MCL coexpression mm9:1387

Phase1 CAGE Peaks

	Short description
Mm9::chr16:77329743..77329754,+	p14@2810055G20Rik
Mm9::chr16:77329756..77329770,+	p11@2810055G20Rik
Mm9::chr5:13125513..13125537,+	p12@Sema3a
Mm9::chr5:13125558..13125575,+	p14@Sema3a
Mm9::chr5:13125585..13125610,+	p7@Sema3a
Mm9::chr5:13125613..13125635,+	p13@Sema3a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048843	negative regulation of axon extension involved in axon guidance	0.00356105845614419
GO:0048841	regulation of axon extension involved in axon guidance	0.00356105845614419
GO:0048846	axon extension involved in axon guidance	0.00356105845614419
GO:0050919	negative chemotaxis	0.0035610584561442
GO:0007413	axonal fasciculation	0.00445132307018025
GO:0030517	negative regulation of axon extension	0.00445132307018025
GO:0050771	negative regulation of axonogenesis	0.00445132307018025
GO:0002027	regulation of heart rate	0.00445132307018025
GO:0008038	neuron recognition	0.00474807794152559
GO:0030516	regulation of axon extension	0.00498548183860188
GO:0050768	negative regulation of neurogenesis	0.00647465173844399
GO:0048675	axon extension	0.00682536204094304
GO:0050770	regulation of axonogenesis	0.00821782720648661
GO:0008016	regulation of heart contraction	0.00890264614036049
GO:0060047	heart contraction	0.00890264614036049
GO:0008037	cell recognition	0.00890264614036049
GO:0003015	heart process	0.00890264614036049
GO:0050767	regulation of neurogenesis	0.00890264614036049
GO:0007411	axon guidance	0.014806506212389
GO:0008015	blood circulation	0.0154312533099582
GO:0003013	circulatory system process	0.0154312533099582
GO:0042330	taxis	0.0154312533099582
GO:0006935	chemotaxis	0.0154312533099582
GO:0051093	negative regulation of developmental process	0.0154312533099582
GO:0007409	axonogenesis	0.0214982417907964
GO:0048667	neuron morphogenesis during differentiation	0.0214982417907964
GO:0048812	neurite morphogenesis	0.0214982417907964
GO:0000904	cellular morphogenesis during differentiation	0.0235284219423813
GO:0031175	neurite development	0.0239450482395903
GO:0007626	locomotory behavior	0.0239777936047043
GO:0048666	neuron development	0.0250422820464334
GO:0050793	regulation of developmental process	0.0260519539686339
GO:0032990	cell part morphogenesis	0.0260519539686339
GO:0030030	cell projection organization and biogenesis	0.0260519539686339
GO:0048858	cell projection morphogenesis	0.0260519539686339
GO:0016477	cell migration	0.0260519539686339
GO:0030182	neuron differentiation	0.0260519539686339
GO:0051239	regulation of multicellular organismal process	0.0260519539686339
GO:0007610	behavior	0.0274710223759695
GO:0048699	generation of neurons	0.0274710223759695
GO:0051674	localization of cell	0.0274710223759695
GO:0006928	cell motility	0.0274710223759695
GO:0022008	neurogenesis	0.0279915757715521
GO:0042221	response to chemical stimulus	0.0342347210670226
GO:0009605	response to external stimulus	0.0346609689731368
GO:0000902	cell morphogenesis	0.0348529125494964
GO:0032989	cellular structure morphogenesis	0.0348529125494964
GO:0007399	nervous system development	0.0458486276228565

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
surface structure	9.67e-08	22
forelimb	1.58e-07	7
pectoral appendage	1.58e-07	7
pectoral appendage bud	1.58e-07	7
forelimb bud	1.58e-07	7
forelimb/pectoral fin field	1.58e-07	7
sense organ	5.68e-07	12
sensory system	5.68e-07	12
entire sense organ system	5.68e-07	12

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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