MCL coexpression mm9:48
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042613 | MHC class II protein complex | 1.55191553180717e-07 |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 9.06295233755402e-07 |
| GO:0042611 | MHC protein complex | 2.7204030597921e-06 |
| GO:0019882 | antigen processing and presentation | 4.49653694636479e-05 |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 4.58353864721288e-05 |
| GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II | 4.58353864721288e-05 |
| GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 4.58353864721288e-05 |
| GO:0005764 | lysosome | 4.58353864721288e-05 |
| GO:0000323 | lytic vacuole | 4.58353864721288e-05 |
| GO:0005773 | vacuole | 7.32728327283874e-05 |
| GO:0019884 | antigen processing and presentation of exogenous antigen | 8.05484079028954e-05 |
| GO:0048002 | antigen processing and presentation of peptide antigen | 0.000247572829146773 |
| GO:0009897 | external side of plasma membrane | 0.000451747479939822 |
| GO:0043234 | protein complex | 0.000533363449890323 |
| GO:0005771 | multivesicular body | 0.00122866523670196 |
| GO:0009986 | cell surface | 0.00122866523670196 |
| GO:0042605 | peptide antigen binding | 0.00165446978722749 |
| GO:0045582 | positive regulation of T cell differentiation | 0.00187383336418751 |
| GO:0032991 | macromolecular complex | 0.00249064539573452 |
| GO:0045621 | positive regulation of lymphocyte differentiation | 0.00267770237827564 |
| GO:0045580 | regulation of T cell differentiation | 0.00329876706340969 |
| GO:0045619 | regulation of lymphocyte differentiation | 0.00583468301179603 |
| GO:0005770 | late endosome | 0.0077224873319607 |
| GO:0005886 | plasma membrane | 0.00988843316140974 |
| GO:0044459 | plasma membrane part | 0.0114310786246954 |
| GO:0002376 | immune system process | 0.0149747073540423 |
| GO:0050870 | positive regulation of T cell activation | 0.0149747073540423 |
| GO:0046645 | positive regulation of gamma-delta T cell activation | 0.0149747073540423 |
| GO:0045586 | regulation of gamma-delta T cell differentiation | 0.0149747073540423 |
| GO:0008418 | protein N-terminal asparagine amidohydrolase activity | 0.0149747073540423 |
| GO:0045588 | positive regulation of gamma-delta T cell differentiation | 0.0149747073540423 |
| GO:0046643 | regulation of gamma-delta T cell activation | 0.0149747073540423 |
| GO:0030305 | heparanase activity | 0.0149747073540423 |
| GO:0006955 | immune response | 0.0212197630768982 |
| GO:0051251 | positive regulation of lymphocyte activation | 0.0240930797130199 |
| GO:0030217 | T cell differentiation | 0.0240930797130199 |
| GO:0050863 | regulation of T cell activation | 0.0240930797130199 |
| GO:0043366 | beta selection | 0.0240930797130199 |
| GO:0046629 | gamma-delta T cell activation | 0.0240930797130199 |
| GO:0008432 | JUN kinase binding | 0.0240930797130199 |
| GO:0042492 | gamma-delta T cell differentiation | 0.0240930797130199 |
| GO:0043235 | receptor complex | 0.029038299686153 |
| GO:0032632 | interleukin-3 production | 0.029038299686153 |
| GO:0045423 | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.029038299686153 |
| GO:0042223 | interleukin-3 biosynthetic process | 0.029038299686153 |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation | 0.029038299686153 |
| GO:0045399 | regulation of interleukin-3 biosynthetic process | 0.029038299686153 |
| GO:0032604 | granulocyte macrophage colony-stimulating factor production | 0.029038299686153 |
| GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 0.029038299686153 |
| GO:0045401 | positive regulation of interleukin-3 biosynthetic process | 0.029038299686153 |
| GO:0042253 | granulocyte macrophage colony-stimulating factor biosynthetic process | 0.029038299686153 |
| GO:0051249 | regulation of lymphocyte activation | 0.0319209438575822 |
| GO:0050865 | regulation of cell activation | 0.0334504558785296 |
| GO:0043306 | positive regulation of mast cell degranulation | 0.0334504558785296 |
| GO:0046637 | regulation of alpha-beta T cell differentiation | 0.0334504558785296 |
| GO:0043304 | regulation of mast cell degranulation | 0.0334504558785296 |
| GO:0001820 | serotonin secretion | 0.0334504558785296 |
| GO:0008534 | oxidized purine base lesion DNA N-glycosylase activity | 0.0334504558785296 |
| GO:0043302 | positive regulation of leukocyte degranulation | 0.0334504558785296 |
| GO:0030098 | lymphocyte differentiation | 0.0338301193238895 |
| GO:0004716 | receptor signaling protein tyrosine kinase activity | 0.0362601119580879 |
| GO:0004067 | asparaginase activity | 0.0362601119580879 |
| GO:0044440 | endosomal part | 0.0362601119580879 |
| GO:0043300 | regulation of leukocyte degranulation | 0.0362601119580879 |
| GO:0000702 | oxidized base lesion DNA N-glycosylase activity | 0.0362601119580879 |
| GO:0045579 | positive regulation of B cell differentiation | 0.0362601119580879 |
| GO:0010008 | endosome membrane | 0.0362601119580879 |
| GO:0007044 | cell-substrate junction assembly | 0.0362601119580879 |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | 0.0401820961298792 |
| GO:0045921 | positive regulation of exocytosis | 0.0413185711777597 |
| GO:0019815 | B cell receptor complex | 0.0413185711777597 |
| GO:0003823 | antigen binding | 0.0413185711777597 |
| GO:0042110 | T cell activation | 0.0436502832841474 |
| GO:0005765 | lysosomal membrane | 0.0436502832841474 |
| GO:0050853 | B cell receptor signaling pathway | 0.0436502832841474 |
| GO:0043303 | mast cell degranulation | 0.0436502832841474 |
| GO:0002448 | mast cell mediated immunity | 0.0436502832841474 |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | 0.0436502832841474 |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | 0.0436502832841474 |
| GO:0002521 | leukocyte differentiation | 0.0473977546165589 |
| GO:0001958 | endochondral ossification | 0.0477832998932027 |
| GO:0046635 | positive regulation of alpha-beta T cell activation | 0.0477832998932027 |
| GO:0042277 | peptide binding | 0.0477832998932027 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| megakaryocyte progenitor cell | 8.72e-30 | 6 |
| megakaryocyte | 8.72e-30 | 6 |
| megakaryocyte-erythroid progenitor cell | 4.69e-20 | 9 |
| myeloid lineage restricted progenitor cell | 4.85e-14 | 13 |
| lymphocyte of B lineage | 1.20e-12 | 1 |
| B cell | 1.20e-12 | 1 |
| pro-B cell | 1.20e-12 | 1 |
| myeloid cell | 1.71e-11 | 16 |
| hematopoietic lineage restricted progenitor cell | 2.38e-11 | 25 |
| common myeloid progenitor | 9.64e-10 | 19 |
| hematopoietic cell | 6.56e-09 | 32 |
| hematopoietic oligopotent progenitor cell | 6.56e-09 | 32 |
| hematopoietic stem cell | 6.56e-09 | 32 |
| angioblastic mesenchymal cell | 6.56e-09 | 32 |
| hematopoietic multipotent progenitor cell | 6.56e-09 | 32 |
| Ontology term | p-value | n |
|---|---|---|
| lymph node | 4.30e-12 | 1 |
| axillary lymph node | 4.30e-12 | 1 |
| peripheral lymph node | 4.30e-12 | 1 |
| shoulder | 4.30e-12 | 1 |
| bone marrow | 1.71e-11 | 16 |
| hemolymphoid system | 4.01e-11 | 48 |
| immune system | 4.01e-11 | 48 |
| hematopoietic system | 8.21e-09 | 45 |
| blood island | 8.21e-09 | 45 |
| bone element | 1.83e-08 | 22 |
| skeletal element | 1.83e-08 | 22 |
| skeletal system | 1.83e-08 | 22 |
| spleen | 4.75e-08 | 6 |
| cavity lining | 4.75e-08 | 6 |
| serous membrane | 4.75e-08 | 6 |
| gastrointestinal system mesentery | 4.75e-08 | 6 |
| stomach region | 4.75e-08 | 6 |
| mesentery | 4.75e-08 | 6 |
| gastrointestinal system serosa | 4.75e-08 | 6 |
| mesentery of stomach | 4.75e-08 | 6 |
| gut mesentery | 4.75e-08 | 6 |
| dorsal mesentery | 4.75e-08 | 6 |
| dorsal mesogastrium | 4.75e-08 | 6 |
| peritoneal cavity | 4.75e-08 | 6 |
| spleen primordium | 4.75e-08 | 6 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
