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CL:0000632

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Name:hepatic stellate cell
Namespace:FANTOM
Definition:"A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
Xrefs:
links:

BTO:0002741

FMA:67763
Synonyms: "fat-storing cell" RELATED []
"hepatic perisinusoidal cell" EXACT []
"ito cell" EXACT []
"lipocyte" RELATED []
"perisinusoidal cell" EXACT []
"vitamin A-storing cells" RELATED [PMID:12808230]
Comments:Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell)
part_of:UBERON:0002107(liver)



Children


is a:FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1)
derives from:FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample)

Ontology Tree: Loaded from BioPortal

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FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data