Coexpression cluster:C756

Full id: C756_Eosinophils_Natural_CD8_CD14_CD4_Basophils_Neutrophils

Phase1 CAGE Peaks

Hg19::chr14:35343724..35343735,+	p7@ENST00000557373
Hg19::chr14:52313589..52313620,-	p@chr14:52313589..52313620 -
Hg19::chr16:31086162..31086174,+	p@chr16:31086162..31086174 +
Hg19::chr16:88522520..88522537,-	p@chr16:88522520..88522537 -
Hg19::chr17:57696541..57696548,-	p@chr17:57696541..57696548 -
Hg19::chr19:13958525..13958536,+	p@chr19:13958525..13958536 +
Hg19::chr1:198648829..198648838,-	p2@ENST00000455475
Hg19::chr1:53099124..53099132,-	p@chr1:53099124..53099132 -
Hg19::chr2:208395615..208395626,-	p@chr2:208395615..208395626 -
Hg19::chrX:48776819..48776823,-	p5@PIM2
Hg19::chrX:70338312..70338315,-	p@chrX:70338312..70338315 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007140	male meiosis	0.012981278700106
GO:0008637	apoptotic mitochondrial changes	0.0176174496644295
GO:0051327	M phase of meiotic cell cycle	0.0235782409042741
GO:0007126	meiosis	0.0235782409042741
GO:0051321	meiotic cell cycle	0.0235782409042741
GO:0008632	apoptotic program	0.0235782409042741
GO:0007005	mitochondrion organization and biogenesis	0.0235782409042741
GO:0006916	anti-apoptosis	0.0394074531967503
GO:0043066	negative regulation of apoptosis	0.0426527728717768
GO:0043069	negative regulation of programmed cell death	0.0426527728717768

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.12e-50	140
hematopoietic stem cell	2.27e-48	172
angioblastic mesenchymal cell	2.27e-48	172
hematopoietic cell	7.30e-46	182
hematopoietic oligopotent progenitor cell	1.27e-43	165
hematopoietic multipotent progenitor cell	1.27e-43	165
hematopoietic lineage restricted progenitor cell	7.40e-40	124
nongranular leukocyte	2.55e-39	119
lymphocyte	2.97e-25	53
common lymphoid progenitor	2.97e-25	53
lymphoid lineage restricted progenitor cell	5.79e-25	52
CD14-positive, CD16-negative classical monocyte	6.61e-22	42
classical monocyte	1.07e-21	45
myeloid leukocyte	1.82e-19	76
myeloid cell	6.15e-19	112
common myeloid progenitor	6.15e-19	112
granulocyte monocyte progenitor cell	4.05e-17	71
myeloid lineage restricted progenitor cell	1.94e-14	70
macrophage dendritic cell progenitor	4.16e-14	65
mature alpha-beta T cell	8.97e-14	18
alpha-beta T cell	8.97e-14	18
immature T cell	8.97e-14	18
mature T cell	8.97e-14	18
immature alpha-beta T cell	8.97e-14	18
monopoietic cell	5.61e-13	63
monocyte	5.61e-13	63
monoblast	5.61e-13	63
promonocyte	5.61e-13	63
T cell	2.16e-12	25
pro-T cell	2.16e-12	25
lymphocyte of B lineage	2.26e-11	24
pro-B cell	2.26e-11	24
mesenchymal cell	1.00e-09	358
motile cell	6.75e-09	390
connective tissue cell	1.11e-08	365
CD8-positive, alpha-beta T cell	1.34e-08	11
B cell	2.79e-08	14
intermediate monocyte	2.40e-07	9
CD14-positive, CD16-positive monocyte	2.40e-07	9

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.79e-23	102
blood island	3.79e-23	102
hemolymphoid system	5.65e-20	112
bone marrow	2.15e-16	80
bone element	5.52e-15	86
immune system	3.02e-13	115
skeletal element	6.29e-11	101
skeletal system	6.29e-11	101
connective tissue	2.04e-08	375

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	7	3.1228840458323	0.00220424714517552	0.0127012064879992
EBF1#1879	5	4.04839402116773	0.00459238325242163	0.0217044037695566
NFKB1#4790	7	3.49240399721426	0.00110207548522866	0.0076969146450312

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.