CL:0000632
From FANTOM5_SSTAR
Name: | hepatic stellate cell | |
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Namespace: | FANTOM | |
Definition: | "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] | |
Xrefs: |
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Synonyms: |
"fat-storing cell" RELATED [] "hepatic perisinusoidal cell" EXACT [] "ito cell" EXACT [] "lipocyte" RELATED [] "perisinusoidal cell" EXACT [] "vitamin A-storing cells" RELATED [PMID:12808230] | |
Comments: | Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
is_a: | CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell) |
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part_of: | UBERON:0002107(liver) |
Children
is a: | FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1) |
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derives from: | FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
... further results Mouse (Mus musculus)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data