Coexpression cluster:C626

Full id: C626_penis_skeletal_tongue_diaphragm_salivary_throat_Adipocyte

Phase1 CAGE Peaks

Hg19::chr12:53068552..53068579,-	p@chr12:53068552..53068579 -
Hg19::chr12:53068835..53068874,-	p@chr12:53068835..53068874 -
Hg19::chr12:53068889..53068898,-	p@chr12:53068889..53068898 -
Hg19::chr12:53068923..53068932,-	p@chr12:53068923..53068932 -
Hg19::chr17:10401094..10401106,-	p@chr17:10401094..10401106 -
Hg19::chr17:38974394..38974440,-	p@chr17:38974394..38974440 -
Hg19::chr17:4448859..4448864,-	p@chr17:4448859..4448864 -
Hg19::chr20:33451391..33451397,-	p6@GGT7
Hg19::chr2:178753478..178753487,-	p10@PDE11A
Hg19::chr2:179433518..179433530,-	p@chr2:179433518..179433530 -
Hg19::chr2:179595422..179595432,-	p@chr2:179595422..179595432 -
Hg19::chr2:179640441..179640449,-	p107@TTN
Hg19::chr3:155838361..155838382,+	p10@KCNAB1
Hg19::chrX:135292261..135292285,+	p@chrX:135292261..135292285 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0051393	alpha-actinin binding	0.0168507433336938
GO:0042805	actinin binding	0.0168507433336938
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	0.0168507433336938
GO:0030239	myofibril assembly	0.0168507433336938
GO:0055001	muscle cell development	0.0168507433336938
GO:0055002	striated muscle cell development	0.0168507433336938
GO:0017022	myosin binding	0.0168507433336938
GO:0048628	myoblast maturation	0.0180193423251079
GO:0048627	myoblast development	0.0180193423251079
GO:0030018	Z disc	0.0204093141395362
GO:0051146	striated muscle cell differentiation	0.0204093141395362
GO:0031674	I band	0.0204093141395362
GO:0015459	potassium channel regulator activity	0.0204093141395362
GO:0031032	actomyosin structure organization and biogenesis	0.0221081374747377
GO:0045445	myoblast differentiation	0.025174788347535
GO:0000794	condensed nuclear chromosome	0.025174788347535
GO:0016247	channel regulator activity	0.025174788347535
GO:0006941	striated muscle contraction	0.025174788347535
GO:0048741	skeletal muscle fiber development	0.025174788347535
GO:0008307	structural constituent of muscle	0.025174788347535
GO:0048747	muscle fiber development	0.025174788347535
GO:0046777	protein amino acid autophosphorylation	0.025174788347535
GO:0048469	cell maturation	0.025174788347535
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.025174788347535
GO:0042692	muscle cell differentiation	0.025174788347535
GO:0016540	protein autoprocessing	0.025174788347535
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.025174788347535
GO:0030017	sarcomere	0.025174788347535
GO:0000793	condensed chromosome	0.025174788347535
GO:0030016	myofibril	0.025174788347535
GO:0021700	developmental maturation	0.025174788347535
GO:0044449	contractile fiber part	0.0276034512261386
GO:0043292	contractile fiber	0.0285480848324906
GO:0007519	skeletal muscle development	0.0290047049993703
GO:0014706	striated muscle development	0.036984395187087
GO:0016485	protein processing	0.0393456394331647
GO:0000228	nuclear chromosome	0.0393456394331647
GO:0005737	cytoplasm	0.0469339209353349

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
fat cell	3.67e-10	15

Uber Anatomy

Ontology term	p-value	n
adult organism	7.01e-21	115
organism subdivision	1.21e-07	365
surface structure	7.15e-07	95

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.