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{{CL
{{CL
|id=CL:0000115
|name=endothelial cell
|namespace=cell
|def="An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://63.198.234.228/OpenFMA/Endothelial cell.html, MESH:D042783]
|xref=BTO:0001176;;FMA:66772
|is_a=CL:0000213;;CL:0002078
|synonym="Endotheliocyte" EXACT []
|comment=From FMA: \n9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classifiaction is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]
|alt_id=
|alt_id=
|disjoint_from=
|comment=From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://63.198.234.228/OpenFMA/Endothelial%20cell.html, https://sourceforge.net/tracker/?func
|subset=
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000115
|is_a=CL:0000213 ;;CL:0002078
|is_obsolete=
|located_in=
|located_in=
|name=endothelial cell
|namespace=FANTOM
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|subset=
|synonym="endotheliocyte" EXACT []
|union_of=
|xref=BTO:0001176;;FMA:66772
}}
}}

Latest revision as of 16:30, 12 September 2014

Name:endothelial cell
Namespace:FANTOM
Definition:"An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://63.198.234.228/OpenFMA/Endothelial%20cell.html, https://sourceforge.net/tracker/?func
Xrefs:
links:

BTO:0001176

FMA:66772
Synonyms: "endotheliocyte" EXACT []
Comments:From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000213(lining cell),CL:0002078(meso-epithelial cell)



Children


is a:CL:0002139 (endothelial cell of vascular tree),CL:0002188 (glomerular endothelial cell),CL:0002262 (endothelial cell of sinusoid),CL:0002367 (trabecular meshwork cell),FF:13595-146E4 (liver sinusoidal endothelial cells, sham operation, biol_rep1),FF:13596-146E5 (liver sinusoidal endothelial cells, sham operation, biol_rep2),FF:13597-146E6 (liver sinusoidal endothelial cells, sham operation, biol_rep3),FF:13598-146E7 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep1),FF:13599-146E8 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep2),FF:13600-146E9 (liver sinusoidal endothelial cells, partial hepatectomy, 02hr, biol_rep3),FF:13601-146F1 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep1),FF:13602-146F2 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep2),FF:13603-146F3 (liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep3),FF:13604-146F4 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep1),FF:13605-146F5 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep2),FF:13606-146F6 (liver sinusoidal endothelial cells, partial hepatectomy, 48hr, biol_rep3),FF:13607-146F7 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep1),FF:13608-146F8 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep2),FF:13609-146F9 (liver sinusoidal endothelial cells, partial hepatectomy, week01, biol_rep3)
derives from:FF:0000046 (human endothelial cell sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000115 (endothelial cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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