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{{Coexpression_clusters
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|full_id=C2977_CD14_Dendritic_serous_Smooth_Basophils_cerebellum_CD34
|id=C2977
|ontology_enrichment_celltype=CL:0002057!1.42e-22!42;CL:0000860!1.90e-20!45;CL:0000738!5.18e-16!140;CL:0002320!9.51e-12!365;CL:0002087!4.71e-11!119;CL:0000134!5.89e-11!358;CL:0002031!2.00e-10!124;CL:0000766!2.02e-10!76;CL:0002371!6.80e-10!591;CL:0000003!7.16e-10!722;CL:0000048!9.11e-10!430;CL:0000723!2.55e-09!436;CL:0000557!2.88e-09!71;CL:0002009!4.47e-09!65;CL:0000034!7.99e-09!444;CL:0000063!8.25e-09!578;CL:0000219!8.27e-09!390;CL:0002194!2.30e-08!63;CL:0000576!2.30e-08!63;CL:0000040!2.30e-08!63;CL:0000559!2.30e-08!63;CL:0000012!4.27e-08!682;CL:0000037!6.27e-08!172;CL:0000566!6.27e-08!172;CL:0000988!8.61e-08!182;CL:0000548!1.18e-07!679;CL:0000004!1.18e-07!679;CL:0000255!1.18e-07!679;CL:0000839!1.24e-07!70;CL:0000144!2.78e-07!625
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002384!2.02e-10!375;UBERON:0002371!3.50e-10!80;UBERON:0001474!3.64e-09!86;UBERON:0004765!3.67e-09!101;UBERON:0001434!3.67e-09!101;UBERON:0002193!1.37e-08!112;UBERON:0002390!2.87e-08!102;UBERON:0003061!2.87e-08!102;UBERON:0002405!1.18e-07!115
}}

Latest revision as of 12:16, 17 September 2013


Full id: C2977_CD14_Dendritic_serous_Smooth_Basophils_cerebellum_CD34



Phase1 CAGE Peaks

Hg19::chr10:112257429..112257447,-p@chr10:112257429..112257447
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Hg19::chr10:112257453..112257476,-p@chr10:112257453..112257476
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Hg19::chr10:112257490..112257512,-p@chr10:112257490..112257512
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.08e-2142
CD14-positive, CD16-negative classical monocyte4.08e-2142
leukocyte7.99e-16136
defensive cell8.18e-1548
phagocyte8.18e-1548
nongranular leukocyte2.87e-11115
myeloid leukocyte4.53e-1172
hematopoietic lineage restricted progenitor cell1.31e-10120
connective tissue cell1.60e-10361
granulocyte monocyte progenitor cell3.90e-1067
macrophage dendritic cell progenitor6.00e-1061
mesenchymal cell8.96e-10354
somatic cell2.56e-09588
monopoietic cell3.06e-0959
monocyte3.06e-0959
monoblast3.06e-0959
promonocyte3.06e-0959
native cell4.05e-09722
myeloid lineage restricted progenitor cell1.81e-0866
multi fate stem cell2.40e-08427
somatic stem cell6.68e-08433
motile cell7.21e-08386
hematopoietic stem cell1.03e-07168
angioblastic mesenchymal cell1.03e-07168
stem cell1.67e-07441
hematopoietic cell2.45e-07177
animal cell2.63e-07679
eukaryotic cell2.63e-07679
Uber Anatomy
Ontology termp-valuen
bone marrow5.66e-1176
immune system1.93e-1093
skeletal system7.12e-10100
bone element9.65e-1082
connective tissue2.29e-09371
skeletal element7.81e-0990
hemolymphoid system3.43e-08108
hematopoietic system4.37e-0898
blood island4.37e-0898


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.12.44638
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.122.1963
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.13.83913
MA0103.10.628063
MA0105.13.21605
MA0106.10.986396
MA0107.12.34614
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.22.96208
MA0035.20.894194
MA0039.25.50873
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.22.07067
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.387745
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.20.902716
MA0079.21.90288
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189015886083728
E2F1#186934.907389214879320.008460985347239390.0323328521288084
E2F6#187635.017155731697390.00791769806886330.0320187589488892
EGR1#195834.988179094810140.008056488137383440.0318861438752535
ELF1#199734.258097958807540.01295179875054610.0459733171229407
ELK4#2005316.2356816584680.0002336043955745990.00255042959119962
GABPB1#255337.067683836182170.002832212825417420.0153603092524158
IRF1#365937.63716375356390.002244692747297240.0127548131575069
MEF2A#4205318.74323090964410.0001518243905622470.00194724149894762
NFKB1#479035.488063424193840.006049381815655430.0268424772675038
PAX5#507936.669565531177830.003370290999677260.0172181099503641
POU2F2#545239.106124057742520.001324165192682130.00879176659621926
SP1#666735.69838137814090.005403962701712170.0245309888557446
SPI1#668838.204323508522730.001810593189410520.0108776197715627
SRF#6722313.79717826216780.0003806615025800190.00373786260511044
TAF7#6879311.43306940492390.0006690181981945830.00540258189138205
TCF7L2#6934310.77017656313730.0008003181298398380.00611399496469482
TFAP2C#7022310.80922860986020.0007916746575753130.00612684027880757
USF1#739136.361499277207960.00388404057290560.0189403424099401
YY1#752834.911170749853860.008441455341808260.0327726535981232
ZNF143#7702313.50087655222790.0004062804962997170.00387537937282365
ZNF263#1012738.221841637010680.001799043925565870.0108871450076587



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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