MCL coexpression mm9:619

Phase1 CAGE Peaks

	Short description
Mm9::chr14:71018347..71018381,-	p5@Epb4.9
Mm9::chr17:28145497..28145525,-	p1@ENSMUST00000156965
Mm9::chr6:17257254..17257270,+	p9@Cav1
Mm9::chr6:17257272..17257287,+	p10@Cav1
Mm9::chr6:17257659..17257744,+	p1@Cav1
Mm9::chr6:17257746..17257750,+	p14@Cav1
Mm9::chr6:17257878..17257893,+	p7@Cav1
Mm9::chr6:17257899..17257921,+	p4@Cav1
Mm9::chr6:17257943..17257959,+	p8@Cav1
Mm9::chr6:17289478..17289493,+	p@chr6:17289478..17289493 +
Mm9::chr7:16535631..16535670,-	p@chr7:16535631..16535670 -
Mm9::chrX:96085769..96085827,-	p2@Ophn1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0033483	gas homeostasis	0.006299989005677
GO:0052547	regulation of peptidase activity	0.006299989005677
GO:0030857	negative regulation of epithelial cell differentiation	0.006299989005677
GO:0045908	negative regulation of vasodilation	0.006299989005677
GO:0033484	nitric oxide homeostasis	0.006299989005677
GO:0042312	regulation of vasodilation	0.006299989005677
GO:0030036	actin cytoskeleton organization and biogenesis	0.006299989005677
GO:0030029	actin filament-based process	0.006299989005677
GO:0045907	positive regulation of vasoconstriction	0.006299989005677
GO:0048552	regulation of metalloenzyme activity	0.006299989005677
GO:0045019	negative regulation of nitric oxide biosynthetic process	0.006299989005677
GO:0048554	positive regulation of metalloenzyme activity	0.006299989005677
GO:0008047	enzyme activator activity	0.00642131613139922
GO:0046426	negative regulation of JAK-STAT cascade	0.00704309866806752
GO:0001937	negative regulation of endothelial cell proliferation	0.00704309866806752
GO:0060056	mammary gland involution	0.00704309866806752
GO:0003779	actin binding	0.00704309866806752
GO:0043409	negative regulation of MAPKKK cascade	0.0104982558724032
GO:0009892	negative regulation of metabolic process	0.0108361950797176
GO:0001936	regulation of endothelial cell proliferation	0.0108361950797176
GO:0008092	cytoskeletal protein binding	0.0108361950797176
GO:0019217	regulation of fatty acid metabolic process	0.0115011763969493
GO:0030856	regulation of epithelial cell differentiation	0.0115011763969493
GO:0001935	endothelial cell proliferation	0.0116269258240364
GO:0016599	caveolar membrane	0.0116269258240364
GO:0019229	regulation of vasoconstriction	0.0116269258240364
GO:0005901	caveola	0.0117265153474903
GO:0045428	regulation of nitric oxide biosynthetic process	0.0117265153474903
GO:0000188	inactivation of MAPK activity	0.0117265153474903
GO:0019915	sequestering of lipid	0.0125944559437872
GO:0007010	cytoskeleton organization and biogenesis	0.0131029077561029
GO:0016504	protease activator activity	0.013737900740806
GO:0000299	integral to membrane of membrane fraction	0.013737900740806
GO:0016043	cellular component organization and biogenesis	0.013749311394344
GO:0046425	regulation of JAK-STAT cascade	0.0140315153656317
GO:0042311	vasodilation	0.0140692156112715
GO:0042310	vasoconstriction	0.0140692156112715
GO:0046209	nitric oxide metabolic process	0.0140692156112715
GO:0043407	negative regulation of MAP kinase activity	0.0140692156112715
GO:0042632	cholesterol homeostasis	0.0140692156112715
GO:0006809	nitric oxide biosynthetic process	0.0140692156112715
GO:0006940	regulation of smooth muscle contraction	0.0140692156112715
GO:0055088	lipid homeostasis	0.0140692156112715
GO:0051899	membrane depolarization	0.0140692156112715
GO:0055092	sterol homeostasis	0.0140692156112715
GO:0043408	regulation of MAPKKK cascade	0.0140692156112715
GO:0051016	barbed-end actin filament capping	0.0140692156112715
GO:0030835	negative regulation of actin filament depolymerization	0.0140692156112715
GO:0006641	triacylglycerol metabolic process	0.0140692156112715
GO:0051693	actin filament capping	0.0140692156112715
GO:0019216	regulation of lipid metabolic process	0.0140692156112715
GO:0065008	regulation of biological quality	0.0141602239531468
GO:0030834	regulation of actin filament depolymerization	0.0141602239531468
GO:0051260	protein homooligomerization	0.0141602239531468
GO:0030042	actin filament depolymerization	0.0141602239531468
GO:0001666	response to hypoxia	0.0141602239531468
GO:0030879	mammary gland development	0.0145734667951733
GO:0006639	acylglycerol metabolic process	0.0156225056388434
GO:0046486	glycerolipid metabolic process	0.0157301330214369
GO:0006638	neutral lipid metabolic process	0.0157301330214369
GO:0006939	smooth muscle contraction	0.0158307499795965
GO:0006662	glycerol ether metabolic process	0.0158307499795965
GO:0007259	JAK-STAT cascade	0.0159795788235808
GO:0051241	negative regulation of multicellular organismal process	0.0159795788235808
GO:0001570	vasculogenesis	0.0159795788235808
GO:0051259	protein oligomerization	0.0159795788235808
GO:0008064	regulation of actin polymerization and/or depolymerization	0.0159795788235808
GO:0009890	negative regulation of biosynthetic process	0.0159795788235808
GO:0051261	protein depolymerization	0.0159795788235808
GO:0032535	regulation of cellular component size	0.0159795788235808
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	0.0159795788235808
GO:0030832	regulation of actin filament length	0.0159795788235808
GO:0006937	regulation of muscle contraction	0.0159795788235808
GO:0051129	negative regulation of cellular component organization and biogenesis	0.0159795788235808
GO:0045121	lipid raft	0.0159795788235808
GO:0003018	vascular process in circulatory system	0.0159795788235808
GO:0035150	regulation of tube size	0.0159795788235808
GO:0051493	regulation of cytoskeleton organization and biogenesis	0.0159795788235808
GO:0033043	regulation of organelle organization and biogenesis	0.0159795788235808
GO:0050880	regulation of blood vessel size	0.0159795788235808
GO:0048471	perinuclear region of cytoplasm	0.0159795788235808
GO:0048523	negative regulation of cellular process	0.0159795788235808
GO:0030855	epithelial cell differentiation	0.0159795788235808
GO:0006469	negative regulation of protein kinase activity	0.0159795788235808
GO:0033673	negative regulation of kinase activity	0.0159795788235808
GO:0051348	negative regulation of transferase activity	0.0166693735062763
GO:0008154	actin polymerization and/or depolymerization	0.0173431207786081
GO:0048519	negative regulation of biological process	0.0175818613596208
GO:0042391	regulation of membrane potential	0.0177991051732299
GO:0005938	cell cortex	0.0194749469217216
GO:0043086	negative regulation of catalytic activity	0.0194749469217216
GO:0051128	regulation of cellular component organization and biogenesis	0.0221237649373292
GO:0006874	cellular calcium ion homeostasis	0.0239057884286992
GO:0043405	regulation of MAP kinase activity	0.0240510247413231
GO:0055074	calcium ion homeostasis	0.0241931599858816
GO:0006996	organelle organization and biogenesis	0.0249903506627886
GO:0006875	cellular metal ion homeostasis	0.0256294601944308
GO:0055065	metal ion homeostasis	0.0258698153636066
GO:0051248	negative regulation of protein metabolic process	0.0258698153636066
GO:0048732	gland development	0.0278617492606456
GO:0044271	nitrogen compound biosynthetic process	0.0283283464028833
GO:0003012	muscle system process	0.030325157929097
GO:0006936	muscle contraction	0.030325157929097
GO:0045596	negative regulation of cell differentiation	0.0307538950754711
GO:0009968	negative regulation of signal transduction	0.0322439760883674
GO:0007519	skeletal muscle development	0.03277731045783
GO:0008015	blood circulation	0.03277731045783
GO:0003013	circulatory system process	0.03277731045783
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.03277731045783
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.0334994817972183
GO:0006816	calcium ion transport	0.0345952572881161
GO:0030003	cellular cation homeostasis	0.0345952572881161
GO:0051093	negative regulation of developmental process	0.0345952572881161
GO:0055080	cation homeostasis	0.0352516481138001
GO:0005515	protein binding	0.0352516481138001
GO:0051336	regulation of hydrolase activity	0.0353110778694542
GO:0051240	positive regulation of multicellular organismal process	0.0375581357212475
GO:0008285	negative regulation of cell proliferation	0.0375581357212475
GO:0000165	MAPKKK cascade	0.0375581357212475
GO:0048771	tissue remodeling	0.0378576733827624
GO:0014706	striated muscle development	0.0378576733827624
GO:0002009	morphogenesis of an epithelium	0.0378576733827624
GO:0006461	protein complex assembly	0.0381562639468962
GO:0045859	regulation of protein kinase activity	0.0384499058216531
GO:0043549	regulation of kinase activity	0.0395773064087564
GO:0015674	di-, tri-valent inorganic cation transport	0.0395773064087564
GO:0043085	positive regulation of catalytic activity	0.0395773064087564
GO:0051338	regulation of transferase activity	0.0395773064087564
GO:0055082	cellular chemical homeostasis	0.0421181734176855
GO:0006873	cellular ion homeostasis	0.0421181734176855
GO:0035239	tube morphogenesis	0.0423645627375206
GO:0005096	GTPase activator activity	0.0428887853344136
GO:0045595	regulation of cell differentiation	0.0431253665652444
GO:0009889	regulation of biosynthetic process	0.0433582941140103
GO:0006631	fatty acid metabolic process	0.0444132124674194
GO:0007517	muscle development	0.0452719842466176
GO:0050801	ion homeostasis	0.0452719842466176
GO:0010324	membrane invagination	0.0452719842466176
GO:0006897	endocytosis	0.0452719842466176
GO:0048514	blood vessel morphogenesis	0.0462736517263243

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial bud	3.29e-08	17
cardiovascular system	1.53e-07	23
circulatory system	1.53e-07	23
lung	6.07e-07	14
respiratory tube	6.07e-07	14
respiration organ	6.07e-07	14
pair of lungs	6.07e-07	14
lung primordium	6.07e-07	14
lung bud	6.07e-07	14
epithelial fold	9.14e-07	20

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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