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MCL coexpression mm9:2236

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Phase1 CAGE Peaks

 Short description
Mm9::chr18:36675421..36675441,-p1@Hbegf
Mm9::chr2:157252140..157252163,+p@chr2:157252140..157252163
+
Mm9::chr4:140857143..140857165,+p1@Epha2
Mm9::chr4:140857174..140857191,+p2@Epha2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.00445576646397867
GO:0051547regulation of keratinocyte migration0.00445576646397867
GO:0051549positive regulation of keratinocyte migration0.00445576646397867
GO:0007167enzyme linked receptor protein signaling pathway0.00445576646397867
GO:0035313wound healing, spreading of epidermal cells0.00445576646397867
GO:0051546keratinocyte migration0.00445576646397867
GO:0048660regulation of smooth muscle cell proliferation0.00501259994799517
GO:0048661positive regulation of smooth muscle cell proliferation0.00501259994799517
GO:0048013ephrin receptor signaling pathway0.00594069644327627
GO:0048659smooth muscle cell proliferation0.00668310040004472
GO:0005154epidermal growth factor receptor binding0.0085052980762432
GO:0007173epidermal growth factor receptor signaling pathway0.0115815017255876
GO:0033002muscle cell proliferation0.0115815017255876
GO:0001832blastocyst growth0.0115815017255876
GO:0030335positive regulation of cell migration0.0115815017255876
GO:0005003ephrin receptor activity0.011692541896481
GO:0051272positive regulation of cell motility0.0118774867822091
GO:0040017positive regulation of locomotion0.0118774867822091
GO:0001824blastocyst development0.0217924773575434
GO:0008016regulation of heart contraction0.0240387276318145
GO:0060047heart contraction0.0267038382121677
GO:0003015heart process0.0267038382121677
GO:0048589developmental growth0.0278618177049497
GO:0030334regulation of cell migration0.0289228106436236
GO:0008201heparin binding0.0300261630548748
GO:0051270regulation of cell motility0.0300261630548748
GO:0004714transmembrane receptor protein tyrosine kinase activity0.0300261630548748
GO:0040012regulation of locomotion0.0300261630548748
GO:0019199transmembrane receptor protein kinase activity0.0318460985768946
GO:0048731system development0.0318460985768946
GO:0005539glycosaminoglycan binding0.0318460985768946
GO:0042060wound healing0.0327396349799411
GO:0030247polysaccharide binding0.0327396349799411
GO:0001871pattern binding0.0333422625437847
GO:0008015blood circulation0.0351849469234926
GO:0003013circulatory system process0.0351849469234926
GO:0048856anatomical structure development0.0358607299173444
GO:0005615extracellular space0.0373803585216228
GO:0001701in utero embryonic development0.0398940445984346
GO:0044421extracellular region part0.0398940445984346
GO:0007275multicellular organismal development0.0405409865804409
GO:0001525angiogenesis0.042809770135942
GO:0008083growth factor activity0.0461327160541062
GO:0004713protein-tyrosine kinase activity0.047494422583449
GO:0007166cell surface receptor linked signal transduction0.0491461654119847
GO:0048514blood vessel morphogenesis0.0498176652640601
GO:0008284positive regulation of cell proliferation0.0498176652640601



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
epithelial cell5.08e-1125
endodermal cell3.40e-0920
endo-epithelial cell3.86e-0815
intestinal epithelial cell3.27e-079
epithelial cell of alimentary canal3.27e-079


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.600426
MA0004.10.6888
MA0006.10.497533
MA0007.10.672186
MA0009.11.15569
MA0014.10.276754
MA0017.10.528196
MA0019.10.964875
MA0024.11.11019
MA0025.11.39562
MA0027.12.81824
MA0028.10.509589
MA0029.11.08753
MA0030.11.09438
MA0031.11.05719
MA0038.10.846479
MA0040.11.16866
MA0041.10.604221
MA0042.10.589368
MA0043.11.25564
MA0046.11.1929
MA0048.10.266382
MA0050.10.731539
MA0051.10.856094
MA0052.11.17701
MA0055.10.396346
MA0056.10
MA0057.10.701847
MA0058.10.581673
MA0059.10.59559
MA0060.10.403071
MA0061.10.438628
MA0063.10
MA0066.11.94802
MA0067.11.50873
MA0068.10.256913
MA0069.11.17737
MA0070.11.16732
MA0071.10.73062
MA0072.11.15853
MA0073.12.08592
MA0074.10.795862
MA0076.10.550092
MA0077.11.13603
MA0078.10.891476
MA0081.10.621611
MA0083.11.25482
MA0084.11.84013
MA0087.11.21037
MA0088.10.201215
MA0089.10
MA0090.11.56748
MA0091.10.703314
MA0092.10.651119
MA0093.10.519148
MA0095.10
MA0098.10
MA0100.10.783305
MA0101.10.605676
MA0103.10.540576
MA0105.10.313353
MA0106.10.899777
MA0107.10.533522
MA0108.20.989014
MA0109.10
MA0111.10.666525
MA0113.10.869608
MA0114.10.43587
MA0115.11.25852
MA0116.10.497293
MA0117.11.22527
MA0119.11.47447
MA0122.11.24573
MA0124.11.45461
MA0125.11.37907
MA0130.10
MA0131.10.960068
MA0132.10
MA0133.10
MA0135.11.29308
MA0136.10.817395
MA0139.10.957842
MA0140.10.78318
MA0141.11.38335
MA0142.11.04199
MA0143.10.887119
MA0144.11.11951
MA0145.10.21199
MA0146.10.313734
MA0147.11.15069
MA0148.10.706718
MA0149.10.611881
MA0062.20.319836
MA0035.20.788288
MA0039.21.91986
MA0138.20.951653
MA0002.20.368961
MA0137.20.559766
MA0104.21.0034
MA0047.20.845655
MA0112.21.79184
MA0065.21.14711
MA0150.10.67206
MA0151.10
MA0152.10.84577
MA0153.11.31015
MA0154.10.263609
MA0155.11.21457
MA0156.10.549102
MA0157.11.0083
MA0158.10
MA0159.11.1762
MA0160.10.71003
MA0161.10
MA0162.10.704935
MA0163.11.11502
MA0164.10.817786
MA0080.20.534538
MA0018.21.93488
MA0099.20.944966
MA0079.20.814354
MA0102.21.8929
MA0258.11.07695
MA0259.11.12353
MA0442.10
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