MCL coexpression mm9:2571

Phase1 CAGE Peaks

	Short description
Mm9::chr10:62801771..62801790,-	p1@Sirt1
Mm9::chr11:51076447..51076456,+	p3@Clk4
Mm9::chr5:24348806..24348819,+	p@chr5:24348806..24348819 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0017136	NAD-dependent histone deacetylase activity	0.0164356544129732
GO:0016575	histone deacetylation	0.0205366887714151
GO:0006476	protein amino acid deacetylation	0.0205366887714151
GO:0005677	chromatin silencing complex	0.0205366887714151
GO:0001542	ovulation from ovarian follicle	0.0205366887714151
GO:0030728	ovulation	0.0205366887714151
GO:0004407	histone deacetylase activity	0.0205366887714151
GO:0033558	protein deacetylase activity	0.0205366887714151
GO:0006342	chromatin silencing	0.0205366887714151
GO:0031507	heterochromatin formation	0.0205366887714151
GO:0019213	deacetylase activity	0.0205366887714151
GO:0045814	negative regulation of gene expression, epigenetic	0.0205366887714151
GO:0016585	chromatin remodeling complex	0.0243007796075995
GO:0016458	gene silencing	0.0243007796075995
GO:0022601	menstrual cycle phase	0.0243007796075995
GO:0022602	menstrual cycle process	0.0243007796075995
GO:0046777	protein amino acid autophosphorylation	0.0243007796075995
GO:0016570	histone modification	0.0243007796075995
GO:0008585	female gonad development	0.0243007796075995
GO:0016540	protein autoprocessing	0.0243007796075995
GO:0007292	female gamete generation	0.0243007796075995
GO:0046545	development of primary female sexual characteristics	0.0243007796075995
GO:0046660	female sex differentiation	0.0243007796075995
GO:0006338	chromatin remodeling	0.0243007796075995
GO:0016569	covalent chromatin modification	0.0243007796075995
GO:0042698	menstrual cycle	0.0252114286319411
GO:0043687	post-translational protein modification	0.0252114286319411
GO:0040029	regulation of gene expression, epigenetic	0.0252114286319411
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	0.0271688160209374
GO:0008406	gonad development	0.0271936986871097
GO:0048608	reproductive structure development	0.0271936986871097
GO:0018212	peptidyl-tyrosine modification	0.0271936986871097
GO:0018108	peptidyl-tyrosine phosphorylation	0.0271936986871097
GO:0006464	protein modification process	0.0271936986871097
GO:0045137	development of primary sexual characteristics	0.0271936986871097
GO:0043412	biopolymer modification	0.0277475735057699
GO:0016485	protein processing	0.029265450018203
GO:0048609	reproductive process in a multicellular organism	0.0298639425076289
GO:0032504	multicellular organism reproduction	0.0298639425076289
GO:0007548	sex differentiation	0.0299359074312822
GO:0003006	reproductive developmental process	0.0343945123512573
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.0351333917681283
GO:0018193	peptidyl-amino acid modification	0.035394693253886
GO:0007519	skeletal muscle development	0.035394693253886
GO:0031497	chromatin assembly	0.0386037370684783
GO:0014706	striated muscle development	0.0434457251676283
GO:0006333	chromatin assembly or disassembly	0.0456468744106684

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	4.33e-07	9
epithelial cell of alimentary canal	4.33e-07	9

Uber Anatomy

Ontology term	p-value	n
simple columnar epithelium	8.06e-08	11
epithelium of mucosa	4.33e-07	9
gastrointestinal system epithelium	4.33e-07	9
intestinal epithelium	4.33e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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