DOID:1240

Name:	leukemia
Namespace:	FANTOM
Definition:	"A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells." [url:http://en.wikipedia.org/wiki/Leukemia]
Xrefs:	links: ICD9CM:208 ICD9CM:208.9 MSH:D007938 NCI:C3161 SNOMEDCT_2010_1_31:154598008 SNOMEDCT_2010_1_31:188762002 SNOMEDCT_2010_1_31:188767008 SNOMEDCT_2010_1_31:190024009 SNOMEDCT_2010_1_31:190025005 SNOMEDCT_2010_1_31:190029004 SNOMEDCT_2010_1_31:190071003 SNOMEDCT_2010_1_31:255049003 SNOMEDCT_2010_1_31:87163000 SNOMEDCT_2010_1_31:93143009 UMLS_CUI:C0023418
Alt_id:	DOID:9145

Ontology association<br>Each term has an is_a parent in the Disease Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to DISEASE ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	DOID:2531(hematologic cancer)

Children

is a:	DOID:1036 (chronic leukemia),DOID:1037 (lymphoblastic leukemia),DOID:12603 (acute leukemia),DOID:8692 (myeloid leukemia)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples

Human (Homo sapiens)

• 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
• 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
• 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
• 10409-106B4 (chronic myelogenous leukemia cell line:KU812)
• 10416-106C2 (chronic lymphocytic leukemia (T-CLL) cell line:SKW-3)
• 10421-106C7 (adult T-cell leukemia cell line:ATN-1)
• 10429-106D6 (acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL)
• 10454-106G4 (chronic myelogenous leukemia cell line:K562)
• 10455-106G5 (acute lymphoblastic leukemia (B-ALL) cell line:BALL-1)
• 10464-106H5 (acute lymphoblastic leukemia (T-ALL) cell line:Jurkat)

... further results Mouse (Mus musculus)

• 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
• 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
• 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
• 10409-106B4 (chronic myelogenous leukemia cell line:KU812)
• 10416-106C2 (chronic lymphocytic leukemia (T-CLL) cell line:SKW-3)
• 10421-106C7 (adult T-cell leukemia cell line:ATN-1)
• 10429-106D6 (acute lymphoblastic leukemia (T-ALL) cell line:HPB-ALL)
• 10454-106G4 (chronic myelogenous leukemia cell line:K562)
• 10455-106G5 (acute lymphoblastic leukemia (B-ALL) cell line:BALL-1)
• 10464-106H5 (acute lymphoblastic leukemia (T-ALL) cell line:Jurkat)

... further results

Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with DOID:1240 (leukemia), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
3.78e-103	FFCP PHASE2:Hg19::chr6:135513595..135513617,+	p4@MYB
3.78e-103	FFCP PHASE1:Hg19::chr6:135513595..135513617,+	p4@MYB
7.48e-96	FFCP PHASE2:Hg19::chr12:58329776..58329791,-	p3@ENST00000547492
7.48e-96	FFCP PHASE1:Hg19::chr12:58329776..58329791,-	p3@ENST00000547492
6.39e-95	FFCP PHASE1:Hg19::chr16:29674970..29675007,+	p4@SPN
6.39e-95	FFCP PHASE2:Hg19::chr16:29674970..29675007,+	p4@SPN
3.4e-94	FFCP PHASE1:Hg19::chr6:68598314..68598325,-	p@chr6:68598314..68598325, -
3.4e-94	FFCP PHASE2:Hg19::chr6:68598314..68598325,-	p@chr6:68598314..68598325, -
2.68e-92	FFCP PHASE1:Hg19::chr12:58329793..58329806,-	p2@ENST00000547492
2.68e-92	FFCP PHASE2:Hg19::chr12:58329793..58329806,-	p2@ENST00000547492
4.68e-91	FFCP PHASE1:Hg19::chr6:68598272..68598298,-	p@chr6:68598272..68598298, -
4.68e-91	FFCP PHASE2:Hg19::chr6:68598272..68598298,-	p@chr6:68598272..68598298, -
2.96e-89	FFCP PHASE2:Hg19::chr6:68596384..68596400,-	p@chr6:68596384..68596400, -
2.96e-89	FFCP PHASE1:Hg19::chr6:68596384..68596400,-	p@chr6:68596384..68596400, -
1.58e-86	FFCP PHASE1:Mm9::chr10:76688454..76688462,+	p@chr10:76688454..76688462, +
1.58e-86	FFCP PHASE2:Mm9::chr10:76688454..76688462,+	p@chr10:76688454..76688462, +
1.58e-86	FFCP PHASE1:Mm9::chr11:102331415..102331424,-	p9@Itga2b
1.58e-86	FFCP PHASE1:Mm9::chr10:76688464..76688474,+	p@chr10:76688464..76688474, +
1.58e-86	FFCP PHASE2:Mm9::chr10:76688464..76688474,+	p@chr10:76688464..76688474, +
1.58e-86	FFCP PHASE2:Mm9::chr11:102331415..102331424,-	p9@Itga2b
1.84e-86	FFCP PHASE1:Hg19::chr12:58329762..58329773,-	p5@ENST00000547492
1.84e-86	FFCP PHASE2:Hg19::chr12:58329762..58329773,-	p5@ENST00000547492
1.62e-85	FFCP PHASE2:Hg19::chr6:135533394..135533403,+	p@chr6:135533394..135533403, +
1.62e-85	FFCP PHASE1:Hg19::chr6:135533394..135533403,+	p@chr6:135533394..135533403, +
3.6e-85	FFCP PHASE1:Hg19::chr6:68592986..68593000,-	p@chr6:68592986..68593000, -
3.6e-85	FFCP PHASE2:Hg19::chr6:68592986..68593000,-	p@chr6:68592986..68593000, -
3.77e-85	FFCP PHASE2:Hg19::chr6:68598245..68598268,-	p@chr6:68598245..68598268, -
3.77e-85	FFCP PHASE1:Hg19::chr6:68598245..68598268,-	p@chr6:68598245..68598268, -
1.61e-84	FFCP PHASE1:Hg19::chr6:68598507..68598519,-	p@chr6:68598507..68598519, -
1.61e-84	FFCP PHASE2:Hg19::chr6:68598507..68598519,-	p@chr6:68598507..68598519, -
2.52e-84	FFCP PHASE2:Hg19::chr6:68598587..68598598,-	p@chr6:68598587..68598598, -
2.52e-84	FFCP PHASE1:Hg19::chr6:68598587..68598598,-	p@chr6:68598587..68598598, -
5.25e-84	FFCP PHASE1:Hg19::chr16:29675010..29675041,+	p5@SPN
5.25e-84	FFCP PHASE2:Hg19::chr16:29675010..29675041,+	p5@SPN
2.83e-80	FFCP PHASE1:Hg19::chr19:695494..695510,-	p3@PRSS57
2.83e-80	FFCP PHASE2:Hg19::chr19:695494..695510,-	p3@PRSS57
5.88e-80	FFCP PHASE2:Hg19::chr11:33913475..33913549,-	p5@LMO2
5.88e-80	FFCP PHASE1:Hg19::chr11:33913475..33913549,-	p5@LMO2
1.29e-79	FFCP PHASE1:Hg19::chr6:68591611..68591627,-	p@chr6:68591611..68591627, -
1.29e-79	FFCP PHASE2:Hg19::chr6:68593536..68593560,-	p@chr6:68593536..68593560, -
1.29e-79	FFCP PHASE1:Hg19::chr6:68593536..68593560,-	p@chr6:68593536..68593560, -
1.29e-79	FFCP PHASE2:Hg19::chr6:68591611..68591627,-	p@chr6:68591611..68591627, -
2.09e-79	FFCP PHASE1:Hg19::chr6:68597599..68597612,-	p@chr6:68597599..68597612, -
2.09e-79	FFCP PHASE1:Hg19::chr6:68596698..68596715,-	p@chr6:68596698..68596715, -
2.09e-79	FFCP PHASE2:Hg19::chr6:68596826..68596859,-	p@chr6:68596826..68596859, -
2.09e-79	FFCP PHASE2:Hg19::chr6:68597599..68597612,-	p@chr6:68597599..68597612, -
2.09e-79	FFCP PHASE2:Hg19::chr6:68596698..68596715,-	p@chr6:68596698..68596715, -
2.09e-79	FFCP PHASE1:Hg19::chr6:68596826..68596859,-	p@chr6:68596826..68596859, -
1.93e-78	FFCP PHASE1:Hg19::chr6:135502472..135502489,+	p3@MYB
1.93e-78	FFCP PHASE2:Hg19::chr6:135502472..135502489,+	p3@MYB
2.09e-77	FFCP PHASE1:Hg19::chr1:202129105..202129140,-	p2@PTPN7
2.09e-77	FFCP PHASE2:Hg19::chr1:202129105..202129140,-	p2@PTPN7
7.47e-77	FFCP PHASE1:Hg19::chr11:17297848..17297868,+	p9@NUCB2
7.47e-77	FFCP PHASE2:Hg19::chr11:17297848..17297868,+	p9@NUCB2
1.06e-74	FFCP PHASE2:Hg19::chr6:68593520..68593534,-	p@chr6:68593520..68593534, -
1.06e-74	FFCP PHASE2:Hg19::chr6:68595369..68595417,-	p@chr6:68595369..68595417, -
1.06e-74	FFCP PHASE1:Hg19::chr6:68593520..68593534,-	p@chr6:68593520..68593534, -
1.06e-74	FFCP PHASE1:Hg19::chr6:68595369..68595417,-	p@chr6:68595369..68595417, -
1.7e-74	FFCP PHASE2:Hg19::chr6:68596783..68596797,-	p@chr6:68596783..68596797, -
1.7e-74	FFCP PHASE2:Hg19::chr6:68596343..68596355,-	p@chr6:68596343..68596355, -
1.7e-74	FFCP PHASE1:Hg19::chr6:68596343..68596355,-	p@chr6:68596343..68596355, -
1.7e-74	FFCP PHASE1:Hg19::chr6:68596783..68596797,-	p@chr6:68596783..68596797, -
6.82e-72	FFCP PHASE2:Hg19::chr3:18020982..18021001,+	p@chr3:18020982..18021001, +
6.82e-72	FFCP PHASE1:Hg19::chr3:18020982..18021001,+	p@chr3:18020982..18021001, +
1.36e-71	FFCP PHASE1:Hg19::chr22:50523908..50523925,-	p8@MLC1
1.36e-71	FFCP PHASE2:Hg19::chr22:50523908..50523925,-	p8@MLC1
1.62e-71	FFCP PHASE1:Hg19::chr19:695467..695482,-	p2@PRSS57
1.62e-71	FFCP PHASE2:Hg19::chr19:695467..695482,-	p2@PRSS57
5.58e-71	FFCP PHASE1:Hg19::chr6:135516978..135516993,+	p7@MYB
5.58e-71	FFCP PHASE2:Hg19::chr6:135516978..135516993,+	p7@MYB
8.11e-71	FFCP PHASE1:Hg19::chr6:68598984..68598997,-	p2@uc003pes.1, p2@uc003pet.1
8.11e-71	FFCP PHASE2:Hg19::chr6:68598984..68598997,-	p2@uc003pes.1, p2@uc003pet.1
2.97e-70	FFCP PHASE1:Hg19::chr6:68596289..68596302,-	p@chr6:68596289..68596302, -
2.97e-70	FFCP PHASE2:Hg19::chr6:68596289..68596302,-	p@chr6:68596289..68596302, -
3.0e-70	FFCP PHASE1:Hg19::chr1:202130702..202130728,-	p3@PTPN7
3.0e-70	FFCP PHASE2:Hg19::chr1:202130702..202130728,-	p3@PTPN7
6.05e-70	FFCP PHASE1:Hg19::chr6:68599042..68599067,-	p1@uc003pes.1, p1@uc003pet.1
6.05e-70	FFCP PHASE2:Hg19::chr6:68599042..68599067,-	p1@uc003pes.1, p1@uc003pet.1
8.49e-70	FFCP PHASE2:Hg19::chr6:68592948..68592958,-	p@chr6:68592948..68592958, -
8.49e-70	FFCP PHASE1:Hg19::chr6:68592948..68592958,-	p@chr6:68592948..68592958, -
8.92e-70	FFCP PHASE1:Hg19::chr6:68598534..68598555,-	p@chr6:68598534..68598555, -
8.92e-70	FFCP PHASE2:Hg19::chr6:68598534..68598555,-	p@chr6:68598534..68598555, -
9.84e-70	FFCP PHASE1:Hg19::chr6:68593264..68593275,-	p@chr6:68593264..68593275, -
9.84e-70	FFCP PHASE2:Hg19::chr6:68593264..68593275,-	p@chr6:68593264..68593275, -
1.35e-69	FFCP PHASE2:Hg19::chr6:68597438..68597450,-	p@chr6:68597438..68597450, -
1.35e-69	FFCP PHASE1:Hg19::chr6:68596757..68596769,-	p@chr6:68596757..68596769, -
1.35e-69	FFCP PHASE2:Hg19::chr6:68593587..68593600,-	p@chr6:68593587..68593600, -
1.35e-69	FFCP PHASE1:Hg19::chr6:68597438..68597450,-	p@chr6:68597438..68597450, -
1.35e-69	FFCP PHASE2:Hg19::chr6:68593250..68593259,-	p@chr6:68593250..68593259, -
1.35e-69	FFCP PHASE1:Hg19::chr6:68593587..68593600,-	p@chr6:68593587..68593600, -
1.35e-69	FFCP PHASE2:Hg19::chr6:68596757..68596769,-	p@chr6:68596757..68596769, -
1.35e-69	FFCP PHASE1:Hg19::chr6:68593250..68593259,-	p@chr6:68593250..68593259, -
4.05e-69	FFCP PHASE2:Hg19::chr8:130560752..130560768,-	p@chr8:130560752..130560768, -
4.05e-69	FFCP PHASE1:Hg19::chr8:130560752..130560768,-	p@chr8:130560752..130560768, -
1.38e-67	FFCP PHASE2:Hg19::chr6:135526382..135526388,+	p@chr6:135526382..135526388, +
1.38e-67	FFCP PHASE1:Hg19::chr6:135526382..135526388,+	p@chr6:135526382..135526388, +
3.05e-67	FFCP PHASE2:Hg19::chr16:89043605..89043625,-	p6@CBFA2T3
3.05e-67	FFCP PHASE1:Hg19::chr16:89043605..89043625,-	p6@CBFA2T3
7.28e-67	FFCP PHASE1:Hg19::chr12:58329689..58329704,-	p4@ENST00000547492
7.28e-67	FFCP PHASE2:Hg19::chr12:58329689..58329704,-	p4@ENST00000547492

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