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MCL coexpression mm9:3577

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Phase1 CAGE Peaks

 Short description
Mm9::chr6:83267532..83267582,-p1@Mthfd2
Mm9::chr6:83267583..83267596,-p2@Mthfd2
Mm9::chr7:150785954..150785983,-p1@Cars


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0006520amino acid metabolic process0.00269568024921202
GO:0006423cysteinyl-tRNA aminoacylation0.00269568024921202
GO:0000105histidine biosynthetic process0.00269568024921202
GO:0004488methylenetetrahydrofolate dehydrogenase (NADP+) activity0.00269568024921202
GO:0004817cysteine-tRNA ligase activity0.00269568024921202
GO:0004486methylenetetrahydrofolate dehydrogenase activity0.00269568024921202
GO:0009076histidine family amino acid biosynthetic process0.00269568024921202
GO:0004477methenyltetrahydrofolate cyclohydrolase activity0.00269568024921202
GO:0006519amino acid and derivative metabolic process0.00269568024921202
GO:0009308amine metabolic process0.00328380268959057
GO:0006807nitrogen compound metabolic process0.00345843917185193
GO:0019238cyclohydrolase activity0.00372510883533307
GO:0019752carboxylic acid metabolic process0.00437938331393147
GO:0006082organic acid metabolic process0.00437938331393147
GO:0009396folic acid and derivative biosynthetic process0.00521472373854911
GO:0006555methionine metabolic process0.00525840086881686
GO:0009086methionine biosynthetic process0.00525840086881686
GO:0009075histidine family amino acid metabolic process0.0055864385932362
GO:0006547histidine metabolic process0.0055864385932362
GO:0016646oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor0.0055864385932362
GO:0006760folic acid and derivative metabolic process0.0055864385932362
GO:0000097sulfur amino acid biosynthetic process0.0055864385932362
GO:0000049tRNA binding0.0055864385932362
GO:0009067aspartate family amino acid biosynthetic process0.0055864385932362
GO:0009066aspartate family amino acid metabolic process0.00625646831969079
GO:0000096sulfur amino acid metabolic process0.00687486309335938
GO:0044249cellular biosynthetic process0.00797887704781829
GO:0016645oxidoreductase activity, acting on the CH-NH group of donors0.00797887704781829
GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines0.00885857639858035
GO:0044272sulfur compound biosynthetic process0.0107954166363953
GO:0008652amino acid biosynthetic process0.0123796454361451
GO:0009058biosynthetic process0.0123796454361451
GO:0043038amino acid activation0.0143925238184049
GO:0043039tRNA aminoacylation0.0143925238184049
GO:0006418tRNA aminoacylation for protein translation0.0143925238184049
GO:0016875ligase activity, forming carbon-oxygen bonds0.0143925238184049
GO:0016876ligase activity, forming aminoacyl-tRNA and related compounds0.0143925238184049
GO:0004812aminoacyl-tRNA ligase activity0.0143925238184049
GO:0006752group transfer coenzyme metabolic process0.0153446041292717
GO:0005625soluble fraction0.0153446041292717
GO:0009309amine biosynthetic process0.0159402589561594
GO:0006790sulfur metabolic process0.0159402589561594
GO:0006164purine nucleotide biosynthetic process0.0167345164194997
GO:0046483heterocycle metabolic process0.0167345164194997
GO:0006163purine nucleotide metabolic process0.0182718976133919
GO:0044271nitrogen compound biosynthetic process0.0182718976133919
GO:0006730one-carbon compound metabolic process0.0182718976133919
GO:0009108coenzyme biosynthetic process0.0192821786766828
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0204777483448519
GO:0051188cofactor biosynthetic process0.0214025459163666
GO:0006399tRNA metabolic process0.0218547738660344
GO:0006725aromatic compound metabolic process0.0242123242615664
GO:0009165nucleotide biosynthetic process0.0256411751555361
GO:0006732coenzyme metabolic process0.0327653977682705
GO:0009117nucleotide metabolic process0.0365986452977421
GO:0051186cofactor metabolic process0.0371305140389463
GO:0055086nucleobase, nucleoside and nucleotide metabolic process0.0378373351305979
GO:0032787monocarboxylic acid metabolic process0.0408054310535513
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0444730834121558



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>

Cell Type
Ontology termp-valuen
stem cell4.98e-0997
somatic stem cell1.98e-0791
multi fate stem cell1.98e-0791


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.245953
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.416365
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.11.49373
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.353763
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.10.190475
MA0056.10
MA0057.10.896032
MA0058.10.690848
MA0059.10.705317
MA0060.15.53738
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.343188
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.00834468
MA0074.10.911576
MA0076.11.58243
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.27999
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.11.3296
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.10.462282
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.292366
MA0146.10.151124
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.21.06145
MA0035.20.903829
MA0039.21.55941
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.10.312898
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.964824
MA0163.11.48428
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.20.450051
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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