UBERON:0002062

Name:	endocardial cushion
Definition:	"The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Endocardial_cushion, ZFIN:curator]
Xrefs:	Expandlinks: EHDAA:2586 EHDAA2:0000434 EHDAA2:0004028 EMAPA:16696 FMA:70302 [ 200px-Gray465.png] MA:0000078 TAO:0001317 VHOG:0000932 XAO:0004189 ZFA:0001317
Synonyms:	"atrioventricular cushion" RELATED [Wikipedia:Endocardial_cushion] "cardiac cushion" EXACT [PMID:15797462] "endocardial cushion tissue" EXACT [EHDAA2:0000434] "endocardial cushions" RELATED []
Comments:	GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt
Alt_id:	UBERON:FMA_70302-MA_0000078-ZFA_0001317
Subset:	uberon_slim vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	UBERON:0003104(mesenchyme),UBERON:0004121(ectoderm-derived structure),UBERON:0005291(embryonic tissue),UBERON:0005423(developing anatomical structure),UBERON:0009751(cardiac mesenchyme)
develops_from:	UBERON:0002342(neural crest)
part_of:	UBERON:0000922(embryo),UBERON:0000948(heart),UBERON:0002165(endocardium)

Children

develops from:	UBERON:0000946 (cardial valve),UBERON:0002133 (atrioventricular valve)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

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Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002062 (endocardial cushion), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
5.41e-147	FFCP PHASE2:Hg19::chr7:25815812..25815822,-	p@chr7:25815812..25815822, -
5.41e-147	FFCP PHASE1:Hg19::chr7:25815812..25815822,-	p@chr7:25815812..25815822, -
8.98e-131	FFCP PHASE1:Hg19::chr12:3373147..3373149,-	p@chr12:3373147..3373149, -
8.98e-131	FFCP PHASE2:Hg19::chr12:3373147..3373149,-	p@chr12:3373147..3373149, -
7.78e-118	FFCP PHASE1:Hg19::chr1:20355975..20355980,-	p@chr1:20355975..20355980, -
7.78e-118	FFCP PHASE2:Hg19::chr1:20355975..20355980,-	p@chr1:20355975..20355980, -
5.69e-99	FFCP PHASE2:Hg19::chr1:237331032..237331036,+	p@chr1:237331032..237331036, +
5.69e-99	FFCP PHASE1:Hg19::chr1:237331032..237331036,+	p@chr1:237331032..237331036, +
1.52e-87	FFCP PHASE2:Hg19::chr2:18116344..18116353,+	p@chr2:18116344..18116353, +
1.52e-87	FFCP PHASE2:Hg19::chr1:11907265..11907271,-	p9@NPPA
1.52e-87	FFCP PHASE1:Hg19::chr6:6739548..6739577,-	p@chr6:6739548..6739577, -
1.52e-87	FFCP PHASE1:Hg19::chr1:11907265..11907271,-	p9@NPPA
1.52e-87	FFCP PHASE1:Hg19::chr2:18116344..18116353,+	p@chr2:18116344..18116353, +
1.52e-87	FFCP PHASE2:Hg19::chr6:6739548..6739577,-	p@chr6:6739548..6739577, -
7.21e-85	FFCP PHASE1:Hg19::chrX:112324334..112324339,-	p@chrX:112324334..112324339, -
7.21e-85	FFCP PHASE2:Hg19::chrX:112324334..112324339,-	p@chrX:112324334..112324339, -
1.71e-84	FFCP PHASE1:Hg19::chr2:220491902..220491915,+	p11@SLC4A3
1.71e-84	FFCP PHASE2:Hg19::chr2:220491902..220491915,+	p11@SLC4A3
2.27e-84	FFCP PHASE2:Hg19::chr2:179533457..179533461,-	p@chr2:179533457..179533461, -
2.27e-84	FFCP PHASE1:Hg19::chr2:179533457..179533461,-	p@chr2:179533457..179533461, -
3.03e-84	FFCP PHASE2:Hg19::chr2:179398102..179398109,-	p@chr2:179398102..179398109, -
3.03e-84	FFCP PHASE1:Hg19::chr2:179398102..179398109,-	p@chr2:179398102..179398109, -
7.81e-75	FFCP PHASE2:Hg19::chr5:123739302..123739319,-	p@chr5:123739302..123739319, -
7.81e-75	FFCP PHASE1:Hg19::chr5:123739302..123739319,-	p@chr5:123739302..123739319, -
1.01e-74	FFCP PHASE1:Hg19::chr18:64271475..64271484,-	p6@CDH19
1.01e-74	FFCP PHASE2:Hg19::chr18:64271475..64271484,-	p6@CDH19
1.29e-74	FFCP PHASE1:Hg19::chr7:35286774..35286778,-	p@chr7:35286774..35286778, -
1.29e-74	FFCP PHASE2:Hg19::chr7:35286774..35286778,-	p@chr7:35286774..35286778, -
1.66e-74	FFCP PHASE1:Hg19::chr6:129355052..129355056,+	p@chr6:129355052..129355056, +
1.66e-74	FFCP PHASE2:Hg19::chr6:129355052..129355056,+	p@chr6:129355052..129355056, +
2.75e-74	FFCP PHASE2:Hg19::chr3:16940540..16940554,+	p@chr3:16940540..16940554, +
2.75e-74	FFCP PHASE1:Hg19::chr3:16940540..16940554,+	p@chr3:16940540..16940554, +
3.54e-74	FFCP PHASE1:Hg19::chr1:201328779..201328797,-	p@chr1:201328779..201328797, -
3.54e-74	FFCP PHASE1:Hg19::chr3:131523446..131523459,-	p@chr3:131523446..131523459, -
3.54e-74	FFCP PHASE1:Hg19::chr20:33565465..33565475,+	p9@MYH7B
3.54e-74	FFCP PHASE2:Hg19::chr19:55661803..55661807,-	p@chr19:55661803..55661807, -
3.54e-74	FFCP PHASE1:Hg19::chr19:55661803..55661807,-	p@chr19:55661803..55661807, -
3.54e-74	FFCP PHASE2:Hg19::chr3:131523446..131523459,-	p@chr3:131523446..131523459, -
3.54e-74	FFCP PHASE2:Hg19::chr20:33565465..33565475,+	p9@MYH7B
3.54e-74	FFCP PHASE2:Hg19::chr1:201328779..201328797,-	p@chr1:201328779..201328797, -
5.84e-74	FFCP PHASE1:Hg19::chr6:36812121..36812130,-	p@chr6:36812121..36812130, -
5.84e-74	FFCP PHASE2:Hg19::chr6:36812121..36812130,-	p@chr6:36812121..36812130, -
7.51e-74	FFCP PHASE2:Hg19::chr14:105939326..105939337,+	p16@CRIP2
7.51e-74	FFCP PHASE1:Hg19::chr14:105939326..105939337,+	p16@CRIP2
9.64e-74	FFCP PHASE1:Hg19::chr1:206838422..206838456,+	p@chr1:206838422..206838456, +
9.64e-74	FFCP PHASE2:Hg19::chr1:206838422..206838456,+	p@chr1:206838422..206838456, +
1.24e-73	FFCP PHASE1:Hg19::chr1:231983543..231983554,-	p@chr1:231983543..231983554, -
1.24e-73	FFCP PHASE2:Hg19::chr1:231983543..231983554,-	p@chr1:231983543..231983554, -
1.54e-66	FFCP PHASE2:Hg19::chr1:201328328..201328343,-	p@chr1:201328328..201328343, -
1.54e-66	FFCP PHASE1:Hg19::chr1:201328328..201328343,-	p@chr1:201328328..201328343, -
1.71e-66	FFCP PHASE1:Hg19::chr1:237214095..237214115,+	p@chr1:237214095..237214115, +
1.71e-66	FFCP PHASE1:Hg19::chr11:47367243..47367257,-	p@chr11:47367243..47367257, -
1.71e-66	FFCP PHASE2:Hg19::chr11:47367243..47367257,-	p@chr11:47367243..47367257, -
1.71e-66	FFCP PHASE2:Hg19::chr1:237214095..237214115,+	p@chr1:237214095..237214115, +
2.39e-66	FFCP PHASE2:Hg19::chr15:86272097..86272099,+	p@chr15:86272097..86272099, +
2.39e-66	FFCP PHASE1:Hg19::chr15:86272097..86272099,+	p@chr15:86272097..86272099, +
2.39e-66	FFCP PHASE2:Hg19::chr10:92678409..92678410,-	p@chr10:92678409..92678410, -
2.39e-66	FFCP PHASE1:Hg19::chr5:99390735..99390743,-	p@chr5:99390735..99390743, -
2.39e-66	FFCP PHASE1:Hg19::chr10:92678409..92678410,-	p@chr10:92678409..92678410, -
2.39e-66	FFCP PHASE2:Hg19::chr5:99390735..99390743,-	p@chr5:99390735..99390743, -
2.4e-66	FFCP PHASE1:Hg19::chr12:114886577..114886589,-	p@chr12:114886577..114886589, -
2.4e-66	FFCP PHASE1:Hg19::chr1:237996521..237996532,+	p@chr1:237996521..237996532, +
2.4e-66	FFCP PHASE2:Hg19::chr12:114886577..114886589,-	p@chr12:114886577..114886589, -
2.4e-66	FFCP PHASE2:Hg19::chr2:159976509..159976519,+	p@chr2:159976509..159976519, +
2.4e-66	FFCP PHASE1:Hg19::chr12:4735761..4735787,-	p@chr12:4735761..4735787, -
2.4e-66	FFCP PHASE2:Hg19::chr12:4735761..4735787,-	p@chr12:4735761..4735787, -
2.4e-66	FFCP PHASE1:Hg19::chr2:159976509..159976519,+	p@chr2:159976509..159976519, +
2.4e-66	FFCP PHASE2:Hg19::chr1:237996521..237996532,+	p@chr1:237996521..237996532, +
2.41e-66	FFCP PHASE2:Hg19::chr1:237207955..237207959,+	p@chr1:237207955..237207959, +
2.41e-66	FFCP PHASE1:Hg19::chr1:237207955..237207959,+	p@chr1:237207955..237207959, +
2.41e-66	FFCP PHASE1:Hg19::chr2:40480968..40480972,-	p@chr2:40480968..40480972, -
2.41e-66	FFCP PHASE2:Hg19::chr2:40480968..40480972,-	p@chr2:40480968..40480972, -
3.01e-66	FFCP PHASE1:Hg19::chr4:62999501..62999517,+	p@chr4:62999501..62999517, +
3.01e-66	FFCP PHASE2:Hg19::chr4:62999501..62999517,+	p@chr4:62999501..62999517, +
3.35e-66	FFCP PHASE2:Hg19::chr1:11905830..11905839,-	p@chr1:11905830..11905839, -
3.35e-66	FFCP PHASE2:Hg19::chr7:35253487..35253489,-	p@chr7:35253487..35253489, -
3.35e-66	FFCP PHASE2:Hg19::chr9:38650254..38650266,+	p@chr9:38650254..38650266, +
3.35e-66	FFCP PHASE1:Hg19::chr7:44179972..44179982,-	p2@MYL7
3.35e-66	FFCP PHASE2:Hg19::chr7:44178491..44178498,-	p@chr7:44178491..44178498, -
3.35e-66	FFCP PHASE1:Hg19::chr5:65736120..65736128,-	p@chr5:65736120..65736128, -
3.35e-66	FFCP PHASE1:Hg19::chr1:11905830..11905839,-	p@chr1:11905830..11905839, -
3.35e-66	FFCP PHASE1:Hg19::chr7:35253487..35253489,-	p@chr7:35253487..35253489, -
3.35e-66	FFCP PHASE2:Hg19::chr7:44179972..44179982,-	p2@MYL7
3.35e-66	FFCP PHASE1:Hg19::chr9:38650254..38650266,+	p@chr9:38650254..38650266, +
3.35e-66	FFCP PHASE2:Hg19::chr5:65736120..65736128,-	p@chr5:65736120..65736128, -
3.35e-66	FFCP PHASE1:Hg19::chr7:44178491..44178498,-	p@chr7:44178491..44178498, -
4.68e-66	FFCP PHASE2:Hg19::chr10:112524543..112524547,+	p@chr10:112524543..112524547, +
4.68e-66	FFCP PHASE2:Hg19::chr7:44180643..44180652,-	p3@MYL7
4.68e-66	FFCP PHASE1:Hg19::chr10:112524543..112524547,+	p@chr10:112524543..112524547, +
4.68e-66	FFCP PHASE1:Hg19::chr7:44180643..44180652,-	p3@MYL7
5.88e-66	FFCP PHASE1:Hg19::chr6:36812225..36812238,-	p@chr6:36812225..36812238, -
5.88e-66	FFCP PHASE2:Hg19::chr6:36812225..36812238,-	p@chr6:36812225..36812238, -
6.53e-66	FFCP PHASE2:Hg19::chr4:62999459..62999462,+	p@chr4:62999459..62999462, +
6.53e-66	FFCP PHASE1:Hg19::chr2:168104544..168104551,+	p52@XIRP2
6.53e-66	FFCP PHASE2:Hg19::chr2:168104544..168104551,+	p52@XIRP2
6.53e-66	FFCP PHASE1:Hg19::chr4:62999459..62999462,+	p@chr4:62999459..62999462, +
1.15e-65	FFCP PHASE1:Hg19::chr7:123302841..123302854,+	p@chr7:123302841..123302854, +
1.15e-65	FFCP PHASE1:Hg19::chr10:127569398..127569410,-	p5@DHX32
1.15e-65	FFCP PHASE1:Hg19::chrX:121555838..121555874,+	p@chrX:121555838..121555874, +
1.15e-65	FFCP PHASE2:Hg19::chr7:123302841..123302854,+	p@chr7:123302841..123302854, +

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