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{{CL
{{CL
|id=CL:0000312
|alt_id=CL:0002185
|name=keratinocyte
|namespace=cell;;efo
|def="An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, MESH:A.11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116]
|xref=BTO:0000667;;FMA:62879
|is_a=CL:0000237;;CL:0000362;;EFO:0000700
|synonym="keratinized cell of epidermis" EXACT [];;"malpighian cell" EXACT []
|comment=Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
|comment=Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
|alt_id=CL:0002185
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, MESH:A.11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116]
|subset=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000312
|is_a=CL:0000237 ;;CL:0000362
|is_obsolete=
|located_in=
|located_in=
|part_of=
|name=keratinocyte
|namespace=FANTOM
|obo_creation_date=
|part_of=UBERON:0001003
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="keratinized cell of epidermis" EXACT [];;"malpighian cell" EXACT []
|union_of=
|xref=BTO:0000667;;FMA:62879
}}
}}

Latest revision as of 16:32, 12 September 2014

Name:keratinocyte
Namespace:FANTOM
Definition:"An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, MESH:A.11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116]
Xrefs:
links:

BTO:0000667

FMA:62879
Synonyms: "keratinized cell of epidermis" EXACT []
"malpighian cell" EXACT []
Comments:Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
Alt_id: CL:0002185


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000237(keratinizing barrier epithelial cell),CL:0000362(epidermal cell)
part_of:UBERON:0001003(skin epidermis)



Children


is a:CL:0000242 (Merkel cell)
derives from:FF:0000082 (human epidermal keratinocyte sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000312 (keratinocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.49e-79FFCP PHASE2:Hg19::chr1:40770344..40770353,-#_99c4594d4b8c5aea164195d6d4db5672p29@COL9A2
3.49e-79FFCP PHASE2:Hg19::chr3:66452082..66452087,-#_99c4594d4b8c5aea164195d6d4db5672p@chr3:66452082..66452087, -
3.49e-79FFCP PHASE1:Hg19::chr19:39401676..39401683,-#_99c4594d4b8c5aea164195d6d4db5672p@chr19:39401676..39401683, -
3.49e-79FFCP PHASE1:Hg19::chr9:139089234..139089236,-#_99c4594d4b8c5aea164195d6d4db5672p@chr9:139089234..139089236, -
3.49e-79FFCP PHASE1:Hg19::chr1:216196797..216196801,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:216196797..216196801, -
3.49e-79FFCP PHASE2:Hg19::chr20:49727833..49727839,-#_99c4594d4b8c5aea164195d6d4db5672p@chr20:49727833..49727839, -
3.49e-79FFCP PHASE2:Hg19::chr9:33719626..33719633,-#_99c4594d4b8c5aea164195d6d4db5672p@chr9:33719626..33719633, -
3.49e-79FFCP PHASE2:Hg19::chr15:46610847..46610851,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610847..46610851, +
3.49e-79FFCP PHASE1:Hg19::chr5:64369097..64369105,+#_99c4594d4b8c5aea164195d6d4db5672p@chr5:64369097..64369105, +
3.49e-79FFCP PHASE2:Hg19::chr4:6356121..6356152,-#_99c4594d4b8c5aea164195d6d4db5672p@chr4:6356121..6356152, -
3.49e-79FFCP PHASE1:Hg19::chr1:40770344..40770353,-#_99c4594d4b8c5aea164195d6d4db5672p29@COL9A2
3.49e-79FFCP PHASE2:Hg19::chr22:27043104..27043111,+#_99c4594d4b8c5aea164195d6d4db5672p27@MIAT
3.49e-79FFCP PHASE1:Hg19::chr11:79659013..79659021,-#_99c4594d4b8c5aea164195d6d4db5672p@chr11:79659013..79659021, -
3.49e-79FFCP PHASE2:Hg19::chr1:201288895..201288902,+#_99c4594d4b8c5aea164195d6d4db5672p@chr1:201288895..201288902, +
3.49e-79FFCP PHASE2:Hg19::chr11:79659013..79659021,-#_99c4594d4b8c5aea164195d6d4db5672p@chr11:79659013..79659021, -
3.49e-79FFCP PHASE1:Hg19::chr6:112466463..112466468,+#_99c4594d4b8c5aea164195d6d4db5672p@chr6:112466463..112466468, +
3.49e-79FFCP PHASE2:Hg19::chr1:216595350..216595395,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:216595350..216595395, -
3.49e-79FFCP PHASE1:Hg19::chr20:49727833..49727839,-#_99c4594d4b8c5aea164195d6d4db5672p@chr20:49727833..49727839, -
3.49e-79FFCP PHASE1:Hg19::chr9:33719626..33719633,-#_99c4594d4b8c5aea164195d6d4db5672p@chr9:33719626..33719633, -
3.49e-79FFCP PHASE1:Hg19::chr3:66452082..66452087,-#_99c4594d4b8c5aea164195d6d4db5672p@chr3:66452082..66452087, -
3.49e-79FFCP PHASE2:Hg19::chr15:46610897..46610904,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610897..46610904, +
3.49e-79FFCP PHASE2:Hg19::chr1:242843433..242843446,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:242843433..242843446, -
3.49e-79FFCP PHASE1:Hg19::chr15:46610847..46610851,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610847..46610851, +
3.49e-79FFCP PHASE1:Hg19::chr4:6356121..6356152,-#_99c4594d4b8c5aea164195d6d4db5672p@chr4:6356121..6356152, -
3.49e-79FFCP PHASE1:Hg19::chr22:27043104..27043111,+#_99c4594d4b8c5aea164195d6d4db5672p27@MIAT
3.49e-79FFCP PHASE1:Hg19::chr11:79659052..79659060,-#_99c4594d4b8c5aea164195d6d4db5672p@chr11:79659052..79659060, -
3.49e-79FFCP PHASE1:Hg19::chr1:201288895..201288902,+#_99c4594d4b8c5aea164195d6d4db5672p@chr1:201288895..201288902, +
3.49e-79FFCP PHASE2:Hg19::chr11:79659052..79659060,-#_99c4594d4b8c5aea164195d6d4db5672p@chr11:79659052..79659060, -
3.49e-79FFCP PHASE2:Hg19::chr15:46610951..46610964,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610951..46610964, +
3.49e-79FFCP PHASE1:Hg19::chr15:46610897..46610904,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610897..46610904, +
3.49e-79FFCP PHASE2:Hg19::chr1:216196797..216196801,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:216196797..216196801, -
3.49e-79FFCP PHASE1:Hg19::chr1:216595350..216595395,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:216595350..216595395, -
3.49e-79FFCP PHASE1:Hg19::chr1:242843433..242843446,-#_99c4594d4b8c5aea164195d6d4db5672p@chr1:242843433..242843446, -
3.49e-79FFCP PHASE2:Hg19::chr19:39401676..39401683,-#_99c4594d4b8c5aea164195d6d4db5672p@chr19:39401676..39401683, -
3.49e-79FFCP PHASE2:Hg19::chr9:139089234..139089236,-#_99c4594d4b8c5aea164195d6d4db5672p@chr9:139089234..139089236, -
3.49e-79FFCP PHASE1:Hg19::chr15:46610951..46610964,+#_99c4594d4b8c5aea164195d6d4db5672p@chr15:46610951..46610964, +
3.49e-79FFCP PHASE2:Hg19::chr5:64369097..64369105,+#_99c4594d4b8c5aea164195d6d4db5672p@chr5:64369097..64369105, +
3.49e-79FFCP PHASE2:Hg19::chr6:112466463..112466468,+#_99c4594d4b8c5aea164195d6d4db5672p@chr6:112466463..112466468, +
7.37e-60FFCP PHASE2:Hg19::chr1:16090914..16090925,+#_1465f29bf63f33c8f453141d23de64a4p22@FBLIM1
7.37e-60FFCP PHASE1:Hg19::chr1:16090914..16090925,+#_1465f29bf63f33c8f453141d23de64a4p22@FBLIM1
2.19e-53FFCP PHASE2:Hg19::chr5:145722450..145722456,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr5:145722450..145722456, +
2.19e-53FFCP PHASE2:Hg19::chr1:155048171..155048179,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr1:155048171..155048179, +
2.19e-53FFCP PHASE2:Hg19::chr16:53653257..53653264,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr16:53653257..53653264, -
2.19e-53FFCP PHASE1:Hg19::chr5:145722450..145722456,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr5:145722450..145722456, +
2.19e-53FFCP PHASE2:Hg19::chr12:65175253..65175283,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr12:65175253..65175283, -
2.19e-53FFCP PHASE1:Hg19::chr1:155048171..155048179,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr1:155048171..155048179, +
2.19e-53FFCP PHASE2:Hg19::chr1:155048200..155048207,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr1:155048200..155048207, +
2.19e-53FFCP PHASE2:Hg19::chr9:33719660..33719671,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr9:33719660..33719671, -
2.19e-53FFCP PHASE2:Hg19::chr22:35921483..35921490,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr22:35921483..35921490, -
2.19e-53FFCP PHASE1:Hg19::chr12:65175253..65175283,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr12:65175253..65175283, -
2.19e-53FFCP PHASE1:Hg19::chr16:53653257..53653264,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr16:53653257..53653264, -
2.19e-53FFCP PHASE2:Hg19::chr9:139096224..139096231,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr9:139096224..139096231, -
2.19e-53FFCP PHASE1:Hg19::chr1:155048200..155048207,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr1:155048200..155048207, +
2.19e-53FFCP PHASE1:Hg19::chr9:33719660..33719671,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr9:33719660..33719671, -
2.19e-53FFCP PHASE2:Hg19::chr5:64369069..64369083,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr5:64369069..64369083, +
2.19e-53FFCP PHASE1:Hg19::chr9:139096224..139096231,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr9:139096224..139096231, -
2.19e-53FFCP PHASE1:Hg19::chr22:35921483..35921490,-#_933a412cd2e4e0f70fee0c69008f9a58p@chr22:35921483..35921490, -
2.19e-53FFCP PHASE1:Hg19::chr11:128634589..128634606,+#_933a412cd2e4e0f70fee0c69008f9a58p14@FLI1
2.19e-53FFCP PHASE2:Hg19::chr11:128634589..128634606,+#_933a412cd2e4e0f70fee0c69008f9a58p14@FLI1
2.19e-53FFCP PHASE1:Hg19::chr5:64369069..64369083,+#_933a412cd2e4e0f70fee0c69008f9a58p@chr5:64369069..64369083, +
2.87e-53FFCP PHASE1:Hg19::chr11:31312513..31312524,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr11:31312513..31312524, -
2.87e-53FFCP PHASE2:Hg19::chr11:31312513..31312524,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr11:31312513..31312524, -
2.87e-53FFCP PHASE2:Hg19::chr5:14742023..14742037,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:14742023..14742037, -
2.87e-53FFCP PHASE2:Hg19::chr12:54786411..54786421,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr12:54786411..54786421, -
2.87e-53FFCP PHASE1:Hg19::chr1:216286476..216286479,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr1:216286476..216286479, -
2.87e-53FFCP PHASE2:Hg19::chr20:31116333..31116338,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr20:31116333..31116338, -
2.87e-53FFCP PHASE2:Hg19::chr2:3152671..3152679,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr2:3152671..3152679, -
2.87e-53FFCP PHASE2:Hg19::chr5:145724630..145724641,+#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:145724630..145724641, +
2.87e-53FFCP PHASE2:Hg19::chr20:49727891..49727898,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr20:49727891..49727898, -
2.87e-53FFCP PHASE1:Hg19::chr12:54786411..54786421,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr12:54786411..54786421, -
2.87e-53FFCP PHASE1:Hg19::chr5:14742023..14742037,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:14742023..14742037, -
2.87e-53FFCP PHASE1:Hg19::chr20:31116333..31116338,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr20:31116333..31116338, -
2.87e-53FFCP PHASE1:Hg19::chr2:3152671..3152679,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr2:3152671..3152679, -
2.87e-53FFCP PHASE1:Hg19::chr5:145724630..145724641,+#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:145724630..145724641, +
2.87e-53FFCP PHASE2:Hg19::chr5:145724642..145724652,+#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:145724642..145724652, +
2.87e-53FFCP PHASE1:Hg19::chr20:49727891..49727898,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr20:49727891..49727898, -
2.87e-53FFCP PHASE2:Hg19::chr18:13165683..13165695,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr18:13165683..13165695, -
2.87e-53FFCP PHASE1:Hg19::chr5:145724642..145724652,+#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr5:145724642..145724652, +
2.87e-53FFCP PHASE1:Hg19::chr18:13165683..13165695,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr18:13165683..13165695, -
2.87e-53FFCP PHASE2:Hg19::chr1:216286476..216286479,-#_4b76e6a62ae2b11b5ccc4f3051325cd5p@chr1:216286476..216286479, -
3.74e-53FFCP PHASE1:Hg19::chr3:77121235..77121260,+#_de4b25e0072976651eb698a0b9b88f38p@chr3:77121235..77121260, +
3.74e-53FFCP PHASE2:Hg19::chr7:1327587..1327610,+#_de4b25e0072976651eb698a0b9b88f38p@chr7:1327587..1327610, +
3.74e-53FFCP PHASE1:Hg19::chr7:1327587..1327610,+#_de4b25e0072976651eb698a0b9b88f38p@chr7:1327587..1327610, +
3.74e-53FFCP PHASE2:Hg19::chr7:1327611..1327629,+#_de4b25e0072976651eb698a0b9b88f38p@chr7:1327611..1327629, +
3.74e-53FFCP PHASE1:Hg19::chr7:1327611..1327629,+#_de4b25e0072976651eb698a0b9b88f38p@chr7:1327611..1327629, +
3.74e-53FFCP PHASE2:Hg19::chr3:77121235..77121260,+#_de4b25e0072976651eb698a0b9b88f38p@chr3:77121235..77121260, +
2.98e-45FFCP PHASE2:Hg19::chr4:87770202..87770211,-#_59fc133c22e8d2ec5f1de22d7be86a38p5@SLC10A6
2.98e-45FFCP PHASE1:Hg19::chr4:87770202..87770211,-#_59fc133c22e8d2ec5f1de22d7be86a38p5@SLC10A6
1.48e-40FFCP PHASE1:Hg19::chr22:35568509..35568524,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr22:35568509..35568524, -
1.48e-40FFCP PHASE2:Hg19::chr22:35568566..35568568,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr22:35568566..35568568, -
1.48e-40FFCP PHASE1:Hg19::chr5:145808948..145808956,+#_3a34ab249a6468dcc3fda4d3290bfe32p@chr5:145808948..145808956, +
1.48e-40FFCP PHASE1:Hg19::chr9:104302091..104302134,+#_3a34ab249a6468dcc3fda4d3290bfe32p@chr9:104302091..104302134, +
1.48e-40FFCP PHASE1:Hg19::chr11:88953463..88953464,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr11:88953463..88953464, -
1.48e-40FFCP PHASE2:Hg19::chr12:52840487..52840511,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr12:52840487..52840511, -
1.48e-40FFCP PHASE1:Hg19::chr4:173606828..173606840,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr4:173606828..173606840, -
1.48e-40FFCP PHASE2:Hg19::chr3:140784752..140784757,+#_3a34ab249a6468dcc3fda4d3290bfe32p10@SPSB4
1.48e-40FFCP PHASE2:Hg19::chr11:88953463..88953464,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr11:88953463..88953464, -
1.48e-40FFCP PHASE2:Hg19::chr4:82619895..82619898,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr4:82619895..82619898, -
1.48e-40FFCP PHASE1:Hg19::chr13:112161853..112161860,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr13:112161853..112161860, -
1.48e-40FFCP PHASE2:Hg19::chr2:197081754..197081790,-#_3a34ab249a6468dcc3fda4d3290bfe32p@chr2:197081754..197081790, -

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