MCL coexpression mm9:369

Phase1 CAGE Peaks

	Short description
Mm9::chr11:120353209..120353235,+	p1@Slc25a10
Mm9::chr11:120353243..120353263,+	p3@Slc25a10
Mm9::chr11:96891239..96891311,+	p1@Scrn2
Mm9::chr13:54167229..54167278,+	p1@Sfxn1
Mm9::chr17:12868652..12868673,-	p4@Slc22a1
Mm9::chr19:44144226..44144277,-	p1@Erlin1
Mm9::chr19:44181916..44181931,-	p2@Chuk
Mm9::chr1:133693960..133693995,+	p1@Pm20d1
Mm9::chr1:13658820..13658853,+	p1@Xkr9
Mm9::chr1:13659082..13659121,+	p@chr1:13659082..13659121 +
Mm9::chr1:169280107..169280196,+	p2@Aldh9a1
Mm9::chr1:169280315..169280365,+	p1@Aldh9a1
Mm9::chr1:169280377..169280380,+	p@chr1:169280377..169280380 +
Mm9::chr1:59030534..59030545,+	p6@Stradb
Mm9::chr1:59030546..59030561,+	p7@Stradb
Mm9::chr1:93339454..93339482,+	p@chr1:93339454..93339482 +
Mm9::chr4:154937907..154937974,+	p1@Nadk
Mm9::chr5:31223940..31223956,+	p4@Khk
Mm9::chr5:31224198..31224239,+	p2@Khk
Mm9::chr5:31224240..31224269,+	p1@Khk
Mm9::chr6:137703123..137703129,+	p2@Dera

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019145	aminobutyraldehyde dehydrogenase activity	0.0359392976497014
GO:0004139	deoxyribose-phosphate aldolase activity	0.0359392976497014
GO:0004454	ketohexokinase activity	0.0359392976497014
GO:0003951	NAD+ kinase activity	0.0461798253473553
GO:0030099	myeloid cell differentiation	0.0461798253473553
GO:0007252	I-kappaB phosphorylation	0.0461798253473553
GO:0008384	IkappaB kinase activity	0.0461798253473553
GO:0009264	deoxyribonucleotide catabolic process	0.0478757600170195
GO:0009437	carnitine metabolic process	0.0478757600170195

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	5.95e-07	25

Uber Anatomy

Ontology term	p-value	n
intestine	2.51e-14	31
gastrointestinal system	4.67e-14	47
abdomen element	1.49e-12	49
abdominal segment element	1.49e-12	49
abdominal segment of trunk	1.49e-12	49
abdomen	1.49e-12	49
exocrine gland	5.11e-12	25
exocrine system	5.11e-12	25
trunk region element	5.15e-12	79
endoderm-derived structure	1.02e-11	118
endoderm	1.02e-11	118
presumptive endoderm	1.02e-11	118
digestive tract diverticulum	1.36e-11	23
sac	1.36e-11	23
digestive system	1.80e-11	116
digestive tract	1.80e-11	116
primitive gut	1.80e-11	116
liver	3.81e-11	22
epithelial sac	3.81e-11	22
digestive gland	3.81e-11	22
epithelium of foregut-midgut junction	3.81e-11	22
anatomical boundary	3.81e-11	22
hepatobiliary system	3.81e-11	22
foregut-midgut junction	3.81e-11	22
hepatic diverticulum	3.81e-11	22
liver primordium	3.81e-11	22
septum transversum	3.81e-11	22
liver bud	3.81e-11	22
subdivision of digestive tract	1.26e-10	114
mucosa	8.29e-10	15
trunk	5.76e-09	90
subdivision of trunk	7.44e-09	66
intestinal mucosa	8.99e-09	13
anatomical wall	8.99e-09	13
wall of intestine	8.99e-09	13
gastrointestinal system mucosa	8.99e-09	13
mesenchyme	2.85e-08	61
entire embryonic mesenchyme	2.85e-08	61
immaterial anatomical entity	3.09e-08	79
organ component layer	2.17e-07	24
trunk mesenchyme	2.47e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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