MCL coexpression mm9:156
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0007049 | cell cycle | 1.44782132470443e-24 |
| GO:0022403 | cell cycle phase | 9.77219291633224e-18 |
| GO:0022402 | cell cycle process | 1.1758897859158e-17 |
| GO:0000279 | M phase | 1.1758897859158e-17 |
| GO:0000278 | mitotic cell cycle | 2.45226822637973e-13 |
| GO:0051301 | cell division | 3.75670463651151e-13 |
| GO:0000775 | chromosome, pericentric region | 9.46731588926466e-12 |
| GO:0005694 | chromosome | 8.60132120126306e-11 |
| GO:0007067 | mitosis | 1.04544677580719e-10 |
| GO:0000087 | M phase of mitotic cell cycle | 1.04544677580719e-10 |
| GO:0044427 | chromosomal part | 2.62217631071725e-09 |
| GO:0043232 | intracellular non-membrane-bound organelle | 1.265689423572e-08 |
| GO:0043228 | non-membrane-bound organelle | 1.265689423572e-08 |
| GO:0051327 | M phase of meiotic cell cycle | 6.18200776936742e-08 |
| GO:0007126 | meiosis | 6.18200776936742e-08 |
| GO:0051321 | meiotic cell cycle | 6.38670679162396e-08 |
| GO:0000793 | condensed chromosome | 9.56985388378011e-08 |
| GO:0030496 | midbody | 6.78530907114803e-07 |
| GO:0004674 | protein serine/threonine kinase activity | 7.30829495754949e-07 |
| GO:0005634 | nucleus | 3.62053258431639e-06 |
| GO:0044446 | intracellular organelle part | 3.7693393557102e-06 |
| GO:0044422 | organelle part | 3.95679878990212e-06 |
| GO:0007059 | chromosome segregation | 5.08436914316912e-06 |
| GO:0004672 | protein kinase activity | 1.34923448539993e-05 |
| GO:0051726 | regulation of cell cycle | 1.56939896772251e-05 |
| GO:0000910 | cytokinesis | 1.58585477378526e-05 |
| GO:0015630 | microtubule cytoskeleton | 3.39123823793808e-05 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 5.25615099083774e-05 |
| GO:0016301 | kinase activity | 8.87708698217631e-05 |
| GO:0043687 | post-translational protein modification | 0.000180430799812609 |
| GO:0000070 | mitotic sister chromatid segregation | 0.000252030120370413 |
| GO:0000819 | sister chromatid segregation | 0.000252030120370413 |
| GO:0044430 | cytoskeletal part | 0.000294355970171273 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 0.000294355970171273 |
| GO:0005874 | microtubule | 0.000294355970171273 |
| GO:0000166 | nucleotide binding | 0.000494032795681147 |
| GO:0043229 | intracellular organelle | 0.000494032795681147 |
| GO:0043226 | organelle | 0.000494032795681147 |
| GO:0003777 | microtubule motor activity | 0.000505422407726698 |
| GO:0005524 | ATP binding | 0.000556982811378001 |
| GO:0006260 | DNA replication | 0.000556982811378001 |
| GO:0000801 | central element | 0.000582992732372436 |
| GO:0006464 | protein modification process | 0.000582992732372436 |
| GO:0032559 | adenyl ribonucleotide binding | 0.000582992732372436 |
| GO:0006468 | protein amino acid phosphorylation | 0.000585366207086157 |
| GO:0006996 | organelle organization and biogenesis | 0.000737750600726981 |
| GO:0000794 | condensed nuclear chromosome | 0.000774884105448121 |
| GO:0007127 | meiosis I | 0.000774884105448121 |
| GO:0043412 | biopolymer modification | 0.000785149151412593 |
| GO:0000228 | nuclear chromosome | 0.000796153639353472 |
| GO:0030554 | adenyl nucleotide binding | 0.000814291696431081 |
| GO:0051276 | chromosome organization and biogenesis | 0.00109393948773557 |
| GO:0016310 | phosphorylation | 0.00113744853852033 |
| GO:0007017 | microtubule-based process | 0.00151388958990548 |
| GO:0005622 | intracellular | 0.00154075664745744 |
| GO:0000074 | regulation of progression through cell cycle | 0.00154075664745744 |
| GO:0005856 | cytoskeleton | 0.00155377679311978 |
| GO:0005875 | microtubule associated complex | 0.00195060377001823 |
| GO:0006259 | DNA metabolic process | 0.00311908774026783 |
| GO:0006793 | phosphorus metabolic process | 0.00335251251295851 |
| GO:0006796 | phosphate metabolic process | 0.00335251251295851 |
| GO:0032553 | ribonucleotide binding | 0.00352423973104953 |
| GO:0032555 | purine ribonucleotide binding | 0.00352423973104953 |
| GO:0007129 | synapsis | 0.00408235542320438 |
| GO:0044424 | intracellular part | 0.00413716403331301 |
| GO:0017076 | purine nucleotide binding | 0.00489846206117519 |
| GO:0044454 | nuclear chromosome part | 0.00720823581324697 |
| GO:0000776 | kinetochore | 0.00786979640958395 |
| GO:0000795 | synaptonemal complex | 0.00871570269389151 |
| GO:0043231 | intracellular membrane-bound organelle | 0.00913973487769127 |
| GO:0043227 | membrane-bound organelle | 0.00917190599941111 |
| GO:0007346 | regulation of progression through mitotic cell cycle | 0.0103568536863254 |
| GO:0016538 | cyclin-dependent protein kinase regulator activity | 0.0112770017115633 |
| GO:0043283 | biopolymer metabolic process | 0.0117384447574178 |
| GO:0007018 | microtubule-based movement | 0.0120179366875721 |
| GO:0016740 | transferase activity | 0.0173676526985089 |
| GO:0042772 | DNA damage response, signal transduction resulting in transcription | 0.0173676526985089 |
| GO:0008054 | cyclin catabolic process | 0.0173676526985089 |
| GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 0.0173676526985089 |
| GO:0048478 | replication fork protection | 0.0173676526985089 |
| GO:0031625 | ubiquitin protein ligase binding | 0.0173676526985089 |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 0.0177134065082344 |
| GO:0005635 | nuclear envelope | 0.0230199955487026 |
| GO:0006974 | response to DNA damage stimulus | 0.0273197900990334 |
| GO:0000940 | outer kinetochore of condensed chromosome | 0.0307105649515775 |
| GO:0008334 | histone mRNA metabolic process | 0.0307105649515775 |
| GO:0051220 | cytoplasmic sequestering of protein | 0.0307105649515775 |
| GO:0001716 | L-amino-acid oxidase activity | 0.0307105649515775 |
| GO:0042994 | cytoplasmic sequestering of transcription factor | 0.0307105649515775 |
| GO:0010225 | response to UV-C | 0.0307105649515775 |
| GO:0008608 | attachment of spindle microtubules to kinetochore | 0.0307105649515775 |
| GO:0006398 | histone mRNA 3'-end processing | 0.0307105649515775 |
| GO:0009719 | response to endogenous stimulus | 0.0321817238295457 |
| GO:0007276 | gamete generation | 0.0321817238295457 |
| GO:0016043 | cellular component organization and biogenesis | 0.0321817238295457 |
| GO:0044428 | nuclear part | 0.0371554930705214 |
| GO:0007141 | male meiosis I | 0.0416594668065179 |
| GO:0005095 | GTPase inhibitor activity | 0.0416594668065179 |
| GO:0050774 | negative regulation of dendrite morphogenesis | 0.0416594668065179 |
| GO:0031573 | intra-S DNA damage checkpoint | 0.0416594668065179 |
| GO:0008518 | reduced folate carrier activity | 0.0416594668065179 |
| GO:0007089 | traversing start control point of mitotic cell cycle | 0.0416594668065179 |
| GO:0006512 | ubiquitin cycle | 0.0433078326437268 |
| GO:0005083 | small GTPase regulator activity | 0.0465867594713286 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.0465867594713286 |
| GO:0019953 | sexual reproduction | 0.0491705653225339 |
| GO:0030695 | GTPase regulator activity | 0.0492954483949226 |
| GO:0033205 | cytokinesis during cell cycle | 0.0498248338747191 |
| GO:0051224 | negative regulation of protein transport | 0.0498248338747191 |
| GO:0046823 | negative regulation of nucleocytoplasmic transport | 0.0498248338747191 |
| GO:0000777 | condensed chromosome kinetochore | 0.0498248338747191 |
| GO:0042308 | negative regulation of protein import into nucleus | 0.0498248338747191 |
| GO:0042992 | negative regulation of transcription factor import into nucleus | 0.0498248338747191 |
| GO:0045931 | positive regulation of progression through mitotic cell cycle | 0.0498248338747191 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| primordium | 3.23e-07 | 134 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.40539 |
| MA0004.1 | 0.664995 |
| MA0006.1 | 2.04308 |
| MA0007.1 | 0.611716 |
| MA0009.1 | 0.4417 |
| MA0014.1 | 3.69101 |
| MA0017.1 | 0.378927 |
| MA0019.1 | 0.0625856 |
| MA0024.1 | 6.50814 |
| MA0025.1 | 0.290379 |
| MA0027.1 | 1.58064 |
| MA0028.1 | 2.16164 |
| MA0029.1 | 0.110598 |
| MA0030.1 | 0.113716 |
| MA0031.1 | 0.321618 |
| MA0038.1 | 1.25335 |
| MA0040.1 | 0.150335 |
| MA0041.1 | 0.0575895 |
| MA0042.1 | 0.22529 |
| MA0043.1 | 1.09587 |
| MA0046.1 | 0.163356 |
| MA0048.1 | 0.827896 |
| MA0050.1 | 0.534642 |
| MA0051.1 | 0.311762 |
| MA0052.1 | 0.154763 |
| MA0055.1 | 0.0235698 |
| MA0056.1 | 0 |
| MA0057.1 | 0.113862 |
| MA0058.1 | 0.773365 |
| MA0059.1 | 0.591937 |
| MA0060.1 | 24.101 |
| MA0061.1 | 1.21968 |
| MA0063.1 | 0 |
| MA0066.1 | 0.117158 |
| MA0067.1 | 1.73168 |
| MA0068.1 | 0.026325 |
| MA0069.1 | 0.154951 |
| MA0070.1 | 0.149628 |
| MA0071.1 | 0.0120294 |
| MA0072.1 | 0.145044 |
| MA0073.1 | 5.7206e-05 |
| MA0074.1 | 0.0923804 |
| MA0076.1 | 2.5733 |
| MA0077.1 | 0.825305 |
| MA0078.1 | 0.159531 |
| MA0081.1 | 0.283991 |
| MA0083.1 | 0.198862 |
| MA0084.1 | 0.648071 |
| MA0087.1 | 0.173051 |
| MA0088.1 | 2.43723 |
| MA0089.1 | 0 |
| MA0090.1 | 0.343094 |
| MA0091.1 | 0.268395 |
| MA0092.1 | 0.0875239 |
| MA0093.1 | 0.524033 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 5.91712 |
| MA0101.1 | 1.17268 |
| MA0103.1 | 0.414717 |
| MA0105.1 | 0.882096 |
| MA0106.1 | 1.48038 |
| MA0107.1 | 0.5776 |
| MA0108.2 | 0.0708441 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0990902 |
| MA0113.1 | 0.331635 |
| MA0114.1 | 0.549546 |
| MA0115.1 | 0.20108 |
| MA0116.1 | 1.10358 |
| MA0117.1 | 1.02496 |
| MA0119.1 | 0.255297 |
| MA0122.1 | 0.193454 |
| MA0124.1 | 0.332586 |
| MA0125.1 | 0.278915 |
| MA0130.1 | 0 |
| MA0131.1 | 5.79476 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.222323 |
| MA0136.1 | 0.105718 |
| MA0139.1 | 1.35291 |
| MA0140.1 | 0.0850147 |
| MA0141.1 | 0.0375835 |
| MA0142.1 | 0.0910287 |
| MA0143.1 | 0.0399933 |
| MA0144.1 | 0.272616 |
| MA0145.1 | 0.00672333 |
| MA0146.1 | 3.01492 |
| MA0147.1 | 0.838993 |
| MA0148.1 | 0.133377 |
| MA0149.1 | 0.00323152 |
| MA0062.2 | 4.22844 |
| MA0035.2 | 0.0879378 |
| MA0039.2 | 2.84679 |
| MA0138.2 | 0.0583125 |
| MA0002.2 | 0.29059 |
| MA0137.2 | 0.473238 |
| MA0104.2 | 0.841049 |
| MA0047.2 | 0.124805 |
| MA0112.2 | 0.0258614 |
| MA0065.2 | 0.026241 |
| MA0150.1 | 0.0356481 |
| MA0151.1 | 0 |
| MA0152.1 | 0.296975 |
| MA0153.1 | 0.233143 |
| MA0154.1 | 0.0918945 |
| MA0155.1 | 0.523509 |
| MA0156.1 | 0.28152 |
| MA0157.1 | 0.0778671 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0680834 |
| MA0160.1 | 0.479842 |
| MA0161.1 | 0 |
| MA0162.1 | 4.16848 |
| MA0163.1 | 0.4459 |
| MA0164.1 | 0.484537 |
| MA0080.2 | 0.142171 |
| MA0018.2 | 1.60277 |
| MA0099.2 | 0.0562189 |
| MA0079.2 | 0.311032 |
| MA0102.2 | 0.695093 |
| MA0258.1 | 0.0362695 |
| MA0259.1 | 2.87778 |
| MA0442.1 | 0 |
