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|name=substantia propria of cornea
|name=substantia propria of cornea
|namespace=
|namespace=
|def="The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. It is composed of about 200 flattened lamellﾃｦ (plates of collagen fibrils), superimposed one on another. They are each about 1.5-2.5 micrometres in thickness. These fibrils run at different angles between the limbi. Fibres of the layers frequently interweave, the anterior lamellﾃｦ interweaving more than posterior lamellﾃｦ. The fibres of each lamella are parallel with one another, but at right angles to those of adjacent lamellﾃｦ. The lamellﾃｦ are produced by keratocytes (corneal corpuscles), which occupy about 10% of the substantia propria. These lamellﾃｦ are made up of bundles of modified connective tissue, the fibres of which are directly continuous with those of the sclera. More collagen fibres run in a temporal-nasal direction than run in the superior-inferior direction. This is often ignored by corneal transplant surgeons, leading to poor corneal mechanical strength in corneal transplant patients. [WP,unvetted]." [Wikipedia:Corneal_stroma]
|def="The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. It is composed of about 200 flattened lamell��ｽｦ (plates of collagen fibrils), superimposed one on another. They are each about 1.5-2.5 micrometres in thickness. These fibrils run at different angles between the limbi. Fibres of the layers frequently interweave, the anterior lamell��ｽｦ interweaving more than posterior lamell��ｽｦ. The fibres of each lamella are parallel with one another, but at right angles to those of adjacent lamell��ｽｦ. The lamell��ｽｦ are produced by keratocytes (corneal corpuscles), which occupy about 10% of the substantia propria. These lamell��ｽｦ are made up of bundles of modified connective tissue, the fibres of which are directly continuous with those of the sclera. More collagen fibres run in a temporal-nasal direction than run in the superior-inferior direction. This is often ignored by corneal transplant surgeons, leading to poor corneal mechanical strength in corneal transplant patients. [WP,unvetted]." [Wikipedia:Corneal_stroma]
|xref=EFO:0002514;;EMAPA:17602;;FMA:58306;;GAID:893;;http://upload.wikimedia.org/wikipedia/commons/thumb/6/66/Gray871.png/200px-Gray871.png;;MA:0001245;;MESH:A.09.371.060.217.228;;ncithesaurus:Corneal_Stroma;;SCTID:362511000;;ZFA:0001685
|xref=EFO:0002514;;EMAPA:17602;;FMA:58306;;GAID:893;;http://upload.wikimedia.org/wikipedia/commons/thumb/6/66/Gray871.png/200px-Gray871.png;;MA:0001245;;MESH:A.09.371.060.217.228;;ncithesaurus:Corneal_Stroma;;SCTID:362511000;;TAO:0002189;;ZFA:0001685
|is_a=UBERON:0003566;;UBERON:0003891;;UBERON:0004121
|is_a=UBERON:0003566;;UBERON:0003891;;UBERON:0010313
|synonym="corneal stroma" EXACT [];;"stroma of cornea" EXACT [];;"substantia propria" RELATED []
|synonym="cornea stroma" EXACT [];;"corneal stroma" EXACT [];;"stroma of cornea" EXACT [];;"substantia propria" RELATED []
|comment=This class was created automatically from a combination of ontologies
|comment=This class was created automatically from a combination of ontologies
|alt_id=UBERON:FMA_58306-MA_0001245
|alt_id=UBERON:FMA_58306-MA_0001245
Line 14: Line 14:
|obo_creation_date=
|obo_creation_date=
|subset=uberon_slim;;vertebrate_core
|subset=uberon_slim;;vertebrate_core
|adjacent_to=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|has_quality=
|has_quality=
|located_in=
|located_in=
|part_of=UBERON:0000964
|part_of=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.obo.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string
|is_obsolete=
|is_obsolete=
|preceded_by=
|preceded_by=
}}
}}

Revision as of 16:59, 26 June 2012

Name:substantia propria of cornea
Definition:"The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. It is composed of about 200 flattened lamell��ｽｦ (plates of collagen fibrils), superimposed one on another. They are each about 1.5-2.5 micrometres in thickness. These fibrils run at different angles between the limbi. Fibres of the layers frequently interweave, the anterior lamell��ｽｦ interweaving more than posterior lamell��ｽｦ. The fibres of each lamella are parallel with one another, but at right angles to those of adjacent lamell��ｽｦ. The lamell��ｽｦ are produced by keratocytes (corneal corpuscles), which occupy about 10% of the substantia propria. These lamell��ｽｦ are made up of bundles of modified connective tissue, the fibres of which are directly continuous with those of the sclera. More collagen fibres run in a temporal-nasal direction than run in the superior-inferior direction. This is often ignored by corneal transplant surgeons, leading to poor corneal mechanical strength in corneal transplant patients. [WP,unvetted]." [Wikipedia:Corneal_stroma]
Xrefs:
links:

EFO:0002514
EMAPA:17602
FMA:58306
GAID:893
[ 200px-Gray871.png 200px-Gray871.png]
MA:0001245
MESH:A.09.371.060.217.228
ncithesaurus:Corneal_Stroma
SCTID:362511000
TAO:0002189

ZFA:0001685
Synonyms: "cornea stroma" EXACT []
"corneal stroma" EXACT []
"stroma of cornea" EXACT []
"substantia propria" RELATED []
Comments:This class was created automatically from a combination of ontologies
Alt_id: UBERON:FMA_58306-MA_0001245
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0003566(head connective tissue),UBERON:0003891(stroma),UBERON:0010313(neural crest-derived structure)



Children

part of:CL:0002363 (keratocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001777 (substantia propria of cornea), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.55e-98FFCP PHASE2:Hg19::chr3:52362029..52362031,+#_30f7b30922b07b3050d9176a9b5d85eap@chr3:52362029..52362031, +
1.55e-98FFCP PHASE1:Hg19::chr3:52362029..52362031,+#_30f7b30922b07b3050d9176a9b5d85eap@chr3:52362029..52362031, +
1.55e-98FFCP PHASE2:Hg19::chr7:150910973..150910976,-#_30f7b30922b07b3050d9176a9b5d85eap@chr7:150910973..150910976, -
1.55e-98FFCP PHASE1:Hg19::chr7:150910973..150910976,-#_30f7b30922b07b3050d9176a9b5d85eap@chr7:150910973..150910976, -
4.52e-50FFCP PHASE2:Hg19::chr8:22932230..22932233,-#_1bbd5c58093665e40218473c455f369dp5@ENST00000520840, p5@ENST00000523806
4.52e-50FFCP PHASE1:Hg19::chr15:49255230..49255248,-#_1bbd5c58093665e40218473c455f369dp16@SHC4
4.52e-50FFCP PHASE1:Hg19::chr8:22932230..22932233,-#_1bbd5c58093665e40218473c455f369dp5@ENST00000520840, p5@ENST00000523806
4.52e-50FFCP PHASE2:Hg19::chr6:113369869..113369877,+#_1bbd5c58093665e40218473c455f369dp@chr6:113369869..113369877, +
4.52e-50FFCP PHASE2:Hg19::chr10:92617531..92617541,-#_1bbd5c58093665e40218473c455f369dp8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr10:92617531..92617541,-#_1bbd5c58093665e40218473c455f369dp8@HTR7
4.52e-50FFCP PHASE1:Hg19::chr6:113369869..113369877,+#_1bbd5c58093665e40218473c455f369dp@chr6:113369869..113369877, +
4.52e-50FFCP PHASE2:Hg19::chr15:49255230..49255248,-#_1bbd5c58093665e40218473c455f369dp16@SHC4
5.04e-34FFCP PHASE2:Hg19::chr1:44820685..44820695,-#_aba62d1b9ef569dcb04ef444be94a928p10@ERI3
5.04e-34FFCP PHASE2:Hg19::chr6:151770193..151770196,-#_aba62d1b9ef569dcb04ef444be94a928p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE1:Hg19::chr1:44820685..44820695,-#_aba62d1b9ef569dcb04ef444be94a928p10@ERI3
5.04e-34FFCP PHASE1:Hg19::chr6:151770193..151770196,-#_aba62d1b9ef569dcb04ef444be94a928p@chr6:151770193..151770196, -
5.04e-34FFCP PHASE2:Hg19::chr21:47410794..47410799,+#_aba62d1b9ef569dcb04ef444be94a928p@chr21:47410794..47410799, +
5.04e-34FFCP PHASE1:Hg19::chr21:47410794..47410799,+#_aba62d1b9ef569dcb04ef444be94a928p@chr21:47410794..47410799, +
7.05e-34FFCP PHASE2:Hg19::chr15:101459410..101459421,-#_b5550821167fa927230b8bf46d90a4a9p2@ENST00000560068
7.05e-34FFCP PHASE2:Hg19::chr11:65265332..65265342,+#_b5550821167fa927230b8bf46d90a4a9p19@MALAT1
7.05e-34FFCP PHASE1:Hg19::chr15:101459410..101459421,-#_b5550821167fa927230b8bf46d90a4a9p2@ENST00000560068
7.05e-34FFCP PHASE2:Hg19::chr2:25383828..25383855,-#_b5550821167fa927230b8bf46d90a4a9p4@POMC
7.05e-34FFCP PHASE2:Hg19::chr10:43133595..43133606,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:43133595..43133606, -
7.05e-34FFCP PHASE2:Hg19::chr1:9970194..9970195,-#_b5550821167fa927230b8bf46d90a4a9p14@CTNNBIP1
7.05e-34FFCP PHASE1:Hg19::chr2:25383828..25383855,-#_b5550821167fa927230b8bf46d90a4a9p4@POMC
7.05e-34FFCP PHASE1:Hg19::chr10:43133595..43133606,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:43133595..43133606, -
7.05e-34FFCP PHASE2:Hg19::chr10:74020629..74020634,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:74020629..74020634, -
7.05e-34FFCP PHASE1:Hg19::chr1:9970194..9970195,-#_b5550821167fa927230b8bf46d90a4a9p14@CTNNBIP1
7.05e-34FFCP PHASE1:Hg19::chr10:74020629..74020634,-#_b5550821167fa927230b8bf46d90a4a9p@chr10:74020629..74020634, -
7.05e-34FFCP PHASE2:Hg19::chr5:79375654..79375674,+#_b5550821167fa927230b8bf46d90a4a9p@chr5:79375654..79375674, +
7.05e-34FFCP PHASE1:Hg19::chr5:79375654..79375674,+#_b5550821167fa927230b8bf46d90a4a9p@chr5:79375654..79375674, +
7.05e-34FFCP PHASE1:Hg19::chr11:65265332..65265342,+#_b5550821167fa927230b8bf46d90a4a9p19@MALAT1
6.41e-31FFCP PHASE2:Hg19::chr4:111536534..111536575,-#_8b16d2da7d04c381833ab6d4a3d4191fp1@ENST00000503456
6.41e-31FFCP PHASE1:Hg19::chr4:111536534..111536575,-#_8b16d2da7d04c381833ab6d4a3d4191fp1@ENST00000503456
4.55e-29FFCP PHASE2:Hg19::chrX:19688475..19688492,-#_72b8f44f4f9c9883b82a3be157be9b49p26@SH3KBP1
4.55e-29FFCP PHASE1:Hg19::chrX:19688475..19688492,-#_72b8f44f4f9c9883b82a3be157be9b49p26@SH3KBP1
9.18e-26FFCP PHASE2:Hg19::chr4:57522753..57522760,-#_53de05d9a3c9c8f56c37ffadd63fef2cp18@HOPX
9.18e-26FFCP PHASE2:Hg19::chr15:90344775..90344794,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr15:90344775..90344794, +
9.18e-26FFCP PHASE1:Hg19::chr21:47681190..47681194,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47681190..47681194, -
9.18e-26FFCP PHASE1:Hg19::chr16:10590513..10590515,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr16:10590513..10590515, -
9.18e-26FFCP PHASE2:Hg19::chr7:100806199..100806216,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:100806199..100806216, -
9.18e-26FFCP PHASE2:Hg19::chr2:219540880..219540912,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr2:219540880..219540912, +
9.18e-26FFCP PHASE1:Hg19::chr15:90344775..90344794,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr15:90344775..90344794, +
9.18e-26FFCP PHASE1:Hg19::chr7:100806199..100806216,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:100806199..100806216, -
9.18e-26FFCP PHASE2:Hg19::chr21:47397571..47397582,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47397571..47397582, -
9.18e-26FFCP PHASE1:Hg19::chr2:219540880..219540912,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr2:219540880..219540912, +
9.18e-26FFCP PHASE1:Hg19::chr4:57522753..57522760,-#_53de05d9a3c9c8f56c37ffadd63fef2cp18@HOPX
9.18e-26FFCP PHASE1:Hg19::chr21:47397571..47397582,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47397571..47397582, -
9.18e-26FFCP PHASE1:Hg19::chr12:53693440..53693450,-#_53de05d9a3c9c8f56c37ffadd63fef2cp2@CU687581
9.18e-26FFCP PHASE2:Hg19::chr4:73434498..73434509,-#_53de05d9a3c9c8f56c37ffadd63fef2cp6@ADAMTS3
9.18e-26FFCP PHASE2:Hg19::chr10:86153606..86153623,+#_53de05d9a3c9c8f56c37ffadd63fef2cp9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr17:30185971..30185986,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@C17orf79
9.18e-26FFCP PHASE2:Hg19::chr12:53693440..53693450,-#_53de05d9a3c9c8f56c37ffadd63fef2cp2@CU687581
9.18e-26FFCP PHASE2:Hg19::chr1:93646042..93646043,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@TMED5
9.18e-26FFCP PHASE2:Hg19::chr11:34073641..34073656,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr11:34073641..34073656, -
9.18e-26FFCP PHASE1:Hg19::chr10:86153606..86153623,+#_53de05d9a3c9c8f56c37ffadd63fef2cp9@FAM190B
9.18e-26FFCP PHASE2:Hg19::chr20:60758060..60758074,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr20:60758060..60758074, -
9.18e-26FFCP PHASE2:Hg19::chr1:151171326..151171337,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr1:151171326..151171337, -
9.18e-26FFCP PHASE1:Hg19::chr11:34073641..34073656,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr11:34073641..34073656, -
9.18e-26FFCP PHASE1:Hg19::chr17:30185971..30185986,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@C17orf79
9.18e-26FFCP PHASE1:Hg19::chr1:93646042..93646043,-#_53de05d9a3c9c8f56c37ffadd63fef2cp7@TMED5
9.18e-26FFCP PHASE2:Hg19::chr7:6049190..6049209,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:6049190..6049209, +
9.18e-26FFCP PHASE2:Hg19::chr4:120546882..120546885,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr4:120546882..120546885, -
9.18e-26FFCP PHASE2:Hg19::chr1:179335101..179335112,+#_53de05d9a3c9c8f56c37ffadd63fef2cp6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr4:73434498..73434509,-#_53de05d9a3c9c8f56c37ffadd63fef2cp6@ADAMTS3
9.18e-26FFCP PHASE1:Hg19::chr20:60758060..60758074,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr20:60758060..60758074, -
9.18e-26FFCP PHASE2:Hg19::chr3:9956047..9956079,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr3:9956047..9956079, +
9.18e-26FFCP PHASE2:Hg19::chr1:36024782..36024791,+#_53de05d9a3c9c8f56c37ffadd63fef2cp4@AB383919
9.18e-26FFCP PHASE1:Hg19::chr7:6049190..6049209,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr7:6049190..6049209, +
9.18e-26FFCP PHASE1:Hg19::chr4:120546882..120546885,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr4:120546882..120546885, -
9.18e-26FFCP PHASE1:Hg19::chr1:179335101..179335112,+#_53de05d9a3c9c8f56c37ffadd63fef2cp6@AXDND1
9.18e-26FFCP PHASE1:Hg19::chr3:9956047..9956079,+#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr3:9956047..9956079, +
9.18e-26FFCP PHASE1:Hg19::chr1:151171326..151171337,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr1:151171326..151171337, -
9.18e-26FFCP PHASE2:Hg19::chr21:47681190..47681194,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr21:47681190..47681194, -
9.18e-26FFCP PHASE2:Hg19::chr16:10590513..10590515,-#_53de05d9a3c9c8f56c37ffadd63fef2cp@chr16:10590513..10590515, -
9.18e-26FFCP PHASE1:Hg19::chr1:36024782..36024791,+#_53de05d9a3c9c8f56c37ffadd63fef2cp4@AB383919
6.02e-24FFCP PHASE2:Hg19::chr1:145589059..145589070,-#_449cd59297011b978ac9c00cb5d621f6p3@NUDT17
6.02e-24FFCP PHASE1:Hg19::chr1:145589059..145589070,-#_449cd59297011b978ac9c00cb5d621f6p3@NUDT17
3.81e-21FFCP PHASE2:Hg19::chr17:19648416..19648426,-#_c643b3bbedb7ca9a2b69caa0557e7e3ep13@ALDH3A1
3.81e-21FFCP PHASE1:Hg19::chr17:19648416..19648426,-#_c643b3bbedb7ca9a2b69caa0557e7e3ep13@ALDH3A1
4.66e-21FFCP PHASE2:Hg19::chr6:41562324..41562340,+#_a132959ce27ce8b4e0be0ff5504fbf07p16@FOXP4
4.66e-21FFCP PHASE1:Hg19::chr6:41562324..41562340,+#_a132959ce27ce8b4e0be0ff5504fbf07p16@FOXP4
4.66e-21FFCP PHASE2:Hg19::chr4:52917466..52917498,-#_a132959ce27ce8b4e0be0ff5504fbf07p@chr4:52917466..52917498, -
4.66e-21FFCP PHASE1:Hg19::chr4:52917466..52917498,-#_a132959ce27ce8b4e0be0ff5504fbf07p@chr4:52917466..52917498, -
5.7e-21FFCP PHASE1:Hg19::chr7:73118172..73118185,-#_6827444bb6735ba3e4bf22b13bf4646bp3@STX1A
5.7e-21FFCP PHASE2:Hg19::chr8:27686258..27686262,-#_6827444bb6735ba3e4bf22b13bf4646bp@chr8:27686258..27686262, -
5.7e-21FFCP PHASE2:Hg19::chr19:48244695..48244702,+#_6827444bb6735ba3e4bf22b13bf4646bp14@EHD2
5.7e-21FFCP PHASE1:Hg19::chr8:27686258..27686262,-#_6827444bb6735ba3e4bf22b13bf4646bp@chr8:27686258..27686262, -
5.7e-21FFCP PHASE1:Hg19::chr12:58141331..58141342,+#_6827444bb6735ba3e4bf22b13bf4646bp@chr12:58141331..58141342, +
5.7e-21FFCP PHASE2:Hg19::chr12:58141331..58141342,+#_6827444bb6735ba3e4bf22b13bf4646bp@chr12:58141331..58141342, +
5.7e-21FFCP PHASE1:Hg19::chr19:48244695..48244702,+#_6827444bb6735ba3e4bf22b13bf4646bp14@EHD2
5.7e-21FFCP PHASE2:Hg19::chr5:142254452..142254462,+#_6827444bb6735ba3e4bf22b13bf4646bp29@ARHGAP26
5.7e-21FFCP PHASE1:Hg19::chr5:142254452..142254462,+#_6827444bb6735ba3e4bf22b13bf4646bp29@ARHGAP26
5.7e-21FFCP PHASE2:Hg19::chr7:73118172..73118185,-#_6827444bb6735ba3e4bf22b13bf4646bp3@STX1A
6.96e-21FFCP PHASE2:Hg19::chr9:140348438..140348460,-#_3b19ef7bdbfd9a808b1be5d581addf21p@chr9:140348438..140348460, -
6.96e-21FFCP PHASE2:Hg19::chr9:107754068..107754081,-#_3b19ef7bdbfd9a808b1be5d581addf21p3@ENST00000457720
6.96e-21FFCP PHASE1:Hg19::chr17:71283257..71283270,-#_3b19ef7bdbfd9a808b1be5d581addf21p@chr17:71283257..71283270, -
6.96e-21FFCP PHASE2:Hg19::chr17:53803029..53803034,-#_3b19ef7bdbfd9a808b1be5d581addf21p@chr17:53803029..53803034, -
6.96e-21FFCP PHASE2:Hg19::chr19:893600..893603,+#_3b19ef7bdbfd9a808b1be5d581addf21p@chr19:893600..893603, +
6.96e-21FFCP PHASE1:Hg19::chr9:140348438..140348460,-#_3b19ef7bdbfd9a808b1be5d581addf21p@chr9:140348438..140348460, -










Property "Property value" (as page type) with input value "UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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