MCL coexpression mm9:1248

Phase1 CAGE Peaks

	Short description
Mm9::chr10:6893990..6894006,-	p@chr10:6893990..6894006 -
Mm9::chr10:6955274..6955276,-	p@chr10:6955274..6955276 -
Mm9::chr14:102293240..102293254,+	p@chr14:102293240..102293254 +
Mm9::chr16:38622460..38622476,-	p@chr16:38622460..38622476 -
Mm9::chr5:77544170..77544181,-	p6@Hopx
Mm9::chr9:30750126..30750131,+	p1@Adamts8

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043416	regulation of skeletal muscle regeneration	0.00575216387474856
GO:0043415	positive regulation of skeletal muscle regeneration	0.00575216387474856
GO:0051149	positive regulation of muscle cell differentiation	0.00575216387474856
GO:0051155	positive regulation of striated muscle cell differentiation	0.00575216387474856
GO:0051153	regulation of striated muscle cell differentiation	0.00575216387474856
GO:0043403	skeletal muscle regeneration	0.00575216387474856
GO:0051147	regulation of muscle cell differentiation	0.00657372147411718
GO:0031099	regeneration	0.0140577633669742
GO:0042246	tissue regeneration	0.0140577633669742
GO:0051146	striated muscle cell differentiation	0.0333387866712209
GO:0045597	positive regulation of cell differentiation	0.0459605804354191
GO:0048589	developmental growth	0.0459605804354191

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	7.65e-11	18
heart	7.65e-11	18
primitive heart tube	7.65e-11	18
primary heart field	7.65e-11	18
anterior lateral plate mesoderm	7.65e-11	18
heart tube	7.65e-11	18
heart primordium	7.65e-11	18
cardiac mesoderm	7.65e-11	18
cardiogenic plate	7.65e-11	18
heart rudiment	7.65e-11	18
lung	1.11e-10	14
respiratory tube	1.11e-10	14
respiration organ	1.11e-10	14
pair of lungs	1.11e-10	14
lung primordium	1.11e-10	14
lung bud	1.11e-10	14
epithelial bud	1.23e-07	17
thoracic cavity element	1.23e-07	17
thoracic segment organ	1.23e-07	17
thoracic cavity	1.23e-07	17
thoracic segment of trunk	1.23e-07	17
respiratory primordium	1.23e-07	17
endoderm of foregut	1.23e-07	17
cardiovascular system	1.43e-07	23
circulatory system	1.43e-07	23
compound organ	3.32e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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