MCL coexpression mm9:946

Phase1 CAGE Peaks

	Short description
Mm9::chr13:35055660..35055685,-	p1@Eci3
Mm9::chr13:35055694..35055705,-	p2@Eci3
Mm9::chr2:166885638..166885674,-	p@chr2:166885638..166885674 -
Mm9::chr4:137923796..137923807,-	p@chr4:137923796..137923807 -
Mm9::chr4:94316783..94316818,-	p1@Lrrc19
Mm9::chr4:94316825..94316840,-	p2@Lrrc19
Mm9::chr5:114454790..114454818,+	p3@Dao
Mm9::chr9:107507434..107507453,-	p@chr9:107507434..107507453 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006551	leucine metabolic process	0.00905712736433923
GO:0003884	D-amino-acid oxidase activity	0.00905712736433923
GO:0046087	cytidine metabolic process	0.00905712736433923
GO:0046131	pyrimidine ribonucleoside metabolic process	0.0101884308949003
GO:0004126	cytidine deaminase activity	0.010866766470503
GO:0006213	pyrimidine nucleoside metabolic process	0.0118825956045149
GO:0009119	ribonucleoside metabolic process	0.0118825956045149
GO:0009081	branched chain family amino acid metabolic process	0.0118825956045149
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.0237378594464625
GO:0009116	nucleoside metabolic process	0.0237378594464625
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.0237378594464625
GO:0019239	deaminase activity	0.0237378594464625
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.0239947699080005

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	3.23e-08	9
epithelial cell of alimentary canal	3.23e-08	9

Uber Anatomy

Ontology term	p-value	n
intestine	3.68e-23	31
gastrointestinal system	1.42e-19	47
mucosa	3.46e-13	15
intestinal mucosa	1.19e-11	13
anatomical wall	1.19e-11	13
wall of intestine	1.19e-11	13
gastrointestinal system mucosa	1.19e-11	13
kidney	4.12e-09	14
kidney mesenchyme	4.12e-09	14
upper urinary tract	4.12e-09	14
kidney rudiment	4.12e-09	14
kidney field	4.12e-09	14
renal system	1.43e-08	19
urinary system structure	2.05e-08	18
epithelium of mucosa	3.23e-08	9
gastrointestinal system epithelium	3.23e-08	9
intestinal epithelium	3.23e-08	9
organ component layer	3.35e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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