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DOID:12603

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Name:acute leukemia
Definition:"A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. Because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, CNS, kidneys, and gonads." [url:http\://www.merck.com/mmpe/sec11/ch142/ch142b.html]

Ontology association<br>Each term has an is_a parent in the Disease Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to DISEASE ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:DOID:1240(leukemia)



Children


is a:FF:10455-106G5 (acute lymphoblastic leukemia (B-ALL) cell line:BALL-1),FF:10594-108D9 ()

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples

Human (Homo sapiens)

Mouse (Mus musculus)

Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with DOID:12603 (acute leukemia), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
5.42e-195FFCP PHASE2:Hg19::chr22:22380255..22380263,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr22:22380255..22380263, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896856..43896865,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896856..43896865, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896828..43896833,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896828..43896833, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896378..43896387,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896378..43896387, -
5.42e-195FFCP PHASE1:Hg19::chr11:69440459..69440517,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr11:69440459..69440517, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896927..43896934,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896927..43896934, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896856..43896865,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896856..43896865, -
5.42e-195FFCP PHASE2:Hg19::chr11:69440459..69440517,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr11:69440459..69440517, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896807..43896814,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896807..43896814, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896378..43896387,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896378..43896387, -
5.42e-195FFCP PHASE1:Hg19::chr2:212793161..212793168,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr2:212793161..212793168, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896964..43896973,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896964..43896973, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896927..43896934,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896927..43896934, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896815..43896826,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896815..43896826, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896807..43896814,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896807..43896814, -
5.42e-195FFCP PHASE2:Hg19::chr2:212793161..212793168,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr2:212793161..212793168, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896964..43896973,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896964..43896973, -
5.42e-195FFCP PHASE1:Hg19::chr22:22380255..22380263,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr22:22380255..22380263, -
5.42e-195FFCP PHASE1:Hg19::chr21:43896828..43896833,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896828..43896833, -
5.42e-195FFCP PHASE2:Hg19::chr21:43896815..43896826,-#_ef8f13c670653ab59ed8da08f7e0251bp@chr21:43896815..43896826, -
9.37e-99FFCP PHASE1:Hg19::chr1:206290131..206290135,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr1:206290131..206290135, -
9.37e-99FFCP PHASE1:Hg19::chr22:23246848..23246854,+#_5cf8bc10124c2a2f67bd010a43d893e0p@chr22:23246848..23246854, +
9.37e-99FFCP PHASE2:Hg19::chr1:206290131..206290135,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr1:206290131..206290135, -
9.37e-99FFCP PHASE1:Hg19::chr22:23247044..23247061,+#_5cf8bc10124c2a2f67bd010a43d893e0p1@IGLJ3
9.37e-99FFCP PHASE2:Hg19::chr22:23246848..23246854,+#_5cf8bc10124c2a2f67bd010a43d893e0p@chr22:23246848..23246854, +
9.37e-99FFCP PHASE1:Hg19::chr14:106241968..106241975,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr14:106241968..106241975, -
9.37e-99FFCP PHASE1:Hg19::chr1:206290083..206290090,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr1:206290083..206290090, -
9.37e-99FFCP PHASE2:Hg19::chr22:23247044..23247061,+#_5cf8bc10124c2a2f67bd010a43d893e0p1@IGLJ3
9.37e-99FFCP PHASE2:Hg19::chr14:106241968..106241975,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr14:106241968..106241975, -
9.37e-99FFCP PHASE2:Hg19::chr1:206290083..206290090,-#_5cf8bc10124c2a2f67bd010a43d893e0p@chr1:206290083..206290090, -
2.55e-98FFCP PHASE2:Hg19::chr6:130881420..130881455,-#_c1fbbffe2785333f56011f69ffa75d16p@chr6:130881420..130881455, -
2.55e-98FFCP PHASE1:Hg19::chr13:80975502..80975505,+#_c1fbbffe2785333f56011f69ffa75d16p@chr13:80975502..80975505, +
2.55e-98FFCP PHASE2:Hg19::chr14:106589870..106589873,-#_c1fbbffe2785333f56011f69ffa75d16p@chr14:106589870..106589873, -
2.55e-98FFCP PHASE1:Hg19::chr5:26877541..26877549,+#_c1fbbffe2785333f56011f69ffa75d16p@chr5:26877541..26877549, +
2.55e-98FFCP PHASE1:Hg19::chr1:206290165..206290174,-#_c1fbbffe2785333f56011f69ffa75d16p@chr1:206290165..206290174, -
2.55e-98FFCP PHASE2:Hg19::chr5:26877541..26877549,+#_c1fbbffe2785333f56011f69ffa75d16p@chr5:26877541..26877549, +
2.55e-98FFCP PHASE2:Hg19::chr13:80975502..80975505,+#_c1fbbffe2785333f56011f69ffa75d16p@chr13:80975502..80975505, +
2.55e-98FFCP PHASE1:Hg19::chr22:49818414..49818424,+#_c1fbbffe2785333f56011f69ffa75d16p@chr22:49818414..49818424, +
2.55e-98FFCP PHASE1:Hg19::chr6:130878898..130878925,+#_c1fbbffe2785333f56011f69ffa75d16p@chr6:130878898..130878925, +
2.55e-98FFCP PHASE1:Hg19::chr12:11905335..11905342,+#_c1fbbffe2785333f56011f69ffa75d16p28@ETV6
2.55e-98FFCP PHASE2:Hg19::chr1:206290165..206290174,-#_c1fbbffe2785333f56011f69ffa75d16p@chr1:206290165..206290174, -
2.55e-98FFCP PHASE1:Hg19::chr6:130881420..130881455,-#_c1fbbffe2785333f56011f69ffa75d16p@chr6:130881420..130881455, -
2.55e-98FFCP PHASE2:Hg19::chr6:130878898..130878925,+#_c1fbbffe2785333f56011f69ffa75d16p@chr6:130878898..130878925, +
2.55e-98FFCP PHASE2:Hg19::chr22:49818414..49818424,+#_c1fbbffe2785333f56011f69ffa75d16p@chr22:49818414..49818424, +
2.55e-98FFCP PHASE2:Hg19::chr12:11905335..11905342,+#_c1fbbffe2785333f56011f69ffa75d16p28@ETV6
2.55e-98FFCP PHASE1:Hg19::chr14:106589870..106589873,-#_c1fbbffe2785333f56011f69ffa75d16p@chr14:106589870..106589873, -
1.23e-66FFCP PHASE2:Hg19::chr1:105475811..105475815,+#_272399a027eea1340412923700643751p@chr1:105475811..105475815, +
1.23e-66FFCP PHASE1:Hg19::chrX:139903518..139903525,-#_272399a027eea1340412923700643751p@chrX:139903518..139903525, -
1.23e-66FFCP PHASE1:Hg19::chr2:111806761..111806769,+#_272399a027eea1340412923700643751p@chr2:111806761..111806769, +
1.23e-66FFCP PHASE1:Hg19::chr4:144312629..144312638,+#_272399a027eea1340412923700643751p30@GAB1
1.23e-66FFCP PHASE1:Hg19::chr19:1611369..1611372,-#_272399a027eea1340412923700643751p13@TCF3
1.23e-66FFCP PHASE2:Hg19::chrX:139903518..139903525,-#_272399a027eea1340412923700643751p@chrX:139903518..139903525, -
1.23e-66FFCP PHASE2:Hg19::chr4:144312629..144312638,+#_272399a027eea1340412923700643751p30@GAB1
1.23e-66FFCP PHASE2:Hg19::chr2:111806761..111806769,+#_272399a027eea1340412923700643751p@chr2:111806761..111806769, +
1.23e-66FFCP PHASE2:Hg19::chr19:1611369..1611372,-#_272399a027eea1340412923700643751p13@TCF3
1.23e-66FFCP PHASE1:Hg19::chr1:105475811..105475815,+#_272399a027eea1340412923700643751p@chr1:105475811..105475815, +
2.39e-66FFCP PHASE1:Hg19::chr5:26877504..26877517,+#_48711153e9bee43f23ef1587266d735ep@chr5:26877504..26877517, +
2.39e-66FFCP PHASE1:Hg19::chr5:157603447..157603458,-#_48711153e9bee43f23ef1587266d735ep1@ENST00000522769
2.39e-66FFCP PHASE2:Hg19::chr22:49819110..49819121,-#_48711153e9bee43f23ef1587266d735ep5@C22orf34
2.39e-66FFCP PHASE2:Hg19::chr5:26877504..26877517,+#_48711153e9bee43f23ef1587266d735ep@chr5:26877504..26877517, +
2.39e-66FFCP PHASE2:Hg19::chr5:157603447..157603458,-#_48711153e9bee43f23ef1587266d735ep1@ENST00000522769
2.39e-66FFCP PHASE1:Hg19::chr18:12060071..12060081,+#_48711153e9bee43f23ef1587266d735ep@chr18:12060071..12060081, +
2.39e-66FFCP PHASE1:Hg19::chr22:49819110..49819121,-#_48711153e9bee43f23ef1587266d735ep5@C22orf34
2.39e-66FFCP PHASE2:Hg19::chr18:12060071..12060081,+#_48711153e9bee43f23ef1587266d735ep@chr18:12060071..12060081, +
4.66e-66FFCP PHASE2:Hg19::chr14:87524571..87524574,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr14:87524571..87524574, +
4.66e-66FFCP PHASE2:Hg19::chr5:26877490..26877500,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr5:26877490..26877500, +
4.66e-66FFCP PHASE2:Hg19::chr6:159536146..159536155,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr6:159536146..159536155, +
4.66e-66FFCP PHASE1:Hg19::chr1:207105167..207105184,-#_78fc3db5875c8ac6940ea026b8bc2214p5@PIGR
4.66e-66FFCP PHASE1:Hg19::chr6:24522856..24522861,+#_78fc3db5875c8ac6940ea026b8bc2214p21@ALDH5A1
4.66e-66FFCP PHASE2:Hg19::chr13:61236926..61236943,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr13:61236926..61236943, +
4.66e-66FFCP PHASE2:Hg19::chr1:207105167..207105184,-#_78fc3db5875c8ac6940ea026b8bc2214p5@PIGR
4.66e-66FFCP PHASE2:Hg19::chr6:24522856..24522861,+#_78fc3db5875c8ac6940ea026b8bc2214p21@ALDH5A1
4.66e-66FFCP PHASE1:Hg19::chr12:11905315..11905321,+#_78fc3db5875c8ac6940ea026b8bc2214p30@ETV6
4.66e-66FFCP PHASE1:Hg19::chr5:64369069..64369083,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr5:64369069..64369083, +
4.66e-66FFCP PHASE2:Hg19::chr12:11905315..11905321,+#_78fc3db5875c8ac6940ea026b8bc2214p30@ETV6
4.66e-66FFCP PHASE2:Hg19::chr5:64369069..64369083,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr5:64369069..64369083, +
4.66e-66FFCP PHASE1:Hg19::chr5:26877490..26877500,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr5:26877490..26877500, +
4.66e-66FFCP PHASE1:Hg19::chr6:159536146..159536155,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr6:159536146..159536155, +
4.66e-66FFCP PHASE1:Hg19::chr14:87524571..87524574,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr14:87524571..87524574, +
4.66e-66FFCP PHASE1:Hg19::chr13:61236926..61236943,+#_78fc3db5875c8ac6940ea026b8bc2214p@chr13:61236926..61236943, +
1.46e-50FFCP PHASE2:Hg19::chr1:157522241..157522244,-#_10d2421ea655183e7506a503669fe107p2@FCRL5
1.46e-50FFCP PHASE1:Hg19::chr5:114607144..114607156,-#_10d2421ea655183e7506a503669fe107p9@CCDC112
1.46e-50FFCP PHASE1:Hg19::chr14:106240433..106240439,-#_10d2421ea655183e7506a503669fe107p@chr14:106240433..106240439, -
1.46e-50FFCP PHASE2:Hg19::chr5:114607144..114607156,-#_10d2421ea655183e7506a503669fe107p9@CCDC112
1.46e-50FFCP PHASE1:Hg19::chr22:22550534..22550548,-#_10d2421ea655183e7506a503669fe107p@chr22:22550534..22550548, -
1.46e-50FFCP PHASE1:Hg19::chr12:25261170..25261174,+#_10d2421ea655183e7506a503669fe107p@chr12:25261170..25261174, +
1.46e-50FFCP PHASE2:Hg19::chr14:106240433..106240439,-#_10d2421ea655183e7506a503669fe107p@chr14:106240433..106240439, -
1.46e-50FFCP PHASE1:Hg19::chr1:167301096..167301102,+#_10d2421ea655183e7506a503669fe107p13@POU2F1
1.46e-50FFCP PHASE1:Hg19::chr1:157522241..157522244,-#_10d2421ea655183e7506a503669fe107p2@FCRL5
1.46e-50FFCP PHASE2:Hg19::chr12:25261170..25261174,+#_10d2421ea655183e7506a503669fe107p@chr12:25261170..25261174, +
1.46e-50FFCP PHASE2:Hg19::chr22:22550534..22550548,-#_10d2421ea655183e7506a503669fe107p@chr22:22550534..22550548, -
1.46e-50FFCP PHASE2:Hg19::chr1:167301096..167301102,+#_10d2421ea655183e7506a503669fe107p13@POU2F1
2.42e-50FFCP PHASE1:Hg19::chr12:125634248..125634257,-#_2a1cd08ff8d825092689369be3259b1fp@chr12:125634248..125634257, -
2.42e-50FFCP PHASE1:Hg19::chr18:43246002..43246009,+#_2a1cd08ff8d825092689369be3259b1fp2@X96969
2.42e-50FFCP PHASE1:Hg19::chr12:125634292..125634301,-#_2a1cd08ff8d825092689369be3259b1fp@chr12:125634292..125634301, -
2.42e-50FFCP PHASE2:Hg19::chr12:125634248..125634257,-#_2a1cd08ff8d825092689369be3259b1fp@chr12:125634248..125634257, -
2.42e-50FFCP PHASE1:Hg19::chr10:98045175..98045180,-#_2a1cd08ff8d825092689369be3259b1fp@chr10:98045175..98045180, -
2.42e-50FFCP PHASE1:Hg19::chr1:206290138..206290146,-#_2a1cd08ff8d825092689369be3259b1fp@chr1:206290138..206290146, -
2.42e-50FFCP PHASE2:Hg19::chr18:43246002..43246009,+#_2a1cd08ff8d825092689369be3259b1fp2@X96969
2.42e-50FFCP PHASE2:Hg19::chr10:98045175..98045180,-#_2a1cd08ff8d825092689369be3259b1fp@chr10:98045175..98045180, -

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