MCL coexpression mm9:3072

Phase1 CAGE Peaks

	Short description
Mm9::chr16:96583335..96583347,+	p3@Igsf5
Mm9::chr5:64203686..64203777,+	p1@0610040J01Rik
Mm9::chr7:117792331..117792347,-	p@chr7:117792331..117792347 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030165	PDZ domain binding	0.0132580945597984
GO:0019904	protein domain specific binding	0.0216950638251246
GO:0005923	tight junction	0.0216950638251246
GO:0043296	apical junction complex	0.0216950638251246
GO:0016327	apicolateral plasma membrane	0.0216950638251246
GO:0005911	intercellular junction	0.0301320330904509
GO:0009986	cell surface	0.0313373144140689
GO:0016337	cell-cell adhesion	0.0313373144140689

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
epithelial cell	7.15e-10	25
endodermal cell	2.11e-09	20
intestinal epithelial cell	2.93e-08	9
epithelial cell of alimentary canal	2.93e-08	9

Uber Anatomy

Ontology term	p-value	n
digestive system	1.75e-19	116
digestive tract	1.75e-19	116
primitive gut	1.75e-19	116
intestine	4.62e-19	31
gastrointestinal system	6.62e-19	47
endoderm-derived structure	1.15e-18	118
endoderm	1.15e-18	118
presumptive endoderm	1.15e-18	118
subdivision of digestive tract	2.12e-18	114
trunk region element	9.03e-17	79
trunk	9.12e-13	90
mucosa	5.46e-12	15
intestinal mucosa	5.41e-11	13
anatomical wall	5.41e-11	13
wall of intestine	5.41e-11	13
gastrointestinal system mucosa	5.41e-11	13
immaterial anatomical entity	8.55e-11	79
subdivision of trunk	6.71e-10	66
pancreas	8.68e-09	12
exocrine gland	2.36e-08	25
exocrine system	2.36e-08	25
epithelium of mucosa	2.93e-08	9
gastrointestinal system epithelium	2.93e-08	9
intestinal epithelium	2.93e-08	9
digestive tract diverticulum	3.79e-08	23
sac	3.79e-08	23
liver	1.98e-07	22
epithelial sac	1.98e-07	22
digestive gland	1.98e-07	22
epithelium of foregut-midgut junction	1.98e-07	22
anatomical boundary	1.98e-07	22
hepatobiliary system	1.98e-07	22
foregut-midgut junction	1.98e-07	22
hepatic diverticulum	1.98e-07	22
liver primordium	1.98e-07	22
septum transversum	1.98e-07	22
liver bud	1.98e-07	22

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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