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Revision as of 17:13, 15 June 2012

Name:substantia propria of cornea
Definition:"The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. It is composed of about 200 flattened lamellテヲ (plates of collagen fibrils), superimposed one on another. They are each about 1.5-2.5 micrometres in thickness. These fibrils run at different angles between the limbi. Fibres of the layers frequently interweave, the anterior lamellテヲ interweaving more than posterior lamellテヲ. The fibres of each lamella are parallel with one another, but at right angles to those of adjacent lamellテヲ. The lamellテヲ are produced by keratocytes (corneal corpuscles), which occupy about 10% of the substantia propria. These lamellテヲ are made up of bundles of modified connective tissue, the fibres of which are directly continuous with those of the sclera. More collagen fibres run in a temporal-nasal direction than run in the superior-inferior direction. This is often ignored by corneal transplant surgeons, leading to poor corneal mechanical strength in corneal transplant patients. [WP,unvetted]." [Wikipedia:Corneal_stroma]
Xrefs:
links:

EFO:0002514
EMAPA:17602
FMA:58306
GAID:893
[ 200px-Gray871.png 200px-Gray871.png]
MA:0001245
MESH:A.09.371.060.217.228
ncithesaurus:Corneal_Stroma
SCTID:362511000

ZFA:0001685
Synonyms: "corneal stroma" EXACT []
"stroma of cornea" EXACT []
"substantia propria" RELATED []
Comments:This class was created automatically from a combination of ontologies
Alt_id: UBERON:FMA_58306-MA_0001245
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:UBERON:0003566(head connective tissue),UBERON:0003891(stroma),UBERON:0004121(ectoderm-derived structure)
part_of:UBERON:0000964(cornea)



Children

part of:CL:0002363 (keratocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology


Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001777 (substantia propria of cornea), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data


P-valueFFCPShort description
1.55e-98FFCP PHASE2:Hg19::chr3:52362029..52362031,+#_30f7b30922b07b3050d9176a9b5d85eap@chr3:52362029..52362031, +
1.55e-98FFCP PHASE1:Hg19::chr3:52362029..52362031,+#_30f7b30922b07b3050d9176a9b5d85eap@chr3:52362029..52362031, +
1.55e-98FFCP PHASE2:Hg19::chr7:150910973..150910976,-#_30f7b30922b07b3050d9176a9b5d85eap@chr7:150910973..150910976, -
1.55e-98FFCP PHASE1:Hg19::chr7:150910973..150910976,-#_30f7b30922b07b3050d9176a9b5d85eap@chr7:150910973..150910976, -
4.52e-50FFCP PHASE2:Hg19::chr6:113369869..113369877,+#_1bbd5c58093665e40218473c455f369dp@chr6:113369869..113369877, +
4.52e-50FFCP PHASE2:Hg19::chr10:92617531..92617541,-#_1bbd5c58093665e40218473c455f369dp8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr10:92617531..92617541,-#_1bbd5c58093665e40218473c455f369dp8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr6:113369869..113369877,+#_1bbd5c58093665e40218473c455f369dp@chr6:113369869..113369877, +
4.52e-50FFCP PHASE2:Hg19::chr15:49255230..49255248,-#_1bbd5c58093665e40218473c455f369dp16@SHC4
4.52e-50FFCP PHASE1:Hg19::chr15:49255230..49255248,-#_1bbd5c58093665e40218473c455f369dp16@SHC4
4.52e-50FFCP PHASE2:Hg19::chr8:22932230..22932233,-#_1bbd5c58093665e40218473c455f369dp5@ENST00000520840, p5@ENST00000523806
4.52e-50FFCP PHASE1:Hg19::chr8:22932230..22932233,-#_1bbd5c58093665e40218473c455f369dp5@ENST00000520840, p5@ENST00000523806
5.04e-34FFCP PHASE2:Hg19::chr1:44820685..44820695,-#_aba62d1b9ef569dcb04ef444be94a928p10@ERI3
5.04e-34FFCP PHASE2:Hg19::chr6:151770193..151770196,-#_aba62d1b9ef569dcb04ef444be94a928p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE1:Hg19::chr1:44820685..44820695,-#_aba62d1b9ef569dcb04ef444be94a928p10@ERI3
5.04e-34FFCP PHASE1:Hg19::chr6:151770193..151770196,-#_aba62d1b9ef569dcb04ef444be94a928p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE2:Hg19::chr21:47410794..47410799,+#_aba62d1b9ef569dcb04ef444be94a928p@chr21:47410794..47410799, +
5.04e-34FFCP PHASE1:Hg19::chr21:47410794..47410799,+#_aba62d1b9ef569dcb04ef444be94a928p@chr21:47410794..47410799, +
7.05e-34FFCP PHASE1:Hg19::chr10:43133595..43133606,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:43133595..43133606, -
7.05e-34FFCP PHASE1:Hg19::chr2:25383828..25383855,-#_b5550821167fa927230b8bf46d90a4a9p4@POMC
7.05e-34FFCP PHASE2:Hg19::chr10:74020629..74020634,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:74020629..74020634, -
7.05e-34FFCP PHASE1:Hg19::chr1:9970194..9970195,-#_b5550821167fa927230b8bf46d90a4a9p14@CTNNBIP1
7.05e-34FFCP PHASE1:Hg19::chr10:74020629..74020634,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:74020629..74020634, -
7.05e-34FFCP PHASE2:Hg19::chr5:79375654..79375674,+#_b5550821167fa927230b8bf46d90a4a9p@chr5:79375654..79375674, +
7.05e-34FFCP PHASE1:Hg19::chr5:79375654..79375674,+#_b5550821167fa927230b8bf46d90a4a9p@chr5:79375654..79375674, +
7.05e-34FFCP PHASE1:Hg19::chr11:65265332..65265342,+#_b5550821167fa927230b8bf46d90a4a9p19@MALAT1
7.05e-34FFCP PHASE2:Hg19::chr15:101459410..101459421,-#_b5550821167fa927230b8bf46d90a4a9p2@ENST00000560068
7.05e-34FFCP PHASE2:Hg19::chr11:65265332..65265342,+#_b5550821167fa927230b8bf46d90a4a9p19@MALAT1
7.05e-34FFCP PHASE1:Hg19::chr15:101459410..101459421,-#_b5550821167fa927230b8bf46d90a4a9p2@ENST00000560068
7.05e-34FFCP PHASE2:Hg19::chr2:25383828..25383855,-#_b5550821167fa927230b8bf46d90a4a9p4@POMC
7.05e-34FFCP PHASE2:Hg19::chr1:9970194..9970195,-#_b5550821167fa927230b8bf46d90a4a9p14@CTNNBIP1
7.05e-34FFCP PHASE2:Hg19::chr10:43133595..43133606,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:43133595..43133606, -
6.41e-31FFCP PHASE2:Hg19::chr4:111536534..111536575,-#_8b16d2da7d04c381833ab6d4a3d4191fp1@ENST00000503456
6.41e-31FFCP PHASE1:Hg19::chr4:111536534..111536575,-#_8b16d2da7d04c381833ab6d4a3d4191fp1@ENST00000503456
4.55e-29FFCP PHASE2:Hg19::chrX:19688475..19688492,-#_72b8f44f4f9c9883b82a3be157be9b49p26@SH3KBP1
4.55e-29FFCP PHASE1:Hg19::chrX:19688475..19688492,-#_72b8f44f4f9c9883b82a3be157be9b49p26@SH3KBP1
9.18e-26FFCP PHASE2:Hg19::chr21:47397571..47397582,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47397571..47397582, -
9.18e-26FFCP PHASE1:Hg19::chr4:57522753..57522760,-#_53de05d9a3c9c8f56c37ffadd63fef2cp18@HOPX
9.18e-26FFCP PHASE1:Hg19::chr2:219540880..219540912,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr2:219540880..219540912, +
9.18e-26FFCP PHASE1:Hg19::chr21:47397571..47397582,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47397571..47397582, -
9.18e-26FFCP PHASE1:Hg19::chr12:53693440..53693450,-#_53de05d9a3c9c8f56c37ffadd63fef2cp2@CU687581
9.18e-26FFCP PHASE2:Hg19::chr4:73434498..73434509,-#_53de05d9a3c9c8f56c37ffadd63fef2cp6@ADAMTS3
9.18e-26FFCP PHASE2:Hg19::chr17:30185971..30185986,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@C17orf79
9.18e-26FFCP PHASE2:Hg19::chr12:53693440..53693450,-#_53de05d9a3c9c8f56c37ffadd63fef2cp2@CU687581
9.18e-26FFCP PHASE2:Hg19::chr10:86153606..86153623,+#_53de05d9a3c9c8f56c37ffadd63fef2cp9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr1:93646042..93646043,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@TMED5
9.18e-26FFCP PHASE1:Hg19::chr10:86153606..86153623,+#_53de05d9a3c9c8f56c37ffadd63fef2cp9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr11:34073641..34073656,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr11:34073641..34073656, -
9.18e-26FFCP PHASE2:Hg19::chr20:60758060..60758074,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr20:60758060..60758074, -
9.18e-26FFCP PHASE2:Hg19::chr1:151171326..151171337,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr1:151171326..151171337, -
9.18e-26FFCP PHASE1:Hg19::chr11:34073641..34073656,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr11:34073641..34073656, -
9.18e-26FFCP PHASE1:Hg19::chr17:30185971..30185986,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@C17orf79
9.18e-26FFCP PHASE1:Hg19::chr1:93646042..93646043,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@TMED5
9.18e-26FFCP PHASE2:Hg19::chr7:6049190..6049209,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:6049190..6049209, +
9.18e-26FFCP PHASE2:Hg19::chr4:120546882..120546885,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr4:120546882..120546885, -
9.18e-26FFCP PHASE2:Hg19::chr1:179335101..179335112,+#_53de05d9a3c9c8f56c37ffadd63fef2cp6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr4:73434498..73434509,-#_53de05d9a3c9c8f56c37ffadd63fef2cp6@ADAMTS3
9.18e-26FFCP PHASE1:Hg19::chr20:60758060..60758074,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr20:60758060..60758074, -
9.18e-26FFCP PHASE2:Hg19::chr3:9956047..9956079,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr3:9956047..9956079, +
9.18e-26FFCP PHASE2:Hg19::chr1:36024782..36024791,+#_53de05d9a3c9c8f56c37ffadd63fef2cp4@AB383919
9.18e-26FFCP PHASE1:Hg19::chr4:120546882..120546885,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr4:120546882..120546885, -
9.18e-26FFCP PHASE1:Hg19::chr7:6049190..6049209,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:6049190..6049209, +
9.18e-26FFCP PHASE1:Hg19::chr1:179335101..179335112,+#_53de05d9a3c9c8f56c37ffadd63fef2cp6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr3:9956047..9956079,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr3:9956047..9956079, +
9.18e-26FFCP PHASE1:Hg19::chr1:151171326..151171337,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr1:151171326..151171337, -
9.18e-26FFCP PHASE2:Hg19::chr21:47681190..47681194,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47681190..47681194, -
9.18e-26FFCP PHASE2:Hg19::chr16:10590513..10590515,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr16:10590513..10590515, -
9.18e-26FFCP PHASE1:Hg19::chr1:36024782..36024791,+#_53de05d9a3c9c8f56c37ffadd63fef2cp4@AB383919
9.18e-26FFCP PHASE2:Hg19::chr4:57522753..57522760,-#_53de05d9a3c9c8f56c37ffadd63fef2cp18@HOPX
9.18e-26FFCP PHASE1:Hg19::chr21:47681190..47681194,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47681190..47681194, -
9.18e-26FFCP PHASE1:Hg19::chr16:10590513..10590515,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr16:10590513..10590515, -
9.18e-26FFCP PHASE2:Hg19::chr15:90344775..90344794,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr15:90344775..90344794, +
9.18e-26FFCP PHASE2:Hg19::chr7:100806199..100806216,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:100806199..100806216, -
9.18e-26FFCP PHASE1:Hg19::chr15:90344775..90344794,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr15:90344775..90344794, +
9.18e-26FFCP PHASE2:Hg19::chr2:219540880..219540912,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr2:219540880..219540912, +
9.18e-26FFCP PHASE1:Hg19::chr7:100806199..100806216,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:100806199..100806216, -
6.02e-24FFCP PHASE2:Hg19::chr1:145589059..145589070,-#_449cd59297011b978ac9c00cb5d621f6p3@NUDT17
6.02e-24FFCP PHASE1:Hg19::chr1:145589059..145589070,-#_449cd59297011b978ac9c00cb5d621f6p3@NUDT17
3.81e-21FFCP PHASE2:Hg19::chr17:19648416..19648426,-#_c643b3bbedb7ca9a2b69caa0557e7e3ep13@ALDH3A1
3.81e-21FFCP PHASE1:Hg19::chr17:19648416..19648426,-#_c643b3bbedb7ca9a2b69caa0557e7e3ep13@ALDH3A1
4.66e-21FFCP PHASE2:Hg19::chr6:41562324..41562340,+#_a132959ce27ce8b4e0be0ff5504fbf07p16@FOXP4
4.66e-21FFCP PHASE1:Hg19::chr6:41562324..41562340,+#_a132959ce27ce8b4e0be0ff5504fbf07p16@FOXP4
4.66e-21FFCP PHASE2:Hg19::chr4:52917466..52917498,-#_a132959ce27ce8b4e0be0ff5504fbf07p@chr4:52917466..52917498, -
4.66e-21FFCP PHASE1:Hg19::chr4:52917466..52917498,-#_a132959ce27ce8b4e0be0ff5504fbf07p@chr4:52917466..52917498, -
5.7e-21FFCP PHASE1:Hg19::chr8:27686258..27686262,-#_6827444bb6735ba3e4bf22b13bf4646bp@chr8:27686258..27686262, -
5.7e-21FFCP PHASE2:Hg19::chr19:48244695..48244702,+#_6827444bb6735ba3e4bf22b13bf4646bp14@EHD2
5.7e-21FFCP PHASE1:Hg19::chr12:58141331..58141342,+#_6827444bb6735ba3e4bf22b13bf4646bp@chr12:58141331..58141342, +
5.7e-21FFCP PHASE2:Hg19::chr12:58141331..58141342,+#_6827444bb6735ba3e4bf22b13bf4646bp@chr12:58141331..58141342, +
5.7e-21FFCP PHASE1:Hg19::chr19:48244695..48244702,+#_6827444bb6735ba3e4bf22b13bf4646bp14@EHD2
5.7e-21FFCP PHASE2:Hg19::chr5:142254452..142254462,+#_6827444bb6735ba3e4bf22b13bf4646bp29@ARHGAP26
5.7e-21FFCP PHASE1:Hg19::chr5:142254452..142254462,+#_6827444bb6735ba3e4bf22b13bf4646bp29@ARHGAP26
5.7e-21FFCP PHASE2:Hg19::chr7:73118172..73118185,-#_6827444bb6735ba3e4bf22b13bf4646bp3@STX1A
5.7e-21FFCP PHASE1:Hg19::chr7:73118172..73118185,-#_6827444bb6735ba3e4bf22b13bf4646bp3@STX1A
5.7e-21FFCP PHASE2:Hg19::chr8:27686258..27686262,-#_6827444bb6735ba3e4bf22b13bf4646bp@chr8:27686258..27686262, -
6.96e-21FFCP PHASE2:Hg19::chr6:50786414..50786426,+#_3b19ef7bdbfd9a808b1be5d581addf21p7@TFAP2B
6.96e-21FFCP PHASE1:Hg19::chr19:893600..893603,+#_3b19ef7bdbfd9a808b1be5d581addf21p@chr19:893600..893603, +
6.96e-21FFCP PHASE1:Hg19::chr6:50786414..50786426,+#_3b19ef7bdbfd9a808b1be5d581addf21p7@TFAP2B
6.96e-21FFCP PHASE2:Hg19::chr5:6766044..6766055,+#_3b19ef7bdbfd9a808b1be5d581addf21p2@ENST00000506093
6.96e-21FFCP PHASE1:Hg19::chr12:102455905..102455915,-#_3b19ef7bdbfd9a808b1be5d581addf21p5@CCDC53
6.96e-21FFCP PHASE2:Hg19::chr4:111563076..111563124,-#_3b19ef7bdbfd9a808b1be5d581addf21p8@PITX2