MCL coexpression mm9:1728

Phase1 CAGE Peaks

	Short description
Mm9::chr19:4214351..4214363,+	p4@Clcf1
Mm9::chr19:4214367..4214375,+	p5@Clcf1
Mm9::chr19:4214383..4214397,+	p2@Clcf1
Mm9::chr1:58782908..58782919,+	p@chr1:58782908..58782919 +
Mm9::chr5:104475807..104475829,+	p4@Nudt9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0046707	IDP metabolic process	0.00468416150769736
GO:0046031	ADP metabolic process	0.00468416150769736
GO:0046032	ADP catabolic process	0.00468416150769736
GO:0046709	IDP catabolic process	0.00468416150769736
GO:0009137	purine nucleoside diphosphate catabolic process	0.00749342659366859
GO:0009181	purine ribonucleoside diphosphate catabolic process	0.00749342659366859
GO:0047631	ADP-ribose diphosphatase activity	0.00749342659366859
GO:0043154	negative regulation of caspase activity	0.00749342659366859
GO:0009179	purine ribonucleoside diphosphate metabolic process	0.00749342659366859
GO:0009135	purine nucleoside diphosphate metabolic process	0.00749342659366859
GO:0009154	purine ribonucleotide catabolic process	0.00780522501817802
GO:0009191	ribonucleoside diphosphate catabolic process	0.00780522501817802
GO:0009185	ribonucleoside diphosphate metabolic process	0.00802779156024886
GO:0009134	nucleoside diphosphate catabolic process	0.00802779156024886
GO:0006195	purine nucleotide catabolic process	0.00819458818282635
GO:0009261	ribonucleotide catabolic process	0.00819458818282635
GO:0017110	nucleoside-diphosphatase activity	0.0110161225902179
GO:0009132	nucleoside diphosphate metabolic process	0.0135231271277465
GO:0030693	caspase activity	0.0137961185645107
GO:0009166	nucleotide catabolic process	0.02058660592066
GO:0007259	JAK-STAT cascade	0.0240556729352763
GO:0043281	regulation of caspase activity	0.0263582653766011
GO:0030183	B cell differentiation	0.0284592064882177
GO:0009150	purine ribonucleotide metabolic process	0.0497921237927268

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
motile cell	3.21e-14	54
lymphoid lineage restricted progenitor cell	6.76e-12	12
connective tissue cell	3.85e-11	46
mesenchymal cell	3.85e-11	46
T cell	6.14e-11	11
pro-T cell	6.14e-11	11
lymphocyte	1.20e-10	13
common lymphoid progenitor	1.20e-10	13
mature alpha-beta T cell	1.59e-10	9
alpha-beta T cell	1.59e-10	9
immature T cell	1.59e-10	9
mature T cell	1.59e-10	9
immature alpha-beta T cell	1.59e-10	9
hematopoietic lineage restricted progenitor cell	6.59e-10	25
CD4-positive, alpha-beta T cell	1.61e-09	8
hematopoietic cell	1.78e-08	32
hematopoietic oligopotent progenitor cell	1.78e-08	32
hematopoietic stem cell	1.78e-08	32
angioblastic mesenchymal cell	1.78e-08	32
hematopoietic multipotent progenitor cell	1.78e-08	32
leukocyte	3.34e-08	17
nongranular leukocyte	3.34e-08	17
nucleate cell	7.08e-08	16
thymocyte	9.92e-08	6
double negative thymocyte	9.92e-08	6
naive T cell	9.92e-08	6
double-positive, alpha-beta thymocyte	9.92e-08	6
CD4-positive, alpha-beta thymocyte	9.92e-08	6
naive thymus-derived CD4-positive, alpha-beta T cell	9.92e-08	6
DN4 thymocyte	9.92e-08	6
DN1 thymic pro-T cell	9.92e-08	6
DN2 thymocyte	9.92e-08	6
DN3 thymocyte	9.92e-08	6
immature single positive thymocyte	9.92e-08	6
early T lineage precursor	9.92e-08	6
mature CD4 single-positive thymocyte	9.92e-08	6
resting double-positive thymocyte	9.92e-08	6
double-positive blast	9.92e-08	6
CD69-positive double-positive thymocyte	9.92e-08	6
CD69-positive, CD4-positive single-positive thymocyte	9.92e-08	6
CD4-positive, CD8-intermediate double-positive thymocyte	9.92e-08	6
CD24-positive, CD4 single-positive thymocyte	9.92e-08	6

Uber Anatomy

Ontology term	p-value	n
connective tissue	3.85e-11	46

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}