Coexpression cluster:C197

Full id: C197_tongue_esophagus_tonsil_salivary_cervix_nasal_Gingival

Phase1 CAGE Peaks

Hg19::chr11:93754560..93754567,+	p@chr11:93754560..93754567 +
Hg19::chr12:101962128..101962133,+	p19@MYBPC1
Hg19::chr12:52862701..52862727,-	p@chr12:52862701..52862727 -
Hg19::chr12:52867581..52867598,-	p1@KRT6C
Hg19::chr12:53189894..53189905,-	p1@KRT3
Hg19::chr12:57328187..57328195,-	p1@SDR9C7
Hg19::chr13:103532389..103532398,+	p3@METTL21CP1
Hg19::chr13:103532465..103532483,+	p1@METTL21CP1
Hg19::chr13:103532691..103532727,+	p@chr13:103532691..103532727 +
Hg19::chr13:103555653..103555668,+	p@chr13:103555653..103555668 +
Hg19::chr13:103555674..103555696,+	p@chr13:103555674..103555696 +
Hg19::chr13:103555720..103555725,+	p@chr13:103555720..103555725 +
Hg19::chr16:28890820..28890826,+	p@chr16:28890820..28890826 +
Hg19::chr17:10453082..10453093,-	p7@MYH2
Hg19::chr17:10515218..10515226,+	p@chr17:10515218..10515226 +
Hg19::chr17:39646159..39646164,-	p1@KRT36
Hg19::chr17:39766130..39766139,-	p@chr17:39766130..39766139 -
Hg19::chr17:7991002..7991009,-	p8@ALOX12B
Hg19::chr17:7991027..7991040,-	p1@ALOX12B
Hg19::chr17:7991064..7991073,-	p4@ALOX12B
Hg19::chr17:7991075..7991086,-	p2@ALOX12B
Hg19::chr18:28682160..28682171,-	p11@DSC2
Hg19::chr18:52258473..52258477,+	p1@C18orf26
Hg19::chr19:36018336..36018343,-	p@chr19:36018336..36018343 -
Hg19::chr19:36591495..36591511,+	p@chr19:36591495..36591511 +
Hg19::chr19:42891296..42891305,-	p@chr19:42891296..42891305 -
Hg19::chr19:51563807..51563817,-	p@chr19:51563807..51563817 -
Hg19::chr1:109427881..109427897,+	p5@GPSM2
Hg19::chr1:152130293..152130302,-	p@chr1:152130293..152130302 -
Hg19::chr1:152131703..152131706,-	p1@RPTN
Hg19::chr1:152957997..152958025,+	p4@SPRR1A
Hg19::chr1:153004800..153004809,+	p6@SPRR1B
Hg19::chr1:153004839..153004866,+	p2@SPRR1B
Hg19::chr1:153004879..153004890,+	p4@SPRR1B
Hg19::chr1:153005112..153005146,+	p@chr1:153005112..153005146 +
Hg19::chr1:153005159..153005205,+	p@chr1:153005159..153005205 +
Hg19::chr1:153013588..153013605,-	p1@SPRR2D
Hg19::chr1:153029029..153029042,-	p@chr1:153029029..153029042 -
Hg19::chr1:153029980..153029995,-	p1@SPRR2A
Hg19::chr1:153044083..153044088,-	p1@SPRR2B
Hg19::chr1:153066998..153067008,-	p1@SPRR2E
Hg19::chr1:153085984..153085999,-	p1@SPRR2F p2@SPRR2A
Hg19::chr1:153113940..153113972,-	p1@SPRR2C p2@SPRR2D p3@SPRR2A
Hg19::chr1:153113974..153113991,-	p3@SPRR2C p4@SPRR2D p5@SPRR2A
Hg19::chr1:153114001..153114013,-	p2@SPRR2C p3@SPRR2D p4@SPRR2A
Hg19::chr1:153114023..153114029,-	p4@SPRR2C p5@SPRR2D p6@SPRR2A
Hg19::chr1:153123359..153123372,-	p1@SPRR2G
Hg19::chr1:153388993..153389000,+	p1@S100A7A
Hg19::chr1:153430341..153430348,-	p6@S100A7
Hg19::chr1:153430422..153430443,-	p3@S100A7
Hg19::chr1:153431372..153431378,-	p4@S100A7
Hg19::chr1:153433120..153433129,-	p1@S100A7
Hg19::chr1:159832438..159832449,-	p1@VSIG8
Hg19::chr1:1846607..1846616,+	p6@CALML6
Hg19::chr1:1846804..1846823,+	p3@CALML6
Hg19::chr20:2290823..2290833,+	p@chr20:2290823..2290833 +
Hg19::chr20:2312685..2312717,+	p@chr20:2312685..2312717 +
Hg19::chr20:2321399..2321407,+	p@chr20:2321399..2321407 +
Hg19::chr20:43803535..43803553,+	p1@PI3
Hg19::chr20:43804494..43804505,+	p@chr20:43804494..43804505 +
Hg19::chr20:43804621..43804628,+	p@chr20:43804621..43804628 +
Hg19::chr20:43804675..43804691,+	p@chr20:43804675..43804691 +
Hg19::chr21:31768348..31768356,+	p1@KRTAP13-1
Hg19::chr21:45743612..45743625,+	p@chr21:45743612..45743625 +
Hg19::chr2:106128079..106128106,+	p@chr2:106128079..106128106 +
Hg19::chr2:113816771..113816777,+	p1@IL36RN
Hg19::chr3:133348367..133348368,-	p@chr3:133348367..133348368 -
Hg19::chr3:46027166..46027193,-	p@chr3:46027166..46027193 -
Hg19::chr3:57286665..57286681,+	p@chr3:57286665..57286681 +
Hg19::chr3:57326704..57326721,-	p1@ASB14
Hg19::chr4:68749705..68749725,-	p1@TMPRSS11D
Hg19::chr4:68749745..68749756,-	p2@TMPRSS11D
Hg19::chr5:147715119..147715124,+	p1@SPINK9
Hg19::chr5:150040771..150040781,+	p7@MYOZ3
Hg19::chr6:2744269..2744281,-	p@chr6:2744269..2744281 -
Hg19::chr6:2744361..2744382,-	p@chr6:2744361..2744382 -
Hg19::chr6:2744431..2744440,-	p@chr6:2744431..2744440 -
Hg19::chr6:2751146..2751162,-	p1@MYLK4
Hg19::chr7:141066909..141066949,+	p@chr7:141066909..141066949 +
Hg19::chr7:46064019..46064047,-	p@chr7:46064019..46064047 -
Hg19::chr7:80412875..80412912,-	p@chr7:80412875..80412912 -
Hg19::chr8:143866581..143866589,-	p@chr8:143866581..143866589 -
Hg19::chr8:143866652..143866665,-	p@chr8:143866652..143866665 -
Hg19::chr9:136184568..136184572,+	p1@LCN1P2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030216	keratinocyte differentiation	1.41377271188228e-22
GO:0001533	cornified envelope	2.09843797592739e-21
GO:0008544	epidermis development	3.54818497190057e-18
GO:0007398	ectoderm development	6.47311958840782e-18
GO:0007566	embryo implantation	9.0240676857688e-17
GO:0031424	keratinization	1.15717915921942e-16
GO:0009913	epidermal cell differentiation	9.09423997553288e-16
GO:0048730	epidermis morphogenesis	2.14163868075365e-15
GO:0009888	tissue development	9.8258948593668e-15
GO:0042698	menstrual cycle	9.8258948593668e-15
GO:0048729	tissue morphogenesis	1.51753803813706e-14
GO:0005856	cytoskeleton	7.05958323542508e-13
GO:0048609	reproductive process in a multicellular organism	7.05958323542508e-13
GO:0032504	multicellular organism reproduction	7.05958323542508e-13
GO:0007565	female pregnancy	5.19500409919953e-12
GO:0022414	reproductive process	1.30575350682352e-09
GO:0051704	multi-organism process	2.46426429272213e-09
GO:0048513	organ development	8.42293050941528e-09
GO:0043232	intracellular non-membrane-bound organelle	1.28987918594192e-08
GO:0043228	non-membrane-bound organelle	1.28987918594192e-08
GO:0009653	anatomical structure morphogenesis	5.70036548952603e-08
GO:0048856	anatomical structure development	2.00814308172839e-07
GO:0048731	system development	2.28875902185992e-07
GO:0048869	cellular developmental process	7.19033913179365e-07
GO:0030154	cell differentiation	7.19033913179365e-07
GO:0032501	multicellular organismal process	3.43078017666563e-06
GO:0007275	multicellular organismal development	7.34854023939061e-06
GO:0005882	intermediate filament	9.40971067965266e-06
GO:0045111	intermediate filament cytoskeleton	9.40971067965266e-06
GO:0032502	developmental process	3.74286315267922e-05
GO:0044430	cytoskeletal part	4.87757962062124e-05
GO:0030017	sarcomere	5.39273216063763e-05
GO:0030016	myofibril	7.06316225131419e-05
GO:0044449	contractile fiber part	9.97559417589415e-05
GO:0043292	contractile fiber	0.000116884456891877
GO:0005737	cytoplasm	0.000116884456891877
GO:0032982	myosin filament	0.00041900365286357
GO:0005863	striated muscle thick filament	0.00041900365286357
GO:0005859	muscle myosin complex	0.00101597587724844
GO:0016460	myosin II complex	0.00104641705511306
GO:0018149	peptide cross-linking	0.00104641705511306
GO:0006941	striated muscle contraction	0.00208158898038636
GO:0044424	intracellular part	0.00283298113520072
GO:0050829	defense response to Gram-negative bacterium	0.00746985107196519
GO:0004052	arachidonate 12-lipoxygenase activity	0.00746985107196519
GO:0043229	intracellular organelle	0.00845113269078566
GO:0043226	organelle	0.00845113269078566
GO:0030674	protein binding, bridging	0.0108954268859156
GO:0016459	myosin complex	0.0146609841768646
GO:0007620	copulation	0.0167871400047718
GO:0005622	intracellular	0.0239417025024281
GO:0005509	calcium ion binding	0.0244490687094494
GO:0003012	muscle system process	0.0304615149269455
GO:0006936	muscle contraction	0.0304615149269455
GO:0030280	structural constituent of epidermis	0.0304615149269455
GO:0004867	serine-type endopeptidase inhibitor activity	0.0307654972726924
GO:0007618	mating	0.0346355881358288
GO:0016165	lipoxygenase activity	0.0346355881358288
GO:0051238	sequestering of metal ion	0.0368712827874512
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	0.0383904072748272
GO:0030018	Z disc	0.0383904072748272
GO:0045103	intermediate filament-based process	0.0398109792250047
GO:0000146	microfilament motor activity	0.0398109792250047
GO:0031674	I band	0.0443788883667347

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endo-epithelial cell	1.64e-12	43
epithelial cell	6.87e-08	254
endodermal cell	3.59e-07	59

Uber Anatomy

Ontology term	p-value	n
adult organism	6.11e-10	115
endoderm-derived structure	1.10e-09	169
endoderm	1.10e-09	169
presumptive endoderm	1.10e-09	169
respiratory system	4.58e-09	72
embryo	1.13e-07	612
anatomical system	2.23e-07	625
embryonic structure	2.63e-07	605
developing anatomical structure	2.63e-07	605
anatomical group	3.54e-07	626
germ layer	5.08e-07	604
embryonic tissue	5.08e-07	604
presumptive structure	5.08e-07	604
epiblast (generic)	5.08e-07	604
multi-cellular organism	6.93e-07	659

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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