MCL coexpression mm9:155
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042254 | ribosome biogenesis and assembly | 1.00013597454651e-12 |
| GO:0022613 | ribonucleoprotein complex biogenesis and assembly | 3.61177819270213e-11 |
| GO:0016072 | rRNA metabolic process | 1.62462010528162e-08 |
| GO:0006364 | rRNA processing | 1.62462010528162e-08 |
| GO:0005634 | nucleus | 4.56303732299683e-06 |
| GO:0010467 | gene expression | 3.10161958225887e-05 |
| GO:0003723 | RNA binding | 6.22388570224254e-05 |
| GO:0030529 | ribonucleoprotein complex | 0.000170816863319853 |
| GO:0006996 | organelle organization and biogenesis | 0.000170816863319853 |
| GO:0043229 | intracellular organelle | 0.000171792290831652 |
| GO:0043226 | organelle | 0.000171792290831652 |
| GO:0006396 | RNA processing | 0.000392453499792763 |
| GO:0006412 | translation | 0.00114282554772659 |
| GO:0043231 | intracellular membrane-bound organelle | 0.00124496728621528 |
| GO:0043227 | membrane-bound organelle | 0.00124496728621528 |
| GO:0044424 | intracellular part | 0.0014898188539095 |
| GO:0003735 | structural constituent of ribosome | 0.00179559093047457 |
| GO:0005840 | ribosome | 0.00192713336044085 |
| GO:0033279 | ribosomal subunit | 0.00192713336044085 |
| GO:0016043 | cellular component organization and biogenesis | 0.00204234959259176 |
| GO:0005622 | intracellular | 0.00238014475926356 |
| GO:0016070 | RNA metabolic process | 0.00556516708943367 |
| GO:0009059 | macromolecule biosynthetic process | 0.00564158888009098 |
| GO:0005730 | nucleolus | 0.00731290439283323 |
| GO:0015934 | large ribosomal subunit | 0.0120031896100776 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0132041180727467 |
| GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator | 0.0136787059307971 |
| GO:0030490 | maturation of SSU-rRNA | 0.0136787059307971 |
| GO:0050265 | RNA uridylyltransferase activity | 0.0136787059307971 |
| GO:0043170 | macromolecule metabolic process | 0.0149370948646656 |
| GO:0044249 | cellular biosynthetic process | 0.0159091344868345 |
| GO:0005830 | cytosolic ribosome (sensu Eukaryota) | 0.0201417948554072 |
| GO:0042274 | ribosomal small subunit biogenesis and assembly | 0.020313434972658 |
| GO:0001826 | inner cell mass cell differentiation | 0.020313434972658 |
| GO:0042273 | ribosomal large subunit biogenesis and assembly | 0.020313434972658 |
| GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator | 0.020313434972658 |
| GO:0001560 | regulation of cell growth by extracellular stimulus | 0.020313434972658 |
| GO:0032991 | macromolecular complex | 0.020313434972658 |
| GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex | 0.0270233926871202 |
| GO:0006432 | phenylalanyl-tRNA aminoacylation | 0.0270233926871202 |
| GO:0030684 | preribosome | 0.0270233926871202 |
| GO:0004826 | phenylalanine-tRNA ligase activity | 0.0270233926871202 |
| GO:0030685 | nucleolar preribosome | 0.0270233926871202 |
| GO:0043526 | neuroprotection | 0.0352525252211054 |
| GO:0001825 | blastocyst formation | 0.0418590485762787 |
| GO:0043232 | intracellular non-membrane-bound organelle | 0.0418590485762787 |
| GO:0043228 | non-membrane-bound organelle | 0.0418590485762787 |
| GO:0003676 | nucleic acid binding | 0.0451472474732762 |
| GO:0009058 | biosynthetic process | 0.0460364227298273 |
| GO:0044445 | cytosolic part | 0.0496546276881865 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic cell | 3.33e-14 | 32 |
| hematopoietic oligopotent progenitor cell | 3.33e-14 | 32 |
| hematopoietic stem cell | 3.33e-14 | 32 |
| angioblastic mesenchymal cell | 3.33e-14 | 32 |
| hematopoietic multipotent progenitor cell | 3.33e-14 | 32 |
| nucleate cell | 3.51e-11 | 16 |
| connective tissue cell | 4.03e-10 | 46 |
| mesenchymal cell | 4.03e-10 | 46 |
| hematopoietic lineage restricted progenitor cell | 4.20e-10 | 25 |
| lymphocyte | 3.86e-09 | 13 |
| common lymphoid progenitor | 3.86e-09 | 13 |
| lymphoid lineage restricted progenitor cell | 9.05e-09 | 12 |
| stem cell | 2.72e-08 | 97 |
| T cell | 3.74e-08 | 11 |
| pro-T cell | 3.74e-08 | 11 |
| motile cell | 9.60e-08 | 54 |
| mature alpha-beta T cell | 4.66e-07 | 9 |
| alpha-beta T cell | 4.66e-07 | 9 |
| immature T cell | 4.66e-07 | 9 |
| mature T cell | 4.66e-07 | 9 |
| immature alpha-beta T cell | 4.66e-07 | 9 |
| Ontology term | p-value | n |
|---|---|---|
| connective tissue | 4.03e-10 | 46 |
| hematopoietic system | 5.14e-09 | 45 |
| blood island | 5.14e-09 | 45 |
| hemolymphoid system | 9.81e-09 | 48 |
| immune system | 9.81e-09 | 48 |
| hemopoietic organ | 3.67e-07 | 29 |
| immune organ | 3.67e-07 | 29 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 3.2964 |
| MA0004.1 | 2.44894 |
| MA0006.1 | 3.09178 |
| MA0007.1 | 0.365969 |
| MA0009.1 | 0.137565 |
| MA0014.1 | 1.78353 |
| MA0017.1 | 0.0576737 |
| MA0019.1 | 0.0588475 |
| MA0024.1 | 1.222 |
| MA0025.1 | 0.282065 |
| MA0027.1 | 1.56857 |
| MA0028.1 | 12.5599 |
| MA0029.1 | 0.105371 |
| MA0030.1 | 0.351128 |
| MA0031.1 | 0.308469 |
| MA0038.1 | 0.522404 |
| MA0040.1 | 0.144181 |
| MA0041.1 | 0.00252973 |
| MA0042.1 | 0.00205235 |
| MA0043.1 | 1.06796 |
| MA0046.1 | 0.156939 |
| MA0048.1 | 0.128959 |
| MA0050.1 | 0.146538 |
| MA0051.1 | 0.295556 |
| MA0052.1 | 0.148517 |
| MA0055.1 | 0.288374 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0970412 |
| MA0058.1 | 1.97665 |
| MA0059.1 | 2.9438 |
| MA0060.1 | 1.63614 |
| MA0061.1 | 0.0849529 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0259328 |
| MA0067.1 | 0.363901 |
| MA0068.1 | 0.315448 |
| MA0069.1 | 0.454571 |
| MA0070.1 | 0.143488 |
| MA0071.1 | 0.145644 |
| MA0072.1 | 0.139001 |
| MA0073.1 | 0.000199984 |
| MA0074.1 | 0.216729 |
| MA0076.1 | 17.7815 |
| MA0077.1 | 0.127837 |
| MA0078.1 | 0.150459 |
| MA0081.1 | 1.53932 |
| MA0083.1 | 0.191806 |
| MA0084.1 | 0.637349 |
| MA0087.1 | 0.498602 |
| MA0088.1 | 1.19595 |
| MA0089.1 | 0 |
| MA0090.1 | 0.176187 |
| MA0091.1 | 0.0427098 |
| MA0092.1 | 0.0799772 |
| MA0093.1 | 2.53737 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 1.74594 |
| MA0101.1 | 0.590319 |
| MA0103.1 | 0.0255075 |
| MA0105.1 | 0.645571 |
| MA0106.1 | 0.645595 |
| MA0107.1 | 0.127792 |
| MA0108.2 | 0.509763 |
| MA0109.1 | 0 |
| MA0111.1 | 0.560854 |
| MA0113.1 | 0.574532 |
| MA0114.1 | 0.238773 |
| MA0115.1 | 0.565506 |
| MA0116.1 | 0.163922 |
| MA0117.1 | 0.174766 |
| MA0119.1 | 0.2364 |
| MA0122.1 | 0.186489 |
| MA0124.1 | 0.323825 |
| MA0125.1 | 0.270734 |
| MA0130.1 | 0 |
| MA0131.1 | 2.24263 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.214898 |
| MA0136.1 | 1.49234 |
| MA0139.1 | 4.22676 |
| MA0140.1 | 0.201721 |
| MA0141.1 | 0.652668 |
| MA0142.1 | 0.0863477 |
| MA0143.1 | 0.0371917 |
| MA0144.1 | 0.247755 |
| MA0145.1 | 0.093031 |
| MA0146.1 | 3.984 |
| MA0147.1 | 7.76057 |
| MA0148.1 | 0.256362 |
| MA0149.1 | 0.406861 |
| MA0062.2 | 22.0544 |
| MA0035.2 | 0.0816244 |
| MA0039.2 | 1.67011 |
| MA0138.2 | 0.0547361 |
| MA0002.2 | 0.26171 |
| MA0137.2 | 1.14867 |
| MA0104.2 | 8.08443 |
| MA0047.2 | 0.116955 |
| MA0112.2 | 0.193997 |
| MA0065.2 | 0.0941152 |
| MA0150.1 | 0.204799 |
| MA0151.1 | 0 |
| MA0152.1 | 0.117033 |
| MA0153.1 | 0.640472 |
| MA0154.1 | 0.348726 |
| MA0155.1 | 0.362756 |
| MA0156.1 | 3.77915 |
| MA0157.1 | 0.0735967 |
| MA0158.1 | 0 |
| MA0159.1 | 0.202755 |
| MA0160.1 | 0.261608 |
| MA0161.1 | 0 |
| MA0162.1 | 2.66367 |
| MA0163.1 | 1.14213 |
| MA0164.1 | 0.745201 |
| MA0080.2 | 1.28199 |
| MA0018.2 | 1.54617 |
| MA0099.2 | 0.052724 |
| MA0079.2 | 0.166561 |
| MA0102.2 | 1.63717 |
| MA0258.1 | 0.00370057 |
| MA0259.1 | 3.53761 |
| MA0442.1 | 0 |
