | FFCP PHASE2:Hg19::chr16:53653257..53653264,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr16:53653257..53653264, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr5:145722450..145722456,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr5:145722450..145722456, + |
| 2.19e-53 | FFCP PHASE2:Hg19::chr12:65175253..65175283,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr12:65175253..65175283, - |
| 2.19e-53 | FFCP PHASE1:Hg19::chr1:155048171..155048179,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr1:155048171..155048179, + |
| 2.19e-53 | FFCP PHASE2:Hg19::chr1:155048200..155048207,+#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr1:155048200..155048207, + |
| 2.19e-53 | FFCP PHASE2:Hg19::chr9:33719660..33719671,-#_933a412cd2e4e0f70fee0c69008f9a58 | p@chr9:33719660..33719671, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr5:14742023..14742037,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:14742023..14742037, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr20:31116333..31116338,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr20:31116333..31116338, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr2:3152671..3152679,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr2:3152671..3152679, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr20:49727891..49727898,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr20:49727891..49727898, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr5:145724630..145724641,+#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:145724630..145724641, + |
| 2.87e-53 | FFCP PHASE2:Hg19::chr5:145724642..145724652,+#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:145724642..145724652, + |
| 2.87e-53 | FFCP PHASE1:Hg19::chr18:13165683..13165695,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr18:13165683..13165695, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr18:13165683..13165695,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr18:13165683..13165695, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr5:145724642..145724652,+#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:145724642..145724652, + |
| 2.87e-53 | FFCP PHASE2:Hg19::chr1:216286476..216286479,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr1:216286476..216286479, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr11:31312513..31312524,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr11:31312513..31312524, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr5:14742023..14742037,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:14742023..14742037, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr12:54786411..54786421,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr12:54786411..54786421, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr1:216286476..216286479,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr1:216286476..216286479, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr20:31116333..31116338,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr20:31116333..31116338, - |
| 2.87e-53 | FFCP PHASE1:Hg19::chr11:31312513..31312524,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr11:31312513..31312524, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr2:3152671..3152679,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr2:3152671..3152679, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr20:49727891..49727898,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr20:49727891..49727898, - |
| 2.87e-53 | FFCP PHASE2:Hg19::chr5:145724630..145724641,+#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr5:145724630..145724641, + |
| 2.87e-53 | FFCP PHASE1:Hg19::chr12:54786411..54786421,-#_4b76e6a62ae2b11b5ccc4f3051325cd5 | p@chr12:54786411..54786421, - |
| 3.74e-53 | FFCP PHASE1:Hg19::chr7:1327611..1327629,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr7:1327611..1327629, + |
| 3.74e-53 | FFCP PHASE2:Hg19::chr3:77121235..77121260,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr3:77121235..77121260, + |
| 3.74e-53 | FFCP PHASE1:Hg19::chr3:77121235..77121260,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr3:77121235..77121260, + |
| 3.74e-53 | FFCP PHASE2:Hg19::chr7:1327587..1327610,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr7:1327587..1327610, + |
| 3.74e-53 | FFCP PHASE1:Hg19::chr7:1327587..1327610,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr7:1327587..1327610, + |
| 3.74e-53 | FFCP PHASE2:Hg19::chr7:1327611..1327629,+#_de4b25e0072976651eb698a0b9b88f38 | p@chr7:1327611..1327629, + |
| 2.98e-45 | FFCP PHASE2:Hg19::chr4:87770202..87770211,-#_59fc133c22e8d2ec5f1de22d7be86a38 | p5@SLC10A6 |
| 2.98e-45 | FFCP PHASE1:Hg19::chr4:87770202..87770211,-#_59fc133c22e8d2ec5f1de22d7be86a38 | p5@SLC10A6 |
| 1.48e-40 | FFCP PHASE1:Hg19::chr3:181980650..181980653,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr3:181980650..181980653, - |
| 1.48e-40 | FFCP PHASE2:Hg19::chr6:91865192..91865202,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr6:91865192..91865202, - |
| 1.48e-40 | FFCP PHASE1:Hg19::chr9:38414152..38414168,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr9:38414152..38414168, - |
| 1.48e-40 | FFCP PHASE1:Hg19::chr2:197081754..197081790,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr2:197081754..197081790, - |
| 1.48e-40 | FFCP PHASE2:Hg19::chr4:132456095..132456124,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr4:132456095..132456124, - |
| 1.48e-40 | FFCP PHASE2:Hg19::chr3:182262882..182262922,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr3:182262882..182262922, - |
| 1.48e-40 | FFCP PHASE1:Hg19::chr16:81253986..81254016,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p10@PKD1L2 |
| 1.48e-40 | FFCP PHASE2:Hg19::chr16:81253986..81254016,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p10@PKD1L2 |
| 1.48e-40 | FFCP PHASE1:Hg19::chr18:77543021..77543032,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr18:77543021..77543032, - |
| 1.48e-40 | FFCP PHASE2:Hg19::chr18:77543021..77543032,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr18:77543021..77543032, - |
| 1.48e-40 | FFCP PHASE2:Hg19::chr20:49727900..49727904,-#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr20:49727900..49727904, - |
| 1.48e-40 | FFCP PHASE1:Hg19::chr1:3844945..3844991,+#_3a34ab249a6468dcc3fda4d3290bfe32 | p@chr1:3844945..3844991, + |
