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{{Coexpression_clusters
{
|full_id=C845_Alveolar_Hair_Olfactory_Osteoblast_Endothelial_Fibroblast_Smooth

Latest revision as of 11:32, 17 September 2013


Full id: C845_Alveolar_Hair_Olfactory_Osteoblast_Endothelial_Fibroblast_Smooth



Phase1 CAGE Peaks

Hg19::chr17:79477707..79477767,-p@chr17:79477707..79477767
-
Hg19::chr17:79477834..79477869,-p@chr17:79477834..79477869
-
Hg19::chr17:79478024..79478066,-p@chr17:79478024..79478066
-
Hg19::chr17:79478430..79478482,-p5@ACTG1
Hg19::chr17:79478506..79478548,-p4@ACTG1
Hg19::chr17:79478583..79478611,-p7@ACTG1
Hg19::chr17:79478983..79479046,-p6@ACTG1
Hg19::chr17:79479105..79479174,-p3@ACTG1
Hg19::chr17:79479285..79479321,-p2@ACTG1
Hg19::chr17:79479370..79479375,-p10@ACTG1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
vasculature2.58e-1378
vascular system2.58e-1378
epithelial vesicle5.21e-1378
artery1.64e-1142
arterial blood vessel1.64e-1142
arterial system1.64e-1142
epithelial tube open at both ends1.83e-1159
blood vessel1.83e-1159
blood vasculature1.83e-1159
vascular cord1.83e-1159
multilaminar epithelium2.02e-1183
vessel5.54e-1168
dense mesenchyme tissue1.23e-1073
somite1.26e-1071
presomitic mesoderm1.26e-1071
presumptive segmental plate1.26e-1071
dermomyotome1.26e-1071
trunk paraxial mesoderm1.26e-1071
paraxial mesoderm3.30e-1072
presumptive paraxial mesoderm3.30e-1072
splanchnic layer of lateral plate mesoderm4.49e-1083
mesoderm9.76e-10315
mesoderm-derived structure9.76e-10315
presumptive mesoderm9.76e-10315
epithelial tube1.67e-09117
unilaminar epithelium2.67e-09148
skeletal muscle tissue7.91e-0962
striated muscle tissue7.91e-0962
myotome7.91e-0962
muscle tissue2.08e-0864
musculature2.08e-0864
musculature of body2.08e-0864
cardiovascular system4.59e-08109
systemic artery1.12e-0733
systemic arterial system1.12e-0733
trunk mesenchyme1.99e-07122
circulatory system2.54e-07112


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0586157
MA0004.10.380329
MA0006.10.236135
MA0007.10.363007
MA0009.10.828613
MA0014.10.284587
MA0017.10.270554
MA0019.10.520264
MA0024.10.725404
MA0025.12.20595
MA0027.12.43535
MA0028.10.25013
MA0029.10.744375
MA0030.10.733118
MA0031.10.669876
MA0038.10.477043
MA0040.10.750125
MA0041.10.397617
MA0042.10.367902
MA0043.10.828925
MA0046.10.817858
MA0048.10.0613414
MA0050.10.368721
MA0051.10.473017
MA0052.10.753928
MA0055.10.014035
MA0056.10
MA0057.10.0580131
MA0058.10.293055
MA0059.10.291897
MA0060.10.138988
MA0061.10.118318
MA0063.10
MA0066.12.08608
MA0067.11.1435
MA0068.10.0911063
MA0069.10.814052
MA0070.10.803003
MA0071.11.12112
MA0072.10.798564
MA0073.10.0824235
MA0074.10.4723
MA0076.10.307383
MA0077.10.790956
MA0078.12.38506
MA0081.10.292043
MA0083.10.836033
MA0084.11.32998
MA0087.10.79615
MA0088.10.300184
MA0089.10
MA0090.10.320494
MA0091.10.382762
MA0092.10.918839
MA0093.10.238771
MA0095.10
MA0098.10
MA0100.11.2287
MA0101.10.241637
MA0103.10.646502
MA0105.10.189717
MA0106.10.516528
MA0107.10.179177
MA0108.20.666881
MA0109.10
MA0111.10.33284
MA0113.11.31824
MA0114.10.174997
MA0115.11.06753
MA0116.10.182037
MA0117.12.01191
MA0119.10.277531
MA0122.10.891407
MA0124.11.0263
MA0125.10.942948
MA0130.10
MA0131.10.585907
MA0132.10
MA0133.10
MA0135.10.858623
MA0136.10.483775
MA0139.10.353333
MA0140.10.437738
MA0141.10.789887
MA0142.10.638837
MA0143.11.3186
MA0144.11.51733
MA0145.10.602634
MA0146.10.853075
MA0147.10.184931
MA0148.10.403564
MA0149.10.428597
MA0062.20.114378
MA0035.20.437071
MA0039.20.138005
MA0138.20.569505
MA0002.20.129981
MA0137.20.255808
MA0104.20.138396
MA0047.20.504873
MA0112.21.75318
MA0065.20.0371828
MA0150.11.52802
MA0151.10
MA0152.10.443956
MA0153.10.926242
MA0154.10.0494985
MA0155.10.12484
MA0156.10.257809
MA0157.10.612166
MA0158.10
MA0159.10.185458
MA0160.10.417847
MA0161.10
MA0162.10.403951
MA0163.10.715303
MA0164.10.544294
MA0080.20.238846
MA0018.20.517858
MA0099.20.444294
MA0079.20.0179307
MA0102.21.36707
MA0258.11.47203
MA0259.10.560522
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066494.824230735767522.27590399695328e-068.12626111240356e-05
ETS1#211343.891504368880930.01407798708438330.0494032758679447
HEY1#2346272.8280777301740.003295391007019310.0170498038929005
PBX3#509048.765805074697650.000728667835365060.00581059327003829
POLR2A#5430102.147453176558070.0004793377491637920.00436646796205122
RDBP#7936230.7276807980050.001839920449249570.0108884548843594
SIN3A#25942105.408884726815144.66075745019938e-083.04228029588358e-06
SP1#666763.419028826884540.003207339839120720.0168225876585942
TAF7#687978.003148583446743.69807928210857e-060.000121111226762037
ZBTB33#10009825.33178002398494.18691723397733e-114.76337090413244e-09



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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