MCL coexpression mm9:258
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0019835 | cytolysis | 2.53419807642747e-14 |
| GO:0004252 | serine-type endopeptidase activity | 2.59989400226143e-06 |
| GO:0017171 | serine hydrolase activity | 2.59989400226143e-06 |
| GO:0008236 | serine-type peptidase activity | 2.59989400226143e-06 |
| GO:0005615 | extracellular space | 3.26456462623991e-06 |
| GO:0008219 | cell death | 3.96799342549326e-06 |
| GO:0044421 | extracellular region part | 3.96799342549326e-06 |
| GO:0016265 | death | 3.96799342549326e-06 |
| GO:0048468 | cell development | 1.75622708928195e-05 |
| GO:0048869 | cellular developmental process | 4.46779780721031e-05 |
| GO:0030154 | cell differentiation | 4.46779780721031e-05 |
| GO:0004175 | endopeptidase activity | 6.86183091701417e-05 |
| GO:0006508 | proteolysis | 0.00052187985334583 |
| GO:0008233 | peptidase activity | 0.000803721231104847 |
| GO:0032502 | developmental process | 0.00322055582686556 |
| GO:0005605 | basal lamina | 0.00569053171091571 |
| GO:0016787 | hydrolase activity | 0.00923687981078232 |
| GO:0004278 | granzyme B activity | 0.014416808195913 |
| GO:0032426 | stereocilium bundle tip | 0.014416808195913 |
| GO:0008626 | induction of apoptosis by granzyme | 0.014416808195913 |
| GO:0005201 | extracellular matrix structural constituent | 0.0231198544623718 |
| GO:0005604 | basement membrane | 0.0235484112202604 |
| GO:0001917 | photoreceptor inner segment | 0.0332367573478983 |
| GO:0043259 | laminin-10 complex | 0.0332367573478983 |
| GO:0044420 | extracellular matrix part | 0.0416924805907267 |
| GO:0048563 | post-embryonic organ morphogenesis | 0.0479613305053664 |
| GO:0009401 | phosphoenolpyruvate-dependent sugar phosphotransferase system | 0.0479613305053664 |
| GO:0060013 | righting reflex | 0.0479613305053664 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| extraembryonic membrane | 6.04e-65 | 3 |
| extraembryonic structure | 6.04e-65 | 3 |
| membranous layer | 6.04e-65 | 3 |
| embryonic uterus | 1.60e-49 | 4 |
| uterus | 1.60e-49 | 4 |
| placenta | 4.55e-44 | 2 |
| chorion | 4.55e-44 | 2 |
| allantois | 4.55e-44 | 2 |
| internal female genitalia | 7.27e-40 | 5 |
| female reproductive organ | 2.39e-25 | 8 |
| uterus or analog | 3.06e-23 | 1 |
| internal genitalia | 1.19e-22 | 9 |
| female reproductive system | 1.19e-22 | 9 |
| amnion | 1.39e-22 | 1 |
| female organism | 1.00e-18 | 11 |
| reproductive organ | 4.35e-09 | 24 |
| organ component layer | 5.26e-09 | 24 |
| reproductive structure | 1.87e-08 | 26 |
| reproductive system | 1.87e-08 | 26 |
| somatic layer of lateral plate mesoderm | 1.88e-08 | 3 |
| adult organism | 1.20e-07 | 51 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00180534 |
| MA0004.1 | 0.075713 |
| MA0006.1 | 0.02081 |
| MA0007.1 | 0.244089 |
| MA0009.1 | 0.356735 |
| MA0014.1 | 0.000178993 |
| MA0017.1 | 0.507679 |
| MA0019.1 | 0.221321 |
| MA0024.1 | 0.322453 |
| MA0025.1 | 0.553002 |
| MA0027.1 | 1.91746 |
| MA0028.1 | 0.0230932 |
| MA0029.1 | 0.824884 |
| MA0030.1 | 0.31081 |
| MA0031.1 | 0.284004 |
| MA0038.1 | 0.150331 |
| MA0040.1 | 0.366712 |
| MA0041.1 | 0.17625 |
| MA0042.1 | 0.0421363 |
| MA0043.1 | 0.435645 |
| MA0046.1 | 0.385571 |
| MA0048.1 | 0.0232488 |
| MA0050.1 | 0.642953 |
| MA0051.1 | 0.155655 |
| MA0052.1 | 0.373177 |
| MA0055.1 | 0.177583 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0181772 |
| MA0058.1 | 0.0399952 |
| MA0059.1 | 0.168372 |
| MA0060.1 | 0.116099 |
| MA0061.1 | 0.0572065 |
| MA0063.1 | 0 |
| MA0066.1 | 0.869432 |
| MA0067.1 | 0.652366 |
| MA0068.1 | 0.0532285 |
| MA0069.1 | 0.373449 |
| MA0070.1 | 1.70613 |
| MA0071.1 | 1.58013 |
| MA0072.1 | 0.358914 |
| MA0073.1 | 0.00126875 |
| MA0074.1 | 1.27449 |
| MA0076.1 | 0.0318933 |
| MA0077.1 | 0.341791 |
| MA0078.1 | 0.521853 |
| MA0081.1 | 0.192641 |
| MA0083.1 | 1.10972 |
| MA0084.1 | 0.958921 |
| MA0087.1 | 0.399335 |
| MA0088.1 | 0.0063216 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0615811 |
| MA0091.1 | 0.278396 |
| MA0092.1 | 0.221993 |
| MA0093.1 | 0.0250118 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.117472 |
| MA0101.1 | 0.177595 |
| MA0103.1 | 0.291843 |
| MA0105.1 | 0.00212066 |
| MA0106.1 | 0.18086 |
| MA0107.1 | 0.11696 |
| MA0108.2 | 0.667582 |
| MA0109.1 | 0 |
| MA0111.1 | 0.238061 |
| MA0113.1 | 0.950645 |
| MA0114.1 | 0.150918 |
| MA0115.1 | 0.437985 |
| MA0116.1 | 0.0207662 |
| MA0117.1 | 0.411186 |
| MA0119.1 | 0.400754 |
| MA0122.1 | 0.427622 |
| MA0124.1 | 0.604388 |
| MA0125.1 | 0.538769 |
| MA0130.1 | 0 |
| MA0131.1 | 0.218222 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.466327 |
| MA0136.1 | 1.94399 |
| MA0139.1 | 0.027105 |
| MA0140.1 | 0.374733 |
| MA0141.1 | 2.87773 |
| MA0142.1 | 0.27329 |
| MA0143.1 | 0.515613 |
| MA0144.1 | 1.5032 |
| MA0145.1 | 0.0575932 |
| MA0146.1 | 9.16865e-05 |
| MA0147.1 | 0.0652636 |
| MA0148.1 | 0.0829136 |
| MA0149.1 | 0.0487792 |
| MA0062.2 | 0.224697 |
| MA0035.2 | 0.381271 |
| MA0039.2 | 0.00457508 |
| MA0138.2 | 0.212837 |
| MA0002.2 | 2.64742 |
| MA0137.2 | 0.0342582 |
| MA0104.2 | 0.0063375 |
| MA0047.2 | 0.149878 |
| MA0112.2 | 0.831351 |
| MA0065.2 | 0.835053 |
| MA0150.1 | 0.243955 |
| MA0151.1 | 0 |
| MA0152.1 | 0.149941 |
| MA0153.1 | 0.480495 |
| MA0154.1 | 0.354879 |
| MA0155.1 | 0.14685 |
| MA0156.1 | 3.98339 |
| MA0157.1 | 0.250083 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0719173 |
| MA0160.1 | 1.00658 |
| MA0161.1 | 0 |
| MA0162.1 | 2.89931e-05 |
| MA0163.1 | 0.0286214 |
| MA0164.1 | 0.134941 |
| MA0080.2 | 2.65178 |
| MA0018.2 | 1.99059 |
| MA0099.2 | 1.13206 |
| MA0079.2 | 1.40231e-06 |
| MA0102.2 | 1.0092 |
| MA0258.1 | 1.77793 |
| MA0259.1 | 0.0586005 |
| MA0442.1 | 0 |
