MCL coexpression mm9:70
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0007548 | sex differentiation | 2.03578009326924e-06 |
| GO:0000003 | reproduction | 2.16497557013415e-06 |
| GO:0003006 | reproductive developmental process | 2.16497557013415e-06 |
| GO:0007276 | gamete generation | 1.51226305277813e-05 |
| GO:0019953 | sexual reproduction | 4.49438179970822e-05 |
| GO:0007530 | sex determination | 7.60584778234405e-05 |
| GO:0007281 | germ cell development | 0.000127945363868857 |
| GO:0007283 | spermatogenesis | 0.000187032866444009 |
| GO:0048232 | male gamete generation | 0.000187032866444009 |
| GO:0051327 | M phase of meiotic cell cycle | 0.000187032866444009 |
| GO:0007126 | meiosis | 0.000187032866444009 |
| GO:0051321 | meiotic cell cycle | 0.000187032866444009 |
| GO:0022414 | reproductive process | 0.000192994690355212 |
| GO:0008406 | gonad development | 0.000858847084355522 |
| GO:0048608 | reproductive structure development | 0.000934685543343138 |
| GO:0045137 | development of primary sexual characteristics | 0.00125415041341918 |
| GO:0007127 | meiosis I | 0.00300326324239682 |
| GO:0005844 | polysome | 0.00300326324239682 |
| GO:0007131 | meiotic recombination | 0.00565216074923919 |
| GO:0016591 | DNA-directed RNA polymerase II, holoenzyme | 0.0137993686951777 |
| GO:0000279 | M phase | 0.019738458753447 |
| GO:0008584 | male gonad development | 0.026546625307394 |
| GO:0005669 | transcription factor TFIID complex | 0.026546625307394 |
| GO:0001541 | ovarian follicle development | 0.028737541994697 |
| GO:0022403 | cell cycle phase | 0.0328105114990602 |
| GO:0007049 | cell cycle | 0.0328105114990602 |
| GO:0048477 | oogenesis | 0.0354014626951595 |
| GO:0046546 | development of primary male sexual characteristics | 0.0365871959106186 |
| GO:0045836 | positive regulation of meiosis | 0.0365871959106186 |
| GO:0031143 | pseudopodium | 0.0365871959106186 |
| GO:0006311 | meiotic gene conversion | 0.0365871959106186 |
| GO:0033313 | meiotic cell cycle checkpoint | 0.0365871959106186 |
| GO:0042138 | meiotic DNA double-strand break formation | 0.0365871959106186 |
| GO:0048549 | positive regulation of pinocytosis | 0.0365871959106186 |
| GO:0010032 | meiotic chromosome condensation | 0.0365871959106186 |
| GO:0000400 | four-way junction DNA binding | 0.0365871959106186 |
| GO:0048548 | regulation of pinocytosis | 0.0365871959106186 |
| GO:0033315 | meiotic cell cycle DNA replication checkpoint | 0.0365871959106186 |
| GO:0005026 | transforming growth factor beta receptor activity, type II | 0.0365871959106186 |
| GO:0000332 | template for synthesis of G-rich strand of telomere DNA activity | 0.0365871959106186 |
| GO:0002111 | BRCA2-BRAF35 complex | 0.0365871959106186 |
| GO:0005697 | telomerase holoenzyme complex | 0.0365871959106186 |
| GO:0046661 | male sex differentiation | 0.0385365912660113 |
| GO:0022601 | menstrual cycle phase | 0.0434627625269996 |
| GO:0043283 | biopolymer metabolic process | 0.043735709260655 |
| GO:0022602 | menstrual cycle process | 0.043735709260655 |
| GO:0003729 | mRNA binding | 0.043735709260655 |
| GO:0003700 | transcription factor activity | 0.0453837195440103 |
| GO:0003677 | DNA binding | 0.0487040819257248 |
| GO:0008585 | female gonad development | 0.0487040819257248 |
| GO:0046660 | female sex differentiation | 0.0487040819257248 |
| GO:0007292 | female gamete generation | 0.0487040819257248 |
| GO:0046545 | development of primary female sexual characteristics | 0.0487040819257248 |
| GO:0008494 | translation activator activity | 0.0487040819257248 |
| GO:0045948 | positive regulation of translational initiation | 0.0487040819257248 |
| GO:0003720 | telomerase activity | 0.0487040819257248 |
| GO:0003730 | mRNA 3'-UTR binding | 0.0487040819257248 |
| GO:0001823 | mesonephros development | 0.0487040819257248 |
| GO:0060008 | Sertoli cell differentiation | 0.0487040819257248 |
| GO:0000737 | DNA catabolic process, endonucleolytic | 0.0487040819257248 |
| GO:0009341 | beta-galactosidase complex | 0.0487040819257248 |
| GO:0008247 | 2-acetyl-1-alkylglycerophosphocholine esterase complex | 0.0487040819257248 |
| GO:0000217 | DNA secondary structure binding | 0.0487040819257248 |
| GO:0033327 | Leydig cell differentiation | 0.0487040819257248 |
| GO:0042788 | polysomal ribosome | 0.0487040819257248 |
| GO:0031323 | regulation of cellular metabolic process | 0.0498492540149218 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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