MCL coexpression mm9:3252

Phase1 CAGE Peaks

	Short description
Mm9::chr1:17591995..17592015,+	p3@Pi15
Mm9::chr1:17592032..17592035,+	p4@Pi15
Mm9::chr7:28118621..28118659,-	p1@Ltbp4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046879	hormone secretion	0.0411080582264243
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0411080582264243
GO:0019838	growth factor binding	0.0411080582264243
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0437470187188884
GO:0003001	generation of a signal involved in cell-cell signaling	0.0437470187188884

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical space	6.03e-13	57
body cavity precursor	7.98e-11	38
body cavity	8.85e-11	37
body cavity or lining	8.85e-11	37
anatomical cavity	1.37e-10	39
immaterial anatomical entity	6.17e-09	79
reproductive structure	2.82e-08	26
reproductive system	2.82e-08	26
gonad	5.12e-08	18
gonad primordium	5.12e-08	18
reproductive organ	5.38e-08	24
trunk region element	5.68e-08	79
external genitalia	9.28e-08	17
indifferent external genitalia	9.28e-08	17
indifferent gonad	9.28e-08	17
trunk	1.41e-07	90
splanchnic layer of lateral plate mesoderm	3.99e-07	33
multi-cellular organism	4.62e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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