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Coexpression cluster:C3060: Difference between revisions

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|tf_chipseq_enrich=BATF#10538;3:24.3578017923036:6.91705216281876e-05:0.00109855536927103!FOS#2353;3:8.9979553088944:0.00137249927241713:0.00894716007190391!JUN#3725;3:12.5128291923363:0.000510331399272625:0.00443046558675259
|tf_chipseq_enrich=BATF#10538;3:24.3578017923036:6.91705216281876e-05:0.00109855536927103!FOS#2353;3:8.9979553088944:0.00137249927241713:0.00894716007190391!JUN#3725;3:12.5128291923363:0.000510331399272625:0.00443046558675259
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}}
}}

Revision as of 15:54, 26 November 2012


Full id: C3060_cord_glioblastoma_Fibroblast_adult_Hair_mesenchymal_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr10:95139640..95139659,-p@chr10:95139640..95139659
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Hg19::chr10:95139664..95139690,-p@chr10:95139664..95139690
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Hg19::chr10:95139698..95139709,-p@chr10:95139698..95139709
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell1.79e-19679
eukaryotic cell1.79e-19679
somatic cell1.08e-15588
native cell8.70e-14722
mesodermal cell1.46e-13121
embryonic cell3.54e-12250
fibroblast1.81e-1076
muscle precursor cell1.18e-0858
myoblast1.18e-0858
multi-potent skeletal muscle stem cell1.18e-0858
somatic stem cell5.57e-08433
squamous epithelial cell6.07e-0863
mesothelial cell7.43e-0819
muscle cell1.25e-0755
skin fibroblast1.27e-0723
multi fate stem cell2.23e-07427
stem cell4.54e-07441
preadipocyte6.92e-0712
Uber Anatomy
Ontology termp-valuen
surface structure1.99e-0999
multilaminar epithelium2.45e-0883
integument4.10e-0846
integumental system4.10e-0846
somite5.18e-0871
presomitic mesoderm5.18e-0871
presumptive segmental plate5.18e-0871
dermomyotome5.18e-0871
trunk paraxial mesoderm5.18e-0871
dense mesenchyme tissue5.68e-0873
vasculature6.57e-0878
vascular system6.57e-0878
paraxial mesoderm1.02e-0772
presumptive paraxial mesoderm1.02e-0772
skin of body1.80e-0741
skeletal muscle tissue2.51e-0762
striated muscle tissue2.51e-0762
myotome2.51e-0762
epithelial vesicle3.91e-0778
muscle tissue9.63e-0764
musculature9.63e-0764
musculature of body9.63e-0764
Disease
Ontology termp-valuen
ovarian cancer1.33e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538324.35780179230366.91705216281876e-050.00109855536927103
FOS#235338.99795530889440.001372499272417130.00894716007190391
JUN#3725312.51282919233630.0005103313992726250.00443046558675259



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.