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Coexpression cluster:C41

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Full id: C41_retina_eye_medulla_Retinal_medulloblastoma_kidney_pineal



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
2.67418142040755e-060.000846378419558991429Phototransduction (KEGG):04744
0.0003085105422428410.0390574346479436339Vitamin A and carotenoid metabolism (Wikipathways):WP716
1.11054433107064e-077.02974561567715e-0511401Transmembrane transport of small molecules (Reactome):REACT_15518
0.0002789151934630150.03905743464794366265Axon guidance (Reactome):REACT_18266
2.42202453492495e-050.00511047176869165317{CNGB1,17} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007601visual perception9.81064457375546e-31
GO:0050953sensory perception of light stimulus9.81064457375546e-31
GO:0032501multicellular organismal process3.08510962248049e-22
GO:0007600sensory perception3.26189058192588e-17
GO:0003008system process1.26111358163529e-16
GO:0050877neurological system process1.26111358163529e-16
GO:0044459plasma membrane part1.78753219018382e-10
GO:0005887integral to plasma membrane3.48236554855786e-09
GO:0031226intrinsic to plasma membrane3.82694137065199e-09
GO:0005886plasma membrane1.10604557177807e-08
GO:0009584detection of visible light1.14514516990045e-08
GO:0009583detection of light stimulus1.21800691734385e-08
GO:0016020membrane1.21800691734385e-08
GO:0051606detection of stimulus5.28086257607399e-08
GO:0009416response to light stimulus5.38462326854317e-08
GO:0009582detection of abiotic stimulus5.65792470998684e-08
GO:0050906detection of stimulus during sensory perception6.11213327574056e-08
GO:0009581detection of external stimulus9.71823187771387e-08
GO:0016021integral to membrane1.18976350754503e-07
GO:0031224intrinsic to membrane1.37309308415663e-07
GO:0009314response to radiation1.83030242100536e-07
GO:0051179localization2.5065367989969e-07
GO:0044425membrane part2.61038036091781e-07
GO:0022857transmembrane transporter activity2.74197624924218e-07
GO:0007602phototransduction2.87293679057931e-07
GO:0050962detection of light stimulus during sensory perception3.74486102475781e-07
GO:0050908detection of light stimulus during visual perception3.74486102475781e-07
GO:0006811ion transport5.92245011953541e-07
GO:0022892substrate-specific transporter activity7.77852834846723e-07
GO:0006810transport1.75099921659154e-06
GO:0015075ion transmembrane transporter activity2.18226246992338e-06
GO:0022891substrate-specific transmembrane transporter activity2.48960658892293e-06
GO:0051234establishment of localization3.37262948252363e-06
GO:0009628response to abiotic stimulus3.37262948252363e-06
GO:0031404chloride ion binding7.22496996755269e-06
GO:0043168anion binding7.22496996755269e-06
GO:0000267cell fraction3.39085306567683e-05
GO:0044464cell part7.74935097155196e-05
GO:0006776vitamin A metabolic process0.000113042067013674
GO:0006775fat-soluble vitamin metabolic process0.000196630872701977
GO:0008509anion transmembrane transporter activity0.000213168768062022
GO:0006820anion transport0.000236212476668935
GO:0043195terminal button0.000571118476344432
GO:0033267axon part0.000571118476344432
GO:0005216ion channel activity0.000640543268030827
GO:0005624membrane fraction0.000640982667833571
GO:0022838substrate specific channel activity0.000671170630792134
GO:0022803passive transmembrane transporter activity0.000697600840236669
GO:0015267channel activity0.000697600840236669
GO:0005254chloride channel activity0.000697600840236669
GO:0016323basolateral plasma membrane0.000787400292004814
GO:0007275multicellular organismal development0.00114432280767387
GO:0019867outer membrane0.00121832200935113
GO:0005253anion channel activity0.00140117869902976
GO:0042461photoreceptor cell development0.00211882511925589
GO:0015291secondary active transmembrane transporter activity0.00314933029047855
GO:0046530photoreceptor cell differentiation0.00327547442681604
GO:0048856anatomical structure development0.00372423861523655
GO:0015293symporter activity0.00379722704385757
GO:0005640nuclear outer membrane0.00379722704385757
GO:0030594neurotransmitter receptor activity0.0046305457777339
GO:0048513organ development0.00494388874763118
GO:0042165neurotransmitter binding0.00498385539098099
GO:0048731system development0.00522720437998141
GO:0032502developmental process0.00527176699239718
GO:0045211postsynaptic membrane0.00527176699239718
GO:0044456synapse part0.00694711151701581
GO:0045178basal part of cell0.00704584335409783
GO:0015711organic anion transport0.00704584335409783
GO:0009925basal plasma membrane0.00704584335409783
GO:0005509calcium ion binding0.00769302195183634
GO:0015629actin cytoskeleton0.00776742014550554
GO:0007166cell surface receptor linked signal transduction0.0107349223375345
GO:0015464acetylcholine receptor activity0.0113398407270675
GO:0018298protein-chromophore linkage0.0113398407270675
GO:0022804active transmembrane transporter activity0.0113398407270675
GO:0006766vitamin metabolic process0.0113830076079591
GO:0042166acetylcholine binding0.0120582613735087
GO:0031968organelle outer membrane0.013898647321435
GO:0009887organ morphogenesis0.0170094158627189
GO:0009953dorsal/ventral pattern formation0.0187450992181296
GO:0001709cell fate determination0.0187450992181296
GO:0021902commitment of a neuronal cell to a specific type of neuron in the forebrain0.0187450992181296
GO:0051450myoblast proliferation0.0187450992181296
GO:0015129lactate transmembrane transporter activity0.0187450992181296
GO:0021877forebrain neuron fate commitment0.0187450992181296
GO:0047173phosphatidylcholine-retinol O-acyltransferase activity0.0187450992181296
GO:0015727lactate transport0.0187450992181296
GO:0005008hepatocyte growth factor receptor activity0.0187450992181296
GO:0009288flagellin-based flagellum0.0187450992181296
GO:0033130acetylcholine receptor binding0.0187450992181296
GO:0048012hepatocyte growth factor receptor signaling pathway0.0187450992181296
GO:0006649phospholipid transfer to membrane0.0187450992181296
GO:0009642response to light intensity0.0187450992181296
GO:0005548phospholipid transporter activity0.0209281533410604
GO:0005507copper ion binding0.0219957603073038
GO:0019861flagellum0.0228745297614298
GO:0030424axon0.0228745297614298
GO:0007389pattern specification process0.0250956803577066
GO:0001764neuron migration0.0250956803577066
GO:0000904cellular morphogenesis during differentiation0.025757485968105
GO:0015698inorganic anion transport0.0263006760497974
GO:0005230extracellular ligand-gated ion channel activity0.0279803275485031
GO:0006939smooth muscle contraction0.0279803275485031
GO:0004890GABA-A receptor activity0.0279803275485031
GO:0009605response to external stimulus0.02979352862017
GO:0007420brain development0.0306076284339457
GO:0021872generation of neurons in the forebrain0.0306076284339457
GO:0021798forebrain dorsal/ventral pattern formation0.0306076284339457
GO:0007468regulation of rhodopsin gene expression0.0306076284339457
GO:0022612gland morphogenesis0.0306076284339457
GO:000550211-cis retinal binding0.0306076284339457
GO:0021879forebrain neuron differentiation0.0306076284339457
GO:0008525phosphatidylcholine transmembrane transporter activity0.0306076284339457
GO:0007435salivary gland morphogenesis0.0306076284339457
GO:0043176amine binding0.0319321797904677
GO:0008324cation transmembrane transporter activity0.0319321797904677
GO:0044463cell projection part0.0355698893762162
GO:0016917GABA receptor activity0.0355698893762162
GO:0005328neurotransmitter:sodium symporter activity0.0397857995950336
GO:0004167dopachrome isomerase activity0.041246130335252
GO:0008273calcium, potassium:sodium antiporter activity0.041246130335252
GO:0005594collagen type IX0.041246130335252
GO:0017147Wnt-protein binding0.041246130335252
GO:0043288apocarotenoid metabolic process0.041246130335252
GO:0042574retinal metabolic process0.041246130335252
GO:0046873metal ion transmembrane transporter activity0.041246130335252
GO:0005326neurotransmitter transporter activity0.041246130335252
GO:0019748secondary metabolic process0.041246130335252
GO:0022834ligand-gated channel activity0.041246130335252
GO:0015276ligand-gated ion channel activity0.041246130335252
GO:0022836gated channel activity0.042059685265673



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
eye4.86e-2021
visual system4.86e-2021
retina7.67e-186
photoreceptor array7.67e-186
posterior segment of eyeball7.67e-186
sense organ1.03e-1724
sensory system1.03e-1724
entire sense organ system1.03e-1724


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10
MA0004.10.0348625
MA0006.10.00113926
MA0007.10.484013
MA0009.10.270602
MA0014.19.64327e-17
MA0017.10.486156
MA0019.10.0449111
MA0024.10.000553453
MA0025.11.87176
MA0027.10.834963
MA0028.15.79507e-06
MA0029.10.0327174
MA0030.10.569594
MA0031.10.464404
MA0038.10.522518
MA0040.10.219266
MA0041.10.653569
MA0042.10.521206
MA0043.11.03782
MA0046.10.746526
MA0048.10.000851564
MA0050.10.120399
MA0051.10.0766954
MA0052.10.659947
MA0055.17.08471e-06
MA0056.10
MA0057.10.0048347
MA0058.10.0618966
MA0059.10.189267
MA0060.11.37861e-05
MA0061.10.000947203
MA0063.10
MA0066.11.70153
MA0067.10.0179499
MA0068.10.688394
MA0069.10.0115311
MA0070.10.128795
MA0071.15.59304
MA0072.17.59554
MA0073.10
MA0074.10.612814
MA0076.15.51051e-06
MA0077.10.311043
MA0078.10.84789
MA0081.10.439498
MA0083.10.433528
MA0084.10.46912
MA0087.10.472437
MA0088.10.075902
MA0089.10
MA0090.10.714797
MA0091.11.03892
MA0092.11.88358
MA0093.10.0240352
MA0095.10
MA0098.10
MA0100.10.00102723
MA0101.10.0389069
MA0103.10.371904
MA0105.18.64018e-06
MA0106.10.225275
MA0107.10.00432093
MA0108.20.968046
MA0109.10
MA0111.10.287613
MA0113.11.09366
MA0114.10.219503
MA0115.10.71765
MA0116.10.0606111
MA0117.10.0588096
MA0119.10.471183
MA0122.10.421142
MA0124.11.17086
MA0125.13.46376
MA0130.10
MA0131.10.000487246
MA0132.10
MA0133.10
MA0135.10.703851
MA0136.10.0935381
MA0139.10.00183819
MA0140.10.399173
MA0141.11.33084
MA0142.10.473887
MA0143.10.754429
MA0144.10.0108852
MA0145.10.01965
MA0146.14.00678e-14
MA0147.10.00971543
MA0148.10.130145
MA0149.10.00458314
MA0062.23.57123e-10
MA0035.20.734422
MA0039.20
MA0138.20.103015
MA0002.20.168969
MA0137.20.00983172
MA0104.20.00714375
MA0047.20.350309
MA0112.20.0833173
MA0065.20.0932852
MA0150.11.98929
MA0151.10
MA0152.10.53999
MA0153.10.339102
MA0154.10.153529
MA0155.10.00724831
MA0156.10.0251509
MA0157.10.367716
MA0158.10
MA0159.11.26426
MA0160.10.981074
MA0161.10
MA0162.10
MA0163.10.00065889
MA0164.11.41285
MA0080.20.048576
MA0018.20.0123348
MA0099.20.0142083
MA0079.20
MA0102.20.0713204
MA0258.11.65345
MA0259.12.83285e-06
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data