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Coexpression cluster:C129: Difference between revisions

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{{Coexpression_clusters
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Latest revision as of 10:38, 17 September 2013


Full id: C129_liver_Hepatocyte_colon_duodenum_temporal_testicular_small



Phase1 CAGE Peaks

Hg19::chr10:109856810..109856815,+p@chr10:109856810..109856815
+
Hg19::chr10:118342385..118342386,-p@chr10:118342385..118342386
-
Hg19::chr10:22046872..22046874,+p@chr10:22046872..22046874
+
Hg19::chr10:54531372..54531384,-p1@MBL2
Hg19::chr10:54531406..54531426,-p2@MBL2
Hg19::chr10:74653492..74653504,+p4@OIT3
Hg19::chr10:74653506..74653521,+p1@OIT3
Hg19::chr10:74653522..74653535,+p2@OIT3
Hg19::chr10:74653538..74653547,+p5@OIT3
Hg19::chr10:91403625..91403649,-p4@PANK1
Hg19::chr10:95351747..95351759,+p2@CU676593
Hg19::chr10:95351763..95351773,+p3@CU676593
Hg19::chr11:116700614..116700631,+p1@APOC3
Hg19::chr11:116701496..116701523,+p@chr11:116701496..116701523
+
Hg19::chr11:116701530..116701546,+p@chr11:116701530..116701546
+
Hg19::chr11:116703597..116703615,+p5@APOC3
Hg19::chr11:116703645..116703664,-p@chr11:116703645..116703664
-
Hg19::chr11:116706805..116706829,-p@chr11:116706805..116706829
-
Hg19::chr11:116706945..116706953,-p@chr11:116706945..116706953
-
Hg19::chr11:116706961..116706976,-p@chr11:116706961..116706976
-
Hg19::chr11:116706971..116706988,+p1@DQ656025
Hg19::chr11:116707091..116707117,-p@chr11:116707091..116707117
-
Hg19::chr11:116708330..116708347,-p1@APOA1
Hg19::chr11:2018018..2018021,-p2@MIR675
Hg19::chr11:2162543..2162562,-p61@IGF2
Hg19::chr11:63137251..63137267,+p1@SLC22A9
Hg19::chr12:104866693..104866694,+p@chr12:104866693..104866694
+
Hg19::chr12:4488872..4488879,-p1@FGF23
Hg19::chr12:56881993..56882009,-p5@GLS2
Hg19::chr12:6927703..6927726,+p@chr12:6927703..6927726
+
Hg19::chr12:6927729..6927757,+p@chr12:6927729..6927757
+
Hg19::chr12:96389702..96389722,-p1@HAL
Hg19::chr13:41363739..41363753,+p2@SLC25A15
Hg19::chr13:41455066..41455070,-p@chr13:41455066..41455070
-
Hg19::chr14:94844000..94844007,-p@chr14:94844000..94844007
-
Hg19::chr14:94844867..94844883,+p2@CU680153
Hg19::chr14:94844932..94844943,-p30@SERPINA1
Hg19::chr14:94845856..94845857,-p43@SERPINA1
Hg19::chr14:94849340..94849371,+p@chr14:94849340..94849371
+
Hg19::chr14:94849372..94849459,+p@chr14:94849372..94849459
+
Hg19::chr15:102028948..102028954,+p@chr15:102028948..102028954
+
Hg19::chr15:41548892..41548919,+p9@CHP
Hg19::chr15:51610687..51610695,-p4@CYP19A1
Hg19::chr15:58724170..58724183,+p3@LIPC
Hg19::chr15:58724184..58724197,+p2@LIPC
Hg19::chr15:81611633..81611637,-p@chr15:81611633..81611637
-
Hg19::chr16:51593720..51593721,-p@chr16:51593720..51593721
-
Hg19::chr16:56666563..56666580,+p2@MT1M
Hg19::chr16:56677565..56677579,+p2@MT1DP
Hg19::chr16:56685796..56685801,+p1@MT1B
Hg19::chr16:56691887..56691909,+p1@MT1F
Hg19::chr16:56700715..56700727,-p@chr16:56700715..56700727
-
Hg19::chr16:56700737..56700752,+p@chr16:56700737..56700752
+
Hg19::chr16:56701968..56701983,-p1@MT1G
Hg19::chr16:56703761..56703789,+p2@MT1H
Hg19::chr16:76566169..76566180,-p@chr16:76566169..76566180
-
Hg19::chr17:36860807..36860829,-p@chr17:36860807..36860829
-
Hg19::chr17:4692230..4692265,+p1@GLTPD2
Hg19::chr17:4692269..4692278,+p6@GLTPD2
Hg19::chr17:4692335..4692344,+p3@GLTPD2
Hg19::chr17:4692350..4692364,+p2@GLTPD2
Hg19::chr17:7018100..7018111,-p4@ASGR2
Hg19::chr17:7960200..7960204,+p1@uc002gjx.1
Hg19::chr18:56067319..56067325,-p@chr18:56067319..56067325
-
Hg19::chr19:11350278..11350302,+p1@C19orf80
Hg19::chr19:45451955..45451977,+p5@APOC2
Hg19::chr19:6712541..6712560,+p@chr19:6712541..6712560
+
Hg19::chr19:6718256..6718299,+p@chr19:6718256..6718299
+
Hg19::chr19:6719228..6719237,+p@chr19:6719228..6719237
+
Hg19::chr19:6719256..6719265,-p@chr19:6719256..6719265
-
Hg19::chr19:6719365..6719380,+p@chr19:6719365..6719380
+
Hg19::chr1:120311553..120311555,-p2@HMGCS2
Hg19::chr1:161192171..161192185,-p@chr1:161192171..161192185
-
Hg19::chr1:161192276..161192297,-p@chr1:161192276..161192297
-
Hg19::chr1:16410268..16410271,-p@chr1:16410268..16410271
-
Hg19::chr1:207262540..207262551,+p13@C4BPB
Hg19::chr1:207262571..207262574,+p19@C4BPB
Hg19::chr1:230839071..230839081,-p@chr1:230839071..230839081
-
Hg19::chr1:230840033..230840046,+p@chr1:230840033..230840046
+
Hg19::chr1:230841888..230841906,-p@chr1:230841888..230841906
-
Hg19::chr1:230841927..230841948,-p@chr1:230841927..230841948
-
Hg19::chr1:230845912..230845927,-p@chr1:230845912..230845927
-
Hg19::chr1:230846000..230846009,-p@chr1:230846000..230846009
-
Hg19::chr1:230846364..230846384,+p1@M26228
Hg19::chr1:230846397..230846417,-p2@AGT
Hg19::chr1:230849858..230849875,-p1@AGT
Hg19::chr1:48121226..48121227,+p@chr1:48121226..48121227
+
Hg19::chr1:80339337..80339339,+p@chr1:80339337..80339339
+
Hg19::chr20:36956110..36956113,-p@chr20:36956110..36956113
-
Hg19::chr20:4163964..4164001,+p@chr20:4163964..4164001
+
Hg19::chr22:26921050..26921055,+p@chr22:26921050..26921055
+
Hg19::chr22:30953574..30953584,-p13@GAL3ST1
Hg19::chr22:30953587..30953595,-p15@GAL3ST1
Hg19::chr22:37505474..37505478,-p3@TMPRSS6
Hg19::chr2:164347637..164347639,-p@chr2:164347637..164347639
-
Hg19::chr2:211542816..211542823,+p@chr2:211542816..211542823
+
Hg19::chr2:21234737..21234744,-p116@APOB
Hg19::chr2:21256354..21256359,-p@chr2:21256354..21256359
-
Hg19::chr2:21257701..21257711,+p@chr2:21257701..21257711
+
Hg19::chr2:21260016..21260042,+p@chr2:21260016..21260042
+
Hg19::chr2:21265277..21265305,+p@chr2:21265277..21265305
+
Hg19::chr2:234959355..234959371,+p2@SPP2
Hg19::chr2:234959376..234959402,+p1@SPP2
Hg19::chr2:241808165..241808178,+p2@AGXT
Hg19::chr2:97216094..97216105,+p@chr2:97216094..97216105
+
Hg19::chr3:133473408..133473419,+p10@TF
Hg19::chr3:142682480..142682497,-p3@PAQR9
Hg19::chr3:186330841..186330863,+p1@AHSG
Hg19::chr3:186333534..186333545,+p@chr3:186333534..186333545
+
Hg19::chr3:186334990..186335031,+p@chr3:186334990..186335031
+
Hg19::chr3:186335044..186335062,+p@chr3:186335044..186335062
+
Hg19::chr3:186336312..186336319,+p@chr3:186336312..186336319
+
Hg19::chr3:186338441..186338458,+p@chr3:186338441..186338458
+
Hg19::chr3:186338947..186338958,+p@chr3:186338947..186338958
+
Hg19::chr3:186338971..186338979,+p@chr3:186338971..186338979
+
Hg19::chr3:32280051..32280087,-p1@BC035064
Hg19::chr3:52821910..52821922,+p6@ITIH1
Hg19::chr4:74274493..74274496,+p45@ALB
Hg19::chr4:74283355..74283358,-p@chr4:74283355..74283358
-
Hg19::chr4:74319533..74319551,+p@chr4:74319533..74319551
+
Hg19::chr5:126215130..126215131,+p@chr5:126215130..126215131
+
Hg19::chr5:132209353..132209366,+p1@LEAP2
Hg19::chr6:43027721..43027733,+p5@KLC4
Hg19::chr6:5085572..5085576,+p2@PPP1R3G
Hg19::chr7:100238869..100238883,-p@chr7:100238869..100238883
-
Hg19::chr7:45928132..45928134,+p11@IGFBP1
Hg19::chr7:99332815..99332820,-p1@CYP3A7
p2@CYP3A5
Hg19::chr8:28244374..28244382,-p26@ZNF395
Hg19::chr9:104145795..104145806,-p4@BAAT
Hg19::chr9:107666048..107666061,-p7@ABCA1
Hg19::chr9:116823375..116823380,-p7@AMBP
Hg19::chr9:4839762..4839779,+p6@RCL1
Hg19::chr9:4839818..4839828,+p8@RCL1
Hg19::chrX:105251903..105251912,-p@chrX:105251903..105251912
-
Hg19::chrX:108976521..108976545,-p3@ACSL4
Hg19::chrX:132670143..132670152,-p@chrX:132670143..132670152
-
Hg19::chrX:132670211..132670224,-p@chrX:132670211..132670224
-
Hg19::chrX:153769409..153769421,+p15@IKBKG
Hg19::chrX:49832232..49832267,+p5@CLCN5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
0.001442056292335430.0480432438446489232Alanine, aspartate and glutamate metabolism (KEGG):00250
0.0007430068925370710.0276660801750568223Nitrogen metabolism (KEGG):00910
2.33960129959674e-050.00148096762264474101138Metabolic pathways (KEGG):01100
7.42008564011457e-060.000587114276274066471PPAR signaling pathway (KEGG):03320
0.0003506682377116250.0158552138908185378Peroxisome (KEGG):04146
0.000244197721821170.011890550608677369Complement and coagulation cascades (KEGG):04610
7.27844308158643e-050.0041884131551311346Fat digestion and absorption (KEGG):04975
0.0008096464670809590.0284725674256804224Vitamin digestion and absorption (KEGG):04977
3.58995175067169e-107.57479819391727e-08651Mineral absorption (KEGG):04978
4.03691869703112e-060.00041561279877618461Selenium Pathway (Wikipathways):WP15
2.11867675407872e-060.000268224477066366452Vitamin B12 Metabolism (Wikipathways):WP1533
4.5960341096892e-060.00041561279877618463Folate Metabolism (Wikipathways):WP176
9.7484418554213e-123.08538184724084e-09629Statin Pathway (Wikipathways):WP430
0.0001585315700854290.008362540322006376466Hemostasis (Reactome):REACT_604
7.95131208698848e-145.03318055106371e-1112289Metabolism of lipids and lipoproteins (Reactome):REACT_22258
0.0003803155508789040.01604931624708974195Metabolism of amino acids and derivatives (Reactome):REACT_13
8.71044580910769e-060.0006126346885739075159EGFR1 up reg. targets (Netpath):NetPath_4
1.85032686852687e-092.92814226944378e-07530{SDC1,30} (Static Module):NA
0.0004831982154292750.0191165293979207387{SP1,88} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005615extracellular space1.48086432370248e-10
GO:0044421extracellular region part6.57448167385691e-08
GO:0046870cadmium ion binding1.07053834821666e-07
GO:0032501multicellular organismal process1.07098905689507e-07
GO:0006629lipid metabolic process5.39357397914303e-07
GO:0005319lipid transporter activity5.39357397914303e-07
GO:0044255cellular lipid metabolic process5.93014759482007e-07
GO:0015918sterol transport8.58942756579416e-07
GO:0030301cholesterol transport8.58942756579416e-07
GO:0006869lipid transport2.52091414113614e-06
GO:0065008regulation of biological quality3.440761370017e-06
GO:0002526acute inflammatory response5.52163142747491e-06
GO:0051239regulation of multicellular organismal process6.07008552608326e-06
GO:0042627chylomicron8.0558945854026e-06
GO:0006810transport2.80207081469866e-05
GO:0005507copper ion binding2.88256114622693e-05
GO:0008202steroid metabolic process2.88256114622693e-05
GO:0051234establishment of localization4.20686384807624e-05
GO:0004866endopeptidase inhibitor activity5.25691872096465e-05
GO:0030414protease inhibitor activity6.83242618215475e-05
GO:0006641triacylglycerol metabolic process7.69547300248815e-05
GO:0009605response to external stimulus7.69547300248815e-05
GO:0030139endocytic vesicle0.000133068156671684
GO:0008203cholesterol metabolic process0.00013524283622399
GO:0006638neutral lipid metabolic process0.00013524283622399
GO:0006639acylglycerol metabolic process0.00013524283622399
GO:0046486glycerolipid metabolic process0.000148697483236104
GO:0006662glycerol ether metabolic process0.000162087116637339
GO:0051179localization0.000162087116637339
GO:0016125sterol metabolic process0.000238208181255638
GO:0050776regulation of immune response0.000271650017635703
GO:0019752carboxylic acid metabolic process0.000271650017635703
GO:0002682regulation of immune system process0.000271650017635703
GO:0006082organic acid metabolic process0.000271650017635703
GO:0006953acute-phase response0.000278980367605687
GO:0004857enzyme inhibitor activity0.000396218796457818
GO:0009611response to wounding0.000507707147740188
GO:0009308amine metabolic process0.000507707147740188
GO:0000267cell fraction0.000570676404315978
GO:0033344cholesterol efflux0.00058383456311079
GO:0006807nitrogen compound metabolic process0.000707087960943878
GO:0032787monocarboxylic acid metabolic process0.000889754724505307
GO:0006954inflammatory response0.000928048924478177
GO:0005737cytoplasm0.00102394198824895
GO:0044444cytoplasmic part0.0011977275275191
GO:0019825oxygen binding0.00120271997368007
GO:0008015blood circulation0.00120271997368007
GO:0003013circulatory system process0.00120271997368007
GO:0005792microsome0.00123633628213574
GO:0004867serine-type endopeptidase inhibitor activity0.00139492551803167
GO:0042598vesicular fraction0.00139934583542896
GO:0030500regulation of bone mineralization0.00163961905541608
GO:0002253activation of immune response0.00204588633702832
GO:0006631fatty acid metabolic process0.00208076718368457
GO:0006952defense response0.00208076718368457
GO:0001501skeletal development0.00288535090839581
GO:0006950response to stress0.00318817735025831
GO:0050778positive regulation of immune response0.00318817735025831
GO:0002684positive regulation of immune system process0.00324434981061394
GO:0030278regulation of ossification0.00428912329622161
GO:0046849bone remodeling0.00428912329622161
GO:0005624membrane fraction0.00428912329622161
GO:0030282bone mineralization0.00452216305197419
GO:0007596blood coagulation0.00452216305197419
GO:0005777peroxisome0.00452216305197419
GO:0042579microbody0.00452216305197419
GO:0050817coagulation0.00472121610869589
GO:0051240positive regulation of multicellular organismal process0.00491967566122464
GO:0048771tissue remodeling0.00491967566122464
GO:0007599hemostasis0.00491967566122464
GO:0006520amino acid metabolic process0.00543490017068413
GO:0046850regulation of bone remodeling0.00587610010638861
GO:0022892substrate-specific transporter activity0.00620908591586319
GO:0051241negative regulation of multicellular organismal process0.00620908591586319
GO:0050381unspecific monooxygenase activity0.00654385201519291
GO:0042552myelination0.00654385201519291
GO:0050878regulation of body fluid levels0.00740307464757534
GO:0006958complement activation, classical pathway0.00740307464757534
GO:0042060wound healing0.00829211968876683
GO:0002455humoral immune response mediated by circulating immunoglobulin0.00829211968876683
GO:0006519amino acid and derivative metabolic process0.00898918200096567
GO:0008366axon ensheathment0.00898918200096567
GO:0008286insulin receptor signaling pathway0.00898918200096567
GO:0007272ensheathment of neurons0.00898918200096567
GO:0016042lipid catabolic process0.00943506417049335
GO:0051704multi-organism process0.00943506417049335
GO:0008610lipid biosynthetic process0.00943506417049335
GO:0008289lipid binding0.00943506417049335
GO:0016247channel regulator activity0.00943506417049335
GO:0048731system development0.00943506417049335
GO:0006956complement activation0.00943506417049335
GO:0002541activation of plasma proteins during acute inflammatory response0.00943506417049335
GO:0048856anatomical structure development0.00943506417049335
GO:0001508regulation of action potential0.00943506417049335
GO:0002018renin-angiotensin regulation of aldosterone production0.00943506417049335
GO:0030568plasmin inhibitor activity0.00943506417049335
GO:0015682ferric iron transport0.00943506417049335
GO:0031643positive regulation of myelination0.00943506417049335
GO:0048143astrocyte activation0.00943506417049335
GO:0031701angiotensin receptor binding0.00943506417049335
GO:0002019angiotensin mediated regulation of renal output0.00943506417049335
GO:0004760serine-pyruvate transaminase activity0.00943506417049335
GO:0031703type 2 angiotensin receptor binding0.00943506417049335
GO:0043395heparan sulfate proteoglycan binding0.00943506417049335
GO:0019375galactolipid biosynthetic process0.00943506417049335
GO:0004397histidine ammonia-lyase activity0.00943506417049335
GO:0046724oxalic acid secretion0.00943506417049335
GO:0060155platelet dense granule organization and biogenesis0.00943506417049335
GO:0043394proteoglycan binding0.00943506417049335
GO:0042866pyruvate biosynthetic process0.00943506417049335
GO:0006682galactosylceramide biosynthetic process0.00943506417049335
GO:0046622positive regulation of organ growth0.00943506417049335
GO:0019265glycine biosynthetic process, by transamination of glyoxylate0.00943506417049335
GO:0051657maintenance of organelle localization0.00943506417049335
GO:0006642triacylglycerol mobilization0.00943506417049335
GO:0045723positive regulation of fatty acid biosynthetic process0.00943506417049335
GO:0046904calcium oxalate binding0.00943506417049335
GO:0042756drinking behavior0.00943506417049335
GO:0043691reverse cholesterol transport0.00943506417049335
GO:0015091ferric iron transmembrane transporter activity0.00943506417049335
GO:0001999renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure0.00943506417049335
GO:0051659maintenance of mitochondrion localization0.00943506417049335
GO:0047963glycine N-choloyltransferase activity0.00943506417049335
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure0.00943506417049335
GO:0031702type 1 angiotensin receptor binding0.00943506417049335
GO:0006544glycine metabolic process0.0108073824515304
GO:0030198extracellular matrix organization and biogenesis0.0121622031698151
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0.0121622031698151
GO:0004091carboxylesterase activity0.0141346188940538
GO:0016064immunoglobulin mediated immune response0.0143731936705695
GO:0019724B cell mediated immunity0.0143731936705695
GO:0006487protein amino acid N-linked glycosylation0.0143731936705695
GO:0010324membrane invagination0.0143731936705695
GO:0006897endocytosis0.0143731936705695
GO:0009069serine family amino acid metabolic process0.0143731936705695
GO:0040008regulation of growth0.0143731936705695
GO:0000066mitochondrial ornithine transport0.0143731936705695
GO:0033700phospholipid efflux0.0143731936705695
GO:0014821phasic smooth muscle contraction0.0143731936705695
GO:0003072renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence0.0143731936705695
GO:0004421hydroxymethylglutaryl-CoA synthase activity0.0143731936705695
GO:0033363secretory granule organization and biogenesis0.0143731936705695
GO:0002034renin-angiotensin regulation of blood vessel size0.0143731936705695
GO:0000064L-ornithine transmembrane transporter activity0.0143731936705695
GO:0055091phospholipid homeostasis0.0143731936705695
GO:0002016renin-angiotensin regulation of blood volume0.0143731936705695
GO:0046337phosphatidylethanolamine metabolic process0.0143731936705695
GO:0002035brain renin-angiotensin system0.0143731936705695
GO:0001867complement activation, lectin pathway0.0143731936705695
GO:0008065establishment of blood-nerve barrier0.0143731936705695
GO:0030810positive regulation of nucleotide biosynthetic process0.0143731936705695
GO:0043072negative regulation of non-apoptotic programmed cell death0.0143731936705695
GO:0030816positive regulation of cAMP metabolic process0.0143731936705695
GO:0045981positive regulation of nucleotide metabolic process0.0143731936705695
GO:0030432peristalsis0.0143731936705695
GO:0030801positive regulation of cyclic nucleotide metabolic process0.0143731936705695
GO:0001543ovarian follicle rupture0.0143731936705695
GO:0030349syntaxin-13 binding0.0143731936705695
GO:0042304regulation of fatty acid biosynthetic process0.0143731936705695
GO:0030804positive regulation of cyclic nucleotide biosynthetic process0.0143731936705695
GO:0019862IgA binding0.0143731936705695
GO:0030819positive regulation of cAMP biosynthetic process0.0143731936705695
GO:0019855calcium channel inhibitor activity0.0143731936705695
GO:0015822ornithine transport0.0143731936705695
GO:0048518positive regulation of biological process0.015645726955851
GO:0031667response to nutrient levels0.0158459236380062
GO:0006066alcohol metabolic process0.016009523212049
GO:0010033response to organic substance0.0166989084016075
GO:0009991response to extracellular stimulus0.0172364109538812
GO:0005625soluble fraction0.0172364109538812
GO:0030246carbohydrate binding0.0172364109538812
GO:0052185modification of structure of other organism during symbiotic interaction0.0172364109538812
GO:0030304trypsin inhibitor activity0.0172364109538812
GO:0051883killing of cells in other organism during symbiotic interaction0.0172364109538812
GO:0046476glycosylceramide biosynthetic process0.0172364109538812
GO:0046329negative regulation of JNK cascade0.0172364109538812
GO:0052331hemolysis by organism of red blood cells in other organism during symbiotic interaction0.0172364109538812
GO:0001991regulation of systemic arterial blood pressure by circulatory renin-angiotensin0.0172364109538812
GO:0003071renal regulation of systemic arterial blood pressure0.0172364109538812
GO:0046149pigment catabolic process0.0172364109538812
GO:0019836hemolysis by symbiont of host red blood cells0.0172364109538812
GO:0051801cytolysis of cells in other organism during symbiotic interaction0.0172364109538812
GO:0004873asialoglycoprotein receptor activity0.0172364109538812
GO:0001907killing by symbiont of host cells0.0172364109538812
GO:0031640killing of cells of another organism0.0172364109538812
GO:0001897cytolysis by symbiont of host cells0.0172364109538812
GO:0016244non-apoptotic programmed cell death0.0172364109538812
GO:0001885endothelial cell development0.0172364109538812
GO:0046461neutral lipid catabolic process0.0172364109538812
GO:0046487glyoxylate metabolic process0.0172364109538812
GO:0051818disruption of cells of other organism during symbiotic interaction0.0172364109538812
GO:0008453alanine-glyoxylate transaminase activity0.0172364109538812
GO:0044004disruption by symbiont of host cells0.0172364109538812
GO:0051817modification of morphology or physiology of other organism during symbiotic interaction0.0172364109538812
GO:0051715cytolysis of cells of another organism0.0172364109538812
GO:0052332modification by organism of cell membrane in other organism during symbiotic interaction0.0172364109538812
GO:0043070regulation of non-apoptotic programmed cell death0.0172364109538812
GO:0046889positive regulation of lipid biosynthetic process0.0172364109538812
GO:0052111modification by symbiont of host structure0.0172364109538812
GO:0042167heme catabolic process0.0172364109538812
GO:0045335phagocytic vesicle0.0172364109538812
GO:0052025modification by symbiont of host cell membrane0.0172364109538812
GO:0052043modification by symbiont of host cellular component0.0172364109538812
GO:0044003modification by symbiont of host morphology or physiology0.0172364109538812
GO:0052188modification of cellular component in other organism during symbiotic interaction0.0172364109538812
GO:0009891positive regulation of biosynthetic process0.0172731238559978
GO:0048513organ development0.0177257174712722
GO:0032502developmental process0.017988280443683
GO:0002449lymphocyte mediated immunity0.017988280443683
GO:0003008system process0.018221097311605
GO:0006959humoral immune response0.0192946558716782
GO:0008201heparin binding0.0194307744560461
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0194307744560461
GO:0009725response to hormone stimulus0.0194307744560461
GO:0002250adaptive immune response0.0194307744560461
GO:0002443leukocyte mediated immunity0.0198656814051785
GO:0009058biosynthetic process0.0198656814051785
GO:0006907pinocytosis0.0198656814051785
GO:0055062phosphate ion homeostasis0.0198656814051785
GO:0031641regulation of myelination0.0198656814051785
GO:0032366intracellular sterol transport0.0198656814051785
GO:0006545glycine biosynthetic process0.0198656814051785
GO:0001733galactosylceramide sulfotransferase activity0.0198656814051785
GO:0015643toxin binding0.0198656814051785
GO:0046717acid secretion0.0198656814051785
GO:0046620regulation of organ growth0.0198656814051785
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin0.0198656814051785
GO:0001542ovulation from ovarian follicle0.0198656814051785
GO:0030502negative regulation of bone mineralization0.0198656814051785
GO:0014002astrocyte development0.0198656814051785
GO:0032365intracellular lipid transport0.0198656814051785
GO:0050694galactose 3-O-sulfotransferase activity0.0198656814051785
GO:0032367intracellular cholesterol transport0.0198656814051785
GO:0030643cellular phosphate ion homeostasis0.0198656814051785
GO:0016841ammonia-lyase activity0.0198656814051785
GO:0046627negative regulation of insulin receptor signaling pathway0.0198656814051785
GO:0046473phosphatidic acid metabolic process0.0198656814051785
GO:0007565female pregnancy0.0198695617356605
GO:0016053organic acid biosynthetic process0.0206597843310698
GO:0046394carboxylic acid biosynthetic process0.0206597843310698
GO:0042157lipoprotein metabolic process0.0209707789955566
GO:0043062extracellular structure organization and biogenesis0.0209707789955566
GO:0065007biological regulation0.0224329805746186
GO:0031214biomineral formation0.0226204327802265
GO:0001503ossification0.0226204327802265
GO:0006694steroid biosynthetic process0.0226204327802265
GO:0016044membrane organization and biogenesis0.0226204327802265
GO:0051646mitochondrion localization0.0226204327802265
GO:0030319cellular di-, tri-valent inorganic anion homeostasis0.0226204327802265
GO:0055061di-, tri-valent inorganic anion homeostasis0.0226204327802265
GO:0046626regulation of insulin receptor signaling pathway0.0226204327802265
GO:0008035high-density lipoprotein binding0.0226204327802265
GO:0030728ovulation0.0226204327802265
GO:0006787porphyrin catabolic process0.0226204327802265
GO:0033015tetrapyrrole catabolic process0.0226204327802265
GO:0030817regulation of cAMP biosynthetic process0.0226204327802265
GO:0019374galactolipid metabolic process0.0226204327802265
GO:0004594pantothenate kinase activity0.0226204327802265
GO:0035265organ growth0.0226204327802265
GO:0006681galactosylceramide metabolic process0.0226204327802265
GO:0020037heme binding0.0239199444095962
GO:0046906tetrapyrrole binding0.0239199444095962
GO:0048878chemical homeostasis0.0256046491335867
GO:0004359glutaminase activity0.0256046491335867
GO:0045923positive regulation of fatty acid metabolic process0.0256046491335867
GO:0001948glycoprotein binding0.0256046491335867
GO:0030802regulation of cyclic nucleotide biosynthetic process0.0256046491335867
GO:0030808regulation of nucleotide biosynthetic process0.0256046491335867
GO:0055081anion homeostasis0.0256046491335867
GO:0005381iron ion transmembrane transporter activity0.0256046491335867
GO:0004465lipoprotein lipase activity0.0256046491335867
GO:0008385IkappaB kinase complex0.0256046491335867
GO:0006349genetic imprinting0.0256046491335867
GO:0030814regulation of cAMP metabolic process0.0256046491335867
GO:0030002cellular anion homeostasis0.0256046491335867
GO:0044429mitochondrial part0.0256046491335867
GO:0042221response to chemical stimulus0.0258120680052261
GO:0009968negative regulation of signal transduction0.0275711386207889
GO:0016192vesicle-mediated transport0.0282511015481634
GO:0046470phosphatidylcholine metabolic process0.0290563391892623
GO:0003084positive regulation of systemic arterial blood pressure0.0290563391892623
GO:0015937coenzyme A biosynthetic process0.0290563391892623
GO:0030799regulation of cyclic nucleotide metabolic process0.0290563391892623
GO:0005539glycosaminoglycan binding0.0299483410283475
GO:0002252immune effector process0.0299483410283475
GO:0031967organelle envelope0.0300571043717113
GO:0009056catabolic process0.0300571043717113
GO:0031975envelope0.0302399763811864
GO:0045087innate immune response0.0303929885195778
GO:0009409response to cold0.0303929885195778
GO:0019627urea metabolic process0.0303929885195778
GO:0009267cellular response to starvation0.0303929885195778
GO:0048708astrocyte differentiation0.0303929885195778
GO:0006677glycosylceramide metabolic process0.0303929885195778
GO:0051145smooth muscle cell differentiation0.0303929885195778
GO:0000050urea cycle0.0303929885195778
GO:0046513ceramide biosynthetic process0.0303929885195778
GO:0019217regulation of fatty acid metabolic process0.0303929885195778
GO:0050886endocrine process0.0303929885195778
GO:0001990regulation of systemic arterial blood pressure by hormone0.0303929885195778
GO:0018445prothoracicotrophic hormone activity0.0303929885195778
GO:0030279negative regulation of ossification0.0303929885195778
GO:0001976regulation of systemic arterial blood pressure by neurological process0.0303929885195778
GO:0006658phosphatidylserine metabolic process0.0303929885195778
GO:0046890regulation of lipid biosynthetic process0.0303929885195778
GO:0043410positive regulation of MAPKKK cascade0.0303929885195778
GO:0043603amide metabolic process0.0303929885195778
GO:0031646positive regulation of neurological process0.0303929885195778
GO:0016290palmitoyl-CoA hydrolase activity0.0303929885195778
GO:0030247polysaccharide binding0.0304763743155302
GO:0016043cellular component organization and biogenesis0.0307704570726559
GO:0030170pyridoxal phosphate binding0.0307704570726559
GO:0005739mitochondrion0.0307704570726559
GO:0007275multicellular organismal development0.031239155641175
GO:0016023cytoplasmic membrane-bound vesicle0.0320626442860655
GO:0031988membrane-bound vesicle0.0324873069080913
GO:0042730fibrinolysis0.0324873069080913
GO:0003014renal system process0.0324873069080913
GO:0046520sphingoid biosynthetic process0.0324873069080913
GO:0050766positive regulation of phagocytosis0.0324873069080913
GO:0016880acid-ammonia (or amide) ligase activity0.0324873069080913
GO:0003963RNA-3'-phosphate cyclase activity0.0324873069080913
GO:0016211ammonia ligase activity0.0324873069080913
GO:0050777negative regulation of immune response0.0324873069080913
GO:0015012heparan sulfate proteoglycan biosynthetic process0.0324873069080913
GO:0012505endomembrane system0.0329919746541193
GO:0005102receptor binding0.0340520350007429
GO:0001871pattern binding0.0342283290911175
GO:0002683negative regulation of immune system process0.0343805568152402
GO:0031669cellular response to nutrient levels0.0343805568152402
GO:0050764regulation of phagocytosis0.0343805568152402
GO:0006140regulation of nucleotide metabolic process0.0343805568152402
GO:0045777positive regulation of blood pressure0.0343805568152402
GO:0045834positive regulation of lipid metabolic process0.0343805568152402
GO:0001658ureteric bud branching0.0343805568152402
GO:0008200ion channel inhibitor activity0.0343805568152402
GO:0004467long-chain-fatty-acid-CoA ligase activity0.0343805568152402
GO:0050702interleukin-1 beta secretion0.0343805568152402
GO:0015645fatty-acid ligase activity0.0343805568152402
GO:0030212hyaluronan metabolic process0.0343805568152402
GO:0016248channel inhibitor activity0.0343805568152402
GO:0007243protein kinase cascade0.0365088409130551
GO:0005159insulin-like growth factor receptor binding0.0365088409130551
GO:0043524negative regulation of neuron apoptosis0.0365088409130551
GO:0005246calcium channel regulator activity0.0365088409130551
GO:0009070serine family amino acid biosynthetic process0.0365088409130551
GO:0051591response to cAMP0.0365088409130551
GO:0046851negative regulation of bone remodeling0.0365088409130551
GO:0017127cholesterol transporter activity0.0365088409130551
GO:0014070response to organic cyclic substance0.0365088409130551
GO:0015936coenzyme A metabolic process0.0365088409130551
GO:0045446endothelial cell differentiation0.0365088409130551
GO:0050701interleukin-1 secretion0.0365088409130551
GO:0046903secretion0.0373811331880424
GO:0031090organelle membrane0.0384406423736267
GO:0016298lipase activity0.0384406423736267
GO:0051384response to glucocorticoid stimulus0.0388119603610069
GO:0040018positive regulation of multicellular organism growth0.0388119603610069
GO:0003044regulation of systemic arterial blood pressure mediated by a chemical signal0.0388119603610069
GO:0030195negative regulation of blood coagulation0.0388119603610069
GO:0005537mannose binding0.0388119603610069
GO:0030201heparan sulfate proteoglycan metabolic process0.0388119603610069
GO:0006548histidine catabolic process0.0412214045994903
GO:0021782glial cell development0.0412214045994903
GO:0031960response to corticosteroid stimulus0.0412214045994903
GO:0015248sterol transporter activity0.0412214045994903
GO:0009077histidine family amino acid catabolic process0.0412214045994903
GO:0042594response to starvation0.0412214045994903
GO:0030193regulation of blood coagulation0.0412214045994903
GO:0000165MAPKKK cascade0.0415561401497214
GO:0031966mitochondrial membrane0.0418541795420645
GO:0016886ligase activity, forming phosphoric ester bonds0.0436531434065266
GO:0048659smooth muscle cell proliferation0.0436531434065266
GO:0050821protein stabilization0.0436531434065266
GO:0031668cellular response to extracellular stimulus0.0436531434065266
GO:0042803protein homodimerization activity0.0450782411214411
GO:0031410cytoplasmic vesicle0.0457640289410509
GO:0008206bile acid metabolic process0.0457640289410509
GO:0006625protein targeting to peroxisome0.0457640289410509
GO:0009247glycolipid biosynthetic process0.0457640289410509
GO:0043408regulation of MAPKKK cascade0.0457640289410509
GO:0016840carbon-nitrogen lyase activity0.0457640289410509
GO:0050819negative regulation of coagulation0.0457640289410509
GO:0001558regulation of cell growth0.0462517194614314
GO:0005740mitochondrial envelope0.0465941973071202
GO:0031982vesicle0.0465941973071202
GO:0001568blood vessel development0.0468358300759216
GO:0048519negative regulation of biological process0.0470624262182418
GO:0001944vasculature development0.0470624262182418
GO:0050818regulation of coagulation0.0470624262182418
GO:0019865immunoglobulin binding0.0470624262182418
GO:0003073regulation of systemic arterial blood pressure0.0470624262182418
GO:0042310vasoconstriction0.0470624262182418
GO:0043574peroxisomal transport0.0470624262182418
GO:0016050vesicle organization and biogenesis0.0470624262182418
GO:0033554cellular response to stress0.0470624262182418
GO:0004806triacylglycerol lipase activity0.0491049780645851
GO:0001906cell killing0.0491049780645851
GO:0050852T cell receptor signaling pathway0.0491049780645851
GO:0055088lipid homeostasis0.0491049780645851
GO:0048029monosaccharide binding0.0491049780645851
GO:0046912transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer0.0491049780645851
GO:0015485cholesterol binding0.0491049780645851



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
metabolising cell2.24e-4212
endopolyploid cell2.24e-4212
parenchymal cell2.24e-4212
polyploid cell2.24e-4212
hepatocyte2.24e-4212
endodermal cell5.72e-1558
Uber Anatomy
Ontology termp-valuen
liver2.27e-4719
digestive gland2.27e-4719
liver bud2.27e-4719
hepatic diverticulum7.55e-4122
liver primordium7.55e-4122
digestive tract diverticulum4.73e-3923
epithelial sac6.89e-3625
epithelium of foregut-midgut junction6.89e-3625
anatomical boundary6.89e-3625
hepatobiliary system6.89e-3625
foregut-midgut junction6.89e-3625
septum transversum6.89e-3625
sac1.73e-3426
exocrine gland7.68e-2931
exocrine system7.68e-2931
endocrine gland1.76e-2535
gut epithelium2.39e-2554
abdomen element1.57e-2054
abdominal segment element1.57e-2054
endocrine system1.10e-1945
gland9.69e-1959
abdominal segment of trunk2.14e-1860
abdomen2.14e-1860
endo-epithelium2.28e-1682
subdivision of digestive tract2.58e-13118
foregut2.02e-1287
digestive system1.24e-10145
digestive tract1.24e-10145
primitive gut1.24e-10145
trunk region element1.42e-10101
endoderm-derived structure1.59e-09160
endoderm1.59e-09160
presumptive endoderm1.59e-09160
subdivision of trunk1.92e-09112
immaterial anatomical entity5.33e-09117
trunk mesenchyme1.34e-08122
unilaminar epithelium1.36e-08148
epithelial tube4.01e-07117


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00191735
MA0004.10.472922
MA0006.10.00313781
MA0007.11.22866
MA0009.10.049269
MA0014.10.00487621
MA0017.15.12465
MA0019.10.134243
MA0024.10.0246296
MA0025.11.09463
MA0027.11.30259
MA0028.10.0123605
MA0029.10.834777
MA0030.10.799083
MA0031.10.911702
MA0038.10.305883
MA0040.10.291184
MA0041.10.0344866
MA0042.10.287354
MA0043.10.185158
MA0046.18.48641
MA0048.10.408702
MA0050.10.00725441
MA0051.10.00145249
MA0052.10.545567
MA0055.10.107375
MA0056.10
MA0057.10.136517
MA0058.10.276679
MA0059.11.09673
MA0060.10.0244967
MA0061.10.0759327
MA0063.10
MA0066.12.26971
MA0067.10.190212
MA0068.11.89255
MA0069.10.172185
MA0070.10.371416
MA0071.11.91212
MA0072.10.652114
MA0073.17.294e-06
MA0074.10.0343414
MA0076.10.00681866
MA0077.10.633425
MA0078.10.55842
MA0081.10.111671
MA0083.10.191527
MA0084.10.841536
MA0087.10.36052
MA0088.10.00976753
MA0089.10
MA0090.10.379172
MA0091.10.212704
MA0092.10.496173
MA0093.10.815816
MA0095.10
MA0098.10
MA0100.10.740053
MA0101.10.0223386
MA0103.10.436911
MA0105.10.0295282
MA0106.11.83728
MA0107.10.0303281
MA0108.21.2535
MA0109.10
MA0111.11.49262
MA0113.10.14853
MA0114.18.26834
MA0115.10.885511
MA0116.10.760991
MA0117.10.0607969
MA0119.10.0234078
MA0122.10.895957
MA0124.10.795162
MA0125.10.0892736
MA0130.10
MA0131.10.0359933
MA0132.10
MA0133.10
MA0135.10.212475
MA0136.10.322087
MA0139.10.454802
MA0140.11.2451
MA0141.14.76283
MA0142.10.153597
MA0143.10.451115
MA0144.11.20708
MA0145.10.13731
MA0146.10.0337363
MA0147.10.214895
MA0148.11.01219
MA0149.10.000664761
MA0062.28.69994e-05
MA0035.20.966417
MA0039.20.00512062
MA0138.21.12019
MA0002.21.1772
MA0137.20.972322
MA0104.20.144224
MA0047.20.37548
MA0112.20.922297
MA0065.25.52651
MA0150.10.357939
MA0151.10
MA0152.10.546979
MA0153.14.8083
MA0154.10.282403
MA0155.10.695522
MA0156.10.0617214
MA0157.10.455691
MA0158.10
MA0159.11.57066
MA0160.11.10754
MA0161.10
MA0162.14.67743e-05
MA0163.10.0101998
MA0164.10.163539
MA0080.20.122656
MA0018.20.0566924
MA0099.20.23303
MA0079.23.27777e-08
MA0102.20.340338
MA0258.11.91517
MA0259.10.245637
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#2033331.608201992556590.003401274138723850.0173543245773697
FOSL2#2355182.192400078288560.001457060391505380.00933639672546967
FOXA1#3169272.152505994484940.0001136711313550550.00155653589715361
FOXA2#3170244.252741942906232.1972029910603e-091.8809318293717e-07
HDAC2#3066292.798942351526343.78007892975108e-071.84998905034805e-05
HEY1#23462551.598605088998668.22381484540393e-050.00123669834217299
HNF4A#3172284.659741943616579.82980288562775e-121.23095297790417e-09
HNF4G#3174255.171478871663091.68827079468272e-112.05024783169615e-09
RXRA#6256294.188229475070974.98562353858421e-115.61092173217884e-09
SP1#6667381.557830880355070.002725711042187930.014970053404242
TCF7L2#6934221.704632261791520.009361319214366260.0353517073123083



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

Retrieved from "http://f5-webapp4.gsc.riken.jp/resource_browser/index.php?title=Coexpression_cluster:C129&oldid=3067247"