MCL coexpression mm9:327
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005634 | nucleus | 0.00893147018551157 |
| GO:0044424 | intracellular part | 0.00893147018551157 |
| GO:0003723 | RNA binding | 0.00893147018551157 |
| GO:0005622 | intracellular | 0.00893147018551157 |
| GO:0043231 | intracellular membrane-bound organelle | 0.00893147018551157 |
| GO:0043227 | membrane-bound organelle | 0.00893147018551157 |
| GO:0010467 | gene expression | 0.0124184894000314 |
| GO:0003676 | nucleic acid binding | 0.0124184894000314 |
| GO:0003899 | DNA-directed RNA polymerase activity | 0.0124184894000314 |
| GO:0000166 | nucleotide binding | 0.0250303259944819 |
| GO:0043229 | intracellular organelle | 0.0250303259944819 |
| GO:0043226 | organelle | 0.0250303259944819 |
| GO:0032405 | MutLalpha complex binding | 0.0250303259944819 |
| GO:0032407 | MutSalpha complex binding | 0.0250303259944819 |
| GO:0008432 | JUN kinase binding | 0.0250303259944819 |
| GO:0032404 | mismatch repair complex binding | 0.0250303259944819 |
| GO:0042405 | nuclear inclusion body | 0.0250303259944819 |
| GO:0044428 | nuclear part | 0.0250303259944819 |
| GO:0000109 | nucleotide-excision repair complex | 0.034379028864868 |
| GO:0016973 | poly(A)+ mRNA export from nucleus | 0.0395695407995545 |
| GO:0006283 | transcription-coupled nucleotide-excision repair | 0.0395695407995545 |
| GO:0016234 | inclusion body | 0.0395695407995545 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.040060873560071 |
| GO:0016779 | nucleotidyltransferase activity | 0.0418329151080293 |
| GO:0005528 | FK506 binding | 0.0418329151080293 |
| GO:0005527 | macrolide binding | 0.0418329151080293 |
| GO:0043393 | regulation of protein binding | 0.0464582033755782 |
| GO:0008144 | drug binding | 0.0464582033755782 |
| GO:0044238 | primary metabolic process | 0.0464582033755782 |
| GO:0051320 | S phase | 0.0464582033755782 |
| GO:0000084 | S phase of mitotic cell cycle | 0.0464582033755782 |
| GO:0044237 | cellular metabolic process | 0.0464582033755782 |
| GO:0006457 | protein folding | 0.0464582033755782 |
| GO:0005487 | nucleocytoplasmic transporter activity | 0.0496520151209464 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic cell | 1.18e-09 | 32 |
| hematopoietic oligopotent progenitor cell | 1.18e-09 | 32 |
| hematopoietic stem cell | 1.18e-09 | 32 |
| angioblastic mesenchymal cell | 1.18e-09 | 32 |
| hematopoietic multipotent progenitor cell | 1.18e-09 | 32 |
| lymphocyte | 1.84e-08 | 13 |
| common lymphoid progenitor | 1.84e-08 | 13 |
| nucleate cell | 3.12e-08 | 16 |
| lymphoid lineage restricted progenitor cell | 4.86e-08 | 12 |
| T cell | 2.00e-07 | 11 |
| pro-T cell | 2.00e-07 | 11 |
| mature alpha-beta T cell | 7.23e-07 | 9 |
| alpha-beta T cell | 7.23e-07 | 9 |
| immature T cell | 7.23e-07 | 9 |
| mature T cell | 7.23e-07 | 9 |
| immature alpha-beta T cell | 7.23e-07 | 9 |
| Ontology term | p-value | n |
|---|---|---|
| hemopoietic organ | 8.87e-08 | 29 |
| immune organ | 8.87e-08 | 29 |
| anterior region of body | 9.04e-08 | 43 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.87655 |
| MA0004.1 | 0.794862 |
| MA0006.1 | 0.394627 |
| MA0007.1 | 1.23839 |
| MA0009.1 | 0.452863 |
| MA0014.1 | 1.12934 |
| MA0017.1 | 0.452527 |
| MA0019.1 | 0.30302 |
| MA0024.1 | 1.87787 |
| MA0025.1 | 0.660968 |
| MA0027.1 | 2.04174 |
| MA0028.1 | 3.96383 |
| MA0029.1 | 0.397373 |
| MA0030.1 | 0.402861 |
| MA0031.1 | 0.373333 |
| MA0038.1 | 0.220281 |
| MA0040.1 | 0.463641 |
| MA0041.1 | 0.0860551 |
| MA0042.1 | 0.0797095 |
| MA0043.1 | 0.53743 |
| MA0046.1 | 0.483941 |
| MA0048.1 | 0.484222 |
| MA0050.1 | 1.43697 |
| MA0051.1 | 0.643016 |
| MA0052.1 | 0.47061 |
| MA0055.1 | 0.0154442 |
| MA0056.1 | 0 |
| MA0057.1 | 0.430886 |
| MA0058.1 | 0.55981 |
| MA0059.1 | 0.588924 |
| MA0060.1 | 0.447532 |
| MA0061.1 | 0.854791 |
| MA0063.1 | 0 |
| MA0066.1 | 0.212546 |
| MA0067.1 | 0.764133 |
| MA0068.1 | 0.0205783 |
| MA0069.1 | 0.470904 |
| MA0070.1 | 0.462521 |
| MA0071.1 | 0.149369 |
| MA0072.1 | 0.455219 |
| MA0073.1 | 1.49444 |
| MA0074.1 | 1.05068 |
| MA0076.1 | 6.71771 |
| MA0077.1 | 0.436665 |
| MA0078.1 | 0.250627 |
| MA0081.1 | 0.312046 |
| MA0083.1 | 0.536725 |
| MA0084.1 | 1.07765 |
| MA0087.1 | 0.4987 |
| MA0088.1 | 2.47003 |
| MA0089.1 | 0 |
| MA0090.1 | 0.107485 |
| MA0091.1 | 0.418347 |
| MA0092.1 | 0.107655 |
| MA0093.1 | 1.16444 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 3.05515 |
| MA0101.1 | 0.610312 |
| MA0103.1 | 0.218786 |
| MA0105.1 | 1.29467 |
| MA0106.1 | 0.256379 |
| MA0107.1 | 1.22202 |
| MA0108.2 | 0.85894 |
| MA0109.1 | 0 |
| MA0111.1 | 0.744051 |
| MA0113.1 | 0.664215 |
| MA0114.1 | 0.287365 |
| MA0115.1 | 0.539917 |
| MA0116.1 | 0.174756 |
| MA0117.1 | 0.511373 |
| MA0119.1 | 0.0869793 |
| MA0122.1 | 0.528896 |
| MA0124.1 | 0.714453 |
| MA0125.1 | 0.646095 |
| MA0130.1 | 0 |
| MA0131.1 | 3.11389 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.569948 |
| MA0136.1 | 0.583392 |
| MA0139.1 | 1.64741 |
| MA0140.1 | 0.180161 |
| MA0141.1 | 0.0690765 |
| MA0142.1 | 0.361451 |
| MA0143.1 | 0.247626 |
| MA0144.1 | 0.123063 |
| MA0145.1 | 0.45978 |
| MA0146.1 | 2.55888 |
| MA0147.1 | 2.27347 |
| MA0148.1 | 0.136186 |
| MA0149.1 | 0.0894222 |
| MA0062.2 | 5.43258 |
| MA0035.2 | 0.18328 |
| MA0039.2 | 3.29233 |
| MA0138.2 | 0.796689 |
| MA0002.2 | 0.91042 |
| MA0137.2 | 0.514948 |
| MA0104.2 | 2.26352 |
| MA0047.2 | 0.219739 |
| MA0112.2 | 0.295523 |
| MA0065.2 | 0.0863447 |
| MA0150.1 | 0.376372 |
| MA0151.1 | 0 |
| MA0152.1 | 0.62695 |
| MA0153.1 | 0.584906 |
| MA0154.1 | 0.473854 |
| MA0155.1 | 0.354426 |
| MA0156.1 | 0.849859 |
| MA0157.1 | 0.335532 |
| MA0158.1 | 0 |
| MA0159.1 | 0.610644 |
| MA0160.1 | 0.137981 |
| MA0161.1 | 0 |
| MA0162.1 | 2.20629 |
| MA0163.1 | 0.448848 |
| MA0164.1 | 0.201705 |
| MA0080.2 | 0.212388 |
| MA0018.2 | 1.77229 |
| MA0099.2 | 0.288477 |
| MA0079.2 | 1.18287 |
| MA0102.2 | 1.12863 |
| MA0258.1 | 0.26175 |
| MA0259.1 | 1.6899 |
| MA0442.1 | 0 |
