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{{Coexpression_clusters
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|full_id=C3919_Placental_Wilms_Adipocyte_Osteoblast_Mesenchymal_Alveolar_Urothelial
|id=C3919
|ontology_enrichment_celltype=CL:0002321!1.83e-19!248;CL:0000220!2.35e-19!246;CL:0000055!9.88e-19!180;CL:0000066!6.66e-12!254;CL:0000222!1.02e-10!119;CL:0000183!4.74e-10!59;CL:0000325!1.58e-09!39;CL:0000680!2.69e-09!57;CL:0000056!2.69e-09!57;CL:0000355!2.69e-09!57;CL:0000192!3.05e-09!42;CL:0000514!3.05e-09!42;CL:0000057!3.10e-09!75;CL:0000187!3.72e-09!54;CL:0000393!1.55e-08!60;CL:0000211!1.55e-08!60;CL:0000136!3.83e-08!15;CL:0000359!2.24e-07!32;CL:0000548!5.36e-07!679;CL:0000004!5.36e-07!679;CL:0000255!5.36e-07!679;CL:0002077!5.53e-07!33;CL:0000144!6.78e-07!625
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000475!1.10e-16!365;UBERON:0003102!1.33e-13!95;UBERON:0000468!2.61e-12!659;UBERON:0002100!2.66e-12!216;UBERON:0000486!1.03e-11!82;UBERON:0000914!4.47e-11!83;UBERON:0002329!4.47e-11!83;UBERON:0003077!4.47e-11!83;UBERON:0003059!4.47e-11!83;UBERON:0007282!4.47e-11!83;UBERON:0009618!4.47e-11!83;UBERON:0007285!4.47e-11!83;UBERON:0004872!5.55e-11!84;UBERON:0005256!2.49e-10!143;UBERON:0000483!4.73e-10!309;UBERON:0000119!7.70e-10!312;UBERON:0000467!3.40e-09!625;UBERON:0000480!3.44e-09!626;UBERON:0001637!3.62e-09!42;UBERON:0003509!3.62e-09!42;UBERON:0004572!3.62e-09!42;UBERON:0004290!3.72e-09!70;UBERON:0000481!1.04e-08!347;UBERON:0001981!1.59e-08!60;UBERON:0007500!1.59e-08!60;UBERON:0004537!1.59e-08!60;UBERON:0006965!1.59e-08!60;UBERON:0003104!1.74e-08!238;UBERON:0009142!1.74e-08!238;UBERON:0001134!1.82e-08!61;UBERON:0002036!1.82e-08!61;UBERON:0003082!1.82e-08!61;UBERON:0002385!3.36e-08!63;UBERON:0001015!3.36e-08!63;UBERON:0000383!3.36e-08!63;UBERON:0002049!3.71e-08!79;UBERON:0007798!3.71e-08!79;UBERON:0000055!3.73e-08!69;UBERON:0000477!1.10e-07!286;UBERON:0003914!1.54e-07!118;UBERON:0004573!2.23e-07!33;UBERON:0004571!2.23e-07!33;UBERON:0004111!2.54e-07!241;UBERON:0000064!5.50e-07!219;UBERON:0002199!5.85e-07!45;UBERON:0002416!5.85e-07!45;UBERON:0005631!6.96e-07!14;UBERON:0000158!6.96e-07!14
}}

Latest revision as of 12:35, 17 September 2013


Full id: C3919_Placental_Wilms_Adipocyte_Osteoblast_Mesenchymal_Alveolar_Urothelial



Phase1 CAGE Peaks

Hg19::chr1:201438237..201438248,-p6@PHLDA3
Hg19::chr1:201438253..201438278,-p2@PHLDA3
Hg19::chr1:201438282..201438365,-p1@PHLDA3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
surface structure5.61e-1599
organism subdivision2.08e-14264
multi-cellular organism5.28e-12656
multilaminar epithelium1.31e-1183
epithelium1.16e-10306
cell layer2.17e-10309
splanchnic layer of lateral plate mesoderm2.84e-1083
multi-tissue structure4.75e-10342
epithelial vesicle1.06e-0978
trunk2.22e-09199
anatomical system3.92e-09624
anatomical group4.20e-09625
dense mesenchyme tissue5.36e-0973
artery6.08e-0942
arterial blood vessel6.08e-0942
arterial system6.08e-0942
anatomical cluster6.19e-09373
somite9.81e-0971
presomitic mesoderm9.81e-0971
presumptive segmental plate9.81e-0971
dermomyotome9.81e-0971
trunk paraxial mesoderm9.81e-0971
paraxial mesoderm1.13e-0872
presumptive paraxial mesoderm1.13e-0872
organ component layer1.37e-0866
skeletal muscle tissue2.41e-0862
striated muscle tissue2.41e-0862
myotome2.41e-0862
muscle tissue4.91e-0864
musculature4.91e-0864
musculature of body4.91e-0864
epithelial tube open at both ends6.37e-0859
blood vessel6.37e-0859
blood vasculature6.37e-0859
vascular cord6.37e-0859
mesenchyme7.58e-08160
entire embryonic mesenchyme7.58e-08160
vessel1.52e-0768
vasculature2.18e-0778
vascular system2.18e-0778
systemic artery2.72e-0733
systemic arterial system2.72e-0733
trunk mesenchyme3.11e-07122
anatomical conduit3.94e-07240
head4.71e-0756
epithelial tube6.31e-07117
organ part6.58e-07218
renal system7.36e-0748
urinary system structure7.98e-0747
integument8.96e-0746
integumental system8.96e-0746
developing anatomical structure9.86e-07581
unilaminar epithelium9.98e-07148


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.15.30359
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.17.37849
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.12.1667
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.15.26983
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.62945
MA0138.21.04628
MA0002.20.476938
MA0137.22.70092
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.11.76247
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.12.48891
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.22.70224
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0279570864125395
E2F1#186934.907389214879320.008460985347239390.0325556072902897
EP300#203336.77394172622320.003216880500103790.0167556621889352
POU2F2#545239.106124057742520.001324165192682130.00882711996926846
SMARCB1#6598318.25271578115740.000164397760679890.00203141714714234
STAT3#6774310.51946499715420.0008589184530415310.00642859282766264
SUZ12#23512350.11578091106297.93834897779404e-060.000222450557792281
TCF7L2#6934310.77017656313730.0008003181298398380.00614184915587794



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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