MCL coexpression mm9:867

Phase1 CAGE Peaks

	Short description
Mm9::chr10:61183340..61183369,+	p2@Aifm2
Mm9::chr13:4149879..4149899,-	p1@Akr1c18
Mm9::chr16:35652352..35652356,-	p@chr16:35652352..35652356 -
Mm9::chr17:74573101..74573114,-	p@chr17:74573101..74573114 -
Mm9::chr18:36446929..36446940,+	p@chr18:36446929..36446940 +
Mm9::chr1:89724864..89724867,+	p@chr1:89724864..89724867 +
Mm9::chr6:139790173..139790179,+	p3@Pik3c2g
Mm9::chr7:107064299..107064302,+	p@chr7:107064299..107064302 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0047006	20-alpha-hydroxysteroid dehydrogenase activity	0.0124180500009131
GO:0008208	C21-steroid hormone catabolic process	0.0124180500009131
GO:0006709	progesterone catabolic process	0.0124180500009131
GO:0007567	parturition	0.0149004353413323
GO:0035005	phosphatidylinositol-4-phosphate 3-kinase activity	0.0149004353413323
GO:0042447	hormone catabolic process	0.0159634401118253
GO:0042448	progesterone metabolic process	0.0159634401118253
GO:0031575	G1/S transition checkpoint	0.0177269539092413
GO:0005662	DNA replication factor A complex	0.0177269539092413
GO:0006706	steroid catabolic process	0.0177269539092413
GO:0046332	SMAD binding	0.0177269539092413
GO:0016303	1-phosphatidylinositol-3-kinase activity	0.0177269539092413
GO:0043601	nuclear replisome	0.0177269539092413
GO:0046854	phosphoinositide phosphorylation	0.0177269539092413
GO:0030894	replisome	0.0177269539092413
GO:0035004	phosphoinositide 3-kinase activity	0.0177269539092413
GO:0005829	cytosol	0.0177269539092413
GO:0005942	phosphoinositide 3-kinase complex	0.0177269539092413
GO:0043596	nuclear replication fork	0.0177269539092413
GO:0016307	phosphatidylinositol phosphate kinase activity	0.0177269539092413
GO:0046834	lipid phosphorylation	0.0177269539092413
GO:0007093	mitotic cell cycle checkpoint	0.0219921147550164
GO:0008207	C21-steroid hormone metabolic process	0.0274994885915881
GO:0003697	single-stranded DNA binding	0.0278947196260274
GO:0044255	cellular lipid metabolic process	0.0278947196260274
GO:0016229	steroid dehydrogenase activity	0.0278947196260274
GO:0003690	double-stranded DNA binding	0.0278947196260274
GO:0001727	lipid kinase activity	0.0278947196260274
GO:0030258	lipid modification	0.0294376102880969
GO:0005657	replication fork	0.0294376102880969
GO:0000075	cell cycle checkpoint	0.0294376102880969
GO:0006629	lipid metabolic process	0.0294376102880969
GO:0007088	regulation of mitosis	0.0294376102880969
GO:0044242	cellular lipid catabolic process	0.0294376102880969
GO:0004428	inositol or phosphatidylinositol kinase activity	0.0294376102880969
GO:0006915	apoptosis	0.0294376102880969
GO:0012501	programmed cell death	0.0295802256395712
GO:0008219	cell death	0.0304413879208736
GO:0016265	death	0.0304413879208736
GO:0005737	cytoplasm	0.0305063617587466
GO:0048522	positive regulation of cellular process	0.0365604791767483
GO:0048015	phosphoinositide-mediated signaling	0.0376593496314086
GO:0030384	phosphoinositide metabolic process	0.0376593496314086
GO:0016491	oxidoreductase activity	0.0376593496314086
GO:0019867	outer membrane	0.0379414103506081
GO:0043566	structure-specific DNA binding	0.0387239938629354
GO:0048518	positive regulation of biological process	0.0421566997893442
GO:0005625	soluble fraction	0.0424979738084686
GO:0006650	glycerophospholipid metabolic process	0.0437507936601084
GO:0050660	FAD binding	0.0437507936601084
GO:0044454	nuclear chromosome part	0.0486768931967854

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adrenal gland	4.71e-52	7
adrenal/interrenal gland	4.71e-52	7
intermediate mesoderm	6.42e-26	14
abdomen element	3.68e-09	49
abdominal segment element	3.68e-09	49
abdominal segment of trunk	3.68e-09	49
abdomen	3.68e-09	49
trunk mesenchyme	9.07e-08	45
mesenchyme	3.20e-07	61
entire embryonic mesenchyme	3.20e-07	61

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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