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MCL coexpression mm9:1288

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Phase1 CAGE Peaks

 Short description
Mm9::chr11:48890054..48890079,+p4@Ifi47
Mm9::chr11:83037063..83037103,+p1@AI662270
Mm9::chr11:83037941..83037993,+p@chr11:83037941..83037993
+
Mm9::chr5:138041854..138041873,-p3@Mospd3
Mm9::chr6:124270545..124270555,+p@chr6:124270545..124270555
+
Mm9::chr7:134280870..134280915,-p@chr7:134280870..134280915
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002526acute inflammatory response0.00641720429616201
GO:0006952defense response0.00641720429616201
GO:0001808negative regulation of type IV hypersensitivity0.00641720429616201
GO:0002710negative regulation of T cell mediated immunity0.00641720429616201
GO:0001807regulation of type IV hypersensitivity0.00641720429616201
GO:0001806type IV hypersensitivity0.00641720429616201
GO:0008367bacterial binding0.00641720429616201
GO:0002704negative regulation of leukocyte mediated immunity0.00641720429616201
GO:0002865negative regulation of acute inflammatory response to antigenic stimulus0.00641720429616201
GO:0050688regulation of defense response to virus0.00641720429616201
GO:0002862negative regulation of inflammatory response to antigenic stimulus0.00641720429616201
GO:0002884negative regulation of hypersensitivity0.00641720429616201
GO:0002674negative regulation of acute inflammatory response0.00641720429616201
GO:0002707negative regulation of lymphocyte mediated immunity0.00641720429616201
GO:0002698negative regulation of immune effector process0.00842188844134902
GO:0001562response to protozoan0.00842188844134902
GO:0006954inflammatory response0.00921059221611825
GO:0002709regulation of T cell mediated immunity0.00945537829564138
GO:0042535positive regulation of tumor necrosis factor biosynthetic process0.00945537829564138
GO:0031254trailing edge0.00976290341835422
GO:0002820negative regulation of adaptive immune response0.00976290341835422
GO:0001931uropod0.00976290341835422
GO:0002823negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.00976290341835422
GO:0042534regulation of tumor necrosis factor biosynthetic process0.00997903662538861
GO:0050777negative regulation of immune response0.00997903662538861
GO:0002683negative regulation of immune system process0.00997903662538861
GO:0042533tumor necrosis factor biosynthetic process0.00997903662538861
GO:0009611response to wounding0.0106723683662787
GO:0031294lymphocyte costimulation0.0108844324370671
GO:0045060negative thymic T cell selection0.0108844324370671
GO:0002456T cell mediated immunity0.0108844324370671
GO:0043383negative T cell selection0.0108844324370671
GO:0031295T cell costimulation0.0108844324370671
GO:0051607defense response to virus0.0118838630386888
GO:0031348negative regulation of defense response0.0131366414680846
GO:0050728negative regulation of inflammatory response0.0131366414680846
GO:0002883regulation of hypersensitivity0.0131366414680846
GO:0002673regulation of acute inflammatory response0.0131366414680846
GO:0002438acute inflammatory response to antigenic stimulus0.0131366414680846
GO:0002864regulation of acute inflammatory response to antigenic stimulus0.0131366414680846
GO:0002524hypersensitivity0.0131366414680846
GO:0007162negative regulation of cell adhesion0.0136579578557068
GO:0042130negative regulation of T cell proliferation0.0136579578557068
GO:0002861regulation of inflammatory response to antigenic stimulus0.0136579578557068
GO:0002437inflammatory response to antigenic stimulus0.0136579578557068
GO:0045061thymic T cell selection0.0136579578557068
GO:0032640tumor necrosis factor production0.0142575234513148
GO:0009605response to external stimulus0.0142575234513148
GO:0045058T cell selection0.0149550275327956
GO:0002703regulation of leukocyte mediated immunity0.0149550275327956
GO:0002706regulation of lymphocyte mediated immunity0.0149550275327956
GO:0050868negative regulation of T cell activation0.0152195793365695
GO:0008624induction of apoptosis by extracellular signals0.0152195793365695
GO:0002697regulation of immune effector process0.0152195793365695
GO:0050672negative regulation of lymphocyte proliferation0.0152195793365695
GO:0032945negative regulation of mononuclear cell proliferation0.0152195793365695
GO:0002819regulation of adaptive immune response0.0170107971074537
GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.0.0170107971074537
GO:0033077T cell differentiation in the thymus0.0186814953110302
GO:0051250negative regulation of lymphocyte activation0.0186814953110302
GO:0005044scavenger receptor activity0.0191086800642614
GO:0042102positive regulation of T cell proliferation0.0192120934192978
GO:0006953acute-phase response0.0192120934192978
GO:0031347regulation of defense response0.0196940090962517
GO:0051241negative regulation of multicellular organismal process0.0196940090962517
GO:0050727regulation of inflammatory response0.0196940090962517
GO:0042108positive regulation of cytokine biosynthetic process0.0214016935035867
GO:0032946positive regulation of mononuclear cell proliferation0.0233713371432971
GO:0050671positive regulation of lymphocyte proliferation0.0233713371432971
GO:0045727positive regulation of translation0.0255887624298976
GO:0042129regulation of T cell proliferation0.0260145877960401
GO:0006950response to stress0.0260145877960401
GO:0050870positive regulation of T cell activation0.0260145877960401
GO:0031328positive regulation of cellular biosynthetic process0.0260145877960401
GO:0048583regulation of response to stimulus0.0262624911738521
GO:0030155regulation of cell adhesion0.0265037740782453
GO:0009615response to virus0.028475497681558
GO:0042035regulation of cytokine biosynthetic process0.0286817510176231
GO:0050670regulation of lymphocyte proliferation0.0292694109876339
GO:0032944regulation of mononuclear cell proliferation0.0292694109876339
GO:0009891positive regulation of biosynthetic process0.0292694109876339
GO:0042098T cell proliferation0.0299985697471543
GO:0042089cytokine biosynthetic process0.0317079984251362
GO:0051251positive regulation of lymphocyte activation0.0317079984251362
GO:0042107cytokine metabolic process0.0317079984251362
GO:0030217T cell differentiation0.0317079984251362
GO:0005604basement membrane0.0318547476222013
GO:0050863regulation of T cell activation0.0319980782613735
GO:0051247positive regulation of protein metabolic process0.0356326930955626
GO:0032943mononuclear cell proliferation0.0363131132961418
GO:0046651lymphocyte proliferation0.0363131132961418
GO:0051249regulation of lymphocyte activation0.0402570512925066
GO:0050865regulation of cell activation0.0412534276662173
GO:0042742defense response to bacterium0.041285753466503
GO:0002250adaptive immune response0.041348156133183
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.041348156133183
GO:0030098lymphocyte differentiation0.0414364786680503
GO:0002449lymphocyte mediated immunity0.0414364786680503
GO:0044420extracellular matrix part0.0414364786680503
GO:0002443leukocyte mediated immunity0.0436811401562264
GO:0001816cytokine production0.0436811401562264
GO:0050776regulation of immune response0.0483643187311602
GO:0009617response to bacterium0.0483643187311602
GO:0002682regulation of immune system process0.0483643187311602
GO:0042110T cell activation0.0495310418912448
GO:0008285negative regulation of cell proliferation0.0495310418912448



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.36e-1348
immune system1.36e-1348
hematopoietic system3.80e-1345
blood island3.80e-1345
foregut2.71e-0880
hemopoietic organ3.45e-0829
immune organ3.45e-0829
lateral plate mesoderm3.11e-0787
mixed endoderm/mesoderm-derived structure4.57e-0735
connective tissue5.67e-0746


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.135108
MA0004.10.536396
MA0006.10.359699
MA0007.10.52077
MA0009.10.987341
MA0014.10.304529
MA0017.10.387481
MA0019.10.800946
MA0024.10.942716
MA0025.11.22395
MA0027.12.64231
MA0028.10.370592
MA0029.10.920529
MA0030.10.927235
MA0031.10.890871
MA0038.10.686534
MA0040.11.00009
MA0041.12.01886
MA0042.10.443591
MA0043.11.08567
MA0046.11.02391
MA0048.10.161427
MA0050.11.41229
MA0051.11.66123
MA0052.11.00829
MA0055.10.212634
MA0056.10
MA0057.10.149949
MA0058.10.436487
MA0059.10.449345
MA0060.10.757042
MA0061.10.307097
MA0063.10
MA0066.10.675169
MA0067.11.33603
MA0068.10.153907
MA0069.11.00864
MA0070.10.998765
MA0071.10.575909
MA0072.10.990133
MA0073.10.0198269
MA0074.10.638014
MA0076.11.04996
MA0077.10.968053
MA0078.10.729877
MA0081.10.473489
MA0083.11.08487
MA0084.11.66561
MA0087.11.04109
MA0088.10.358337
MA0089.10
MA0090.10.500693
MA0091.11.3559
MA0092.10.501022
MA0093.10.379257
MA0095.10
MA0098.10
MA0100.10.626021
MA0101.10.458688
MA0103.10.398766
MA0105.10.199622
MA0106.10.737893
MA0107.10.392331
MA0108.20.824407
MA0109.10
MA0111.10.515457
MA0113.10.708789
MA0114.10.822296
MA0115.11.08851
MA0116.10.359483
MA0117.11.05576
MA0119.10.459301
MA0122.11.07591
MA0124.11.28237
MA0125.11.20757
MA0130.10
MA0131.10.796279
MA0132.10
MA0133.10
MA0135.11.1226
MA0136.11.58388
MA0139.10.243463
MA0140.10.625902
MA0141.10.419361
MA0142.10.876028
MA0143.10.725672
MA0144.10.307873
MA0145.10.379391
MA0146.10.635245
MA0147.10.320675
MA0148.10.553294
MA0149.10.464445
MA0062.20.591842
MA0035.20.630778
MA0039.20.0823004
MA0138.20.788113
MA0002.20.689262
MA0137.20.416331
MA0104.20.261255
MA0047.20.685741
MA0112.20.76177
MA0065.20.380324
MA0150.10.520653
MA0151.10
MA0152.10.685852
MA0153.11.13945
MA0154.10.159217
MA0155.10.414701
MA0156.11.04798
MA0157.10.843181
MA0158.10
MA0159.11.58527
MA0160.10.556423
MA0161.10
MA0162.10.0465447
MA0163.10.0423021
MA0164.10.658997
MA0080.21.80146
MA0018.20.669032
MA0099.20.781628
MA0079.20.000341844
MA0102.21.7182
MA0258.10.290587
MA0259.10.309517
MA0442.10
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