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Coexpression cluster:C4843: Difference between revisions

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|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00663341566104044!SETDB1#9869;3:40.3200261780105:1.52461559299059e-05:0.000360328870595936!TRIM28#10155;3:18.5905250452625:0.000155596929725528:0.00198247990040312!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110303128180213
|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00663341566104044!SETDB1#9869;3:40.3200261780105:1.52461559299059e-05:0.000360328870595936!TRIM28#10155;3:18.5905250452625:0.000155596929725528:0.00198247990040312!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0110303128180213
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}}
}}

Revision as of 17:00, 26 November 2012


Full id: C4843_Small_amniotic_uterus_Amniotic_smooth_Mesenchymal_salivary



Phase1 CAGE Peaks

Hg19::chrX:107683009..107683088,+p1@COL4A5
Hg19::chrX:107683096..107683121,+p3@COL4A5
Hg19::chrX:107683216..107683245,+p6@COL4A5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
epithelial cell1.43e-14253
embryonic cell1.98e-11250
smooth muscle cell6.95e-0843
smooth muscle myoblast6.95e-0843
endo-epithelial cell3.19e-0742
extraembryonic cell5.93e-0719
Uber Anatomy
Ontology termp-valuen
multi-tissue structure7.21e-20342
endoderm-derived structure1.04e-19160
endoderm1.04e-19160
presumptive endoderm1.04e-19160
anatomical cluster3.58e-18373
embryo2.76e-15592
digestive system3.97e-14145
digestive tract3.97e-14145
primitive gut3.97e-14145
developing anatomical structure1.25e-13581
embryonic structure1.26e-13564
multi-cellular organism5.44e-13656
organism subdivision6.47e-13264
epithelium2.67e-12306
germ layer2.80e-12560
germ layer / neural crest2.80e-12560
embryonic tissue2.80e-12560
presumptive structure2.80e-12560
germ layer / neural crest derived structure2.80e-12560
epiblast (generic)2.80e-12560
cell layer6.55e-12309
subdivision of digestive tract1.97e-11118
anatomical conduit2.73e-10240
mesenchyme3.10e-10160
entire embryonic mesenchyme3.10e-10160
trunk mesenchyme4.67e-10122
anatomical system8.25e-10624
anatomical group1.18e-09625
primordium1.24e-09160
reproductive structure5.96e-0959
reproductive system5.96e-0959
respiratory system7.65e-0974
organ part2.55e-08218
organ system subdivision6.93e-08223
trunk1.81e-07199
reproductive organ2.51e-0748
unilaminar epithelium2.70e-07148
organ2.77e-07503
multilaminar epithelium2.89e-0783
endo-epithelium3.10e-0782
orifice4.65e-0736
female organism7.78e-0741


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00663341566104044
SETDB1#9869340.32002617801051.52461559299059e-050.000360328870595936
TRIM28#10155318.59052504526250.0001555969297255280.00198247990040312
ZNF263#1012738.221841637010680.001799043925565870.0110303128180213



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.