MCL coexpression mm9:437

Phase1 CAGE Peaks

	Short description
Mm9::chr10:69227401..69227417,+	p@chr10:69227401..69227417 +
Mm9::chr14:55674497..55674515,+	p@chr14:55674497..55674515 +
Mm9::chr14:65036618..65036627,-	p@chr14:65036618..65036627 -
Mm9::chr16:42921903..42921908,+	p@chr16:42921903..42921908 +
Mm9::chr16:42921959..42921969,+	p@chr16:42921959..42921969 +
Mm9::chr16:42921974..42921981,+	p@chr16:42921974..42921981 +
Mm9::chr16:77421892..77421903,+	p@chr16:77421892..77421903 +
Mm9::chr16:91868147..91868189,+	p@chr16:91868147..91868189 +
Mm9::chr18:69679247..69679264,+	p@chr18:69679247..69679264 +
Mm9::chr18:69679337..69679354,+	p@chr18:69679337..69679354 +
Mm9::chr1:179393159..179393161,-	p@chr1:179393159..179393161 -
Mm9::chr2:52182494..52182501,-	p@chr2:52182494..52182501 -
Mm9::chr2:77655482..77655519,-	p22@Zfp385b
Mm9::chr2:77655548..77655551,-	p28@Zfp385b
Mm9::chr4:153471214..153471223,-	p3@Trp73
Mm9::chr5:123435005..123435006,-	p33@Kdm2b
Mm9::chr5:17080335..17080346,+	p12@Sema3c

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0009791	post-embryonic development	0.00287473216175041
GO:0033326	cerebrospinal fluid secretion	0.0125631121505351
GO:0030215	semaphorin receptor binding	0.0125631121505351
GO:0051864	histone demethylase activity (H3-K36 specific)	0.0125631121505351
GO:0043508	negative regulation of JNK activity	0.0125631121505351
GO:0032452	histone demethylase activity	0.0125631121505351
GO:0002039	p53 binding	0.018840022401468
GO:0032451	demethylase activity	0.018840022401468
GO:0045793	positive regulation of cell size	0.018840022401468
GO:0021766	hippocampus development	0.018840022401468
GO:0021761	limbic system development	0.0318673956740005
GO:0001836	release of cytochrome c from mitochondria	0.0318673956740005
GO:0007589	fluid secretion	0.0318673956740005
GO:0048546	digestive tract morphogenesis	0.033219782953293
GO:0021543	pallium development	0.033219782953293
GO:0043506	regulation of JNK activity	0.033219782953293
GO:0001974	blood vessel remodeling	0.033219782953293
GO:0043407	negative regulation of MAP kinase activity	0.033916940711099
GO:0008270	zinc ion binding	0.033916940711099
GO:0008637	apoptotic mitochondrial changes	0.035199655579238
GO:0009887	organ morphogenesis	0.035199655579238
GO:0001755	neural crest cell migration	0.0360566569316459
GO:0043524	negative regulation of neuron apoptosis	0.0360566569316459
GO:0021537	telencephalon development	0.0360566569316459
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.0376181525092354
GO:0007399	nervous system development	0.0407061218599463
GO:0014032	neural crest cell development	0.0407061218599463
GO:0014033	neural crest cell differentiation	0.0407061218599463
GO:0046914	transition metal ion binding	0.0407061218599463
GO:0043523	regulation of neuron apoptosis	0.0407061218599463
GO:0006469	negative regulation of protein kinase activity	0.0407061218599463
GO:0033673	negative regulation of kinase activity	0.0407061218599463
GO:0051402	neuron apoptosis	0.0407061218599463
GO:0051348	negative regulation of transferase activity	0.0407061218599463
GO:0048762	mesenchymal cell differentiation	0.0407061218599463
GO:0014031	mesenchymal cell development	0.0407061218599463
GO:0007050	cell cycle arrest	0.0456766426830352
GO:0043086	negative regulation of catalytic activity	0.0464436380388674
GO:0008632	apoptotic program	0.0471706680793689

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
neuron of cerebral cortex	1.08e-12	6

Uber Anatomy

Ontology term	p-value	n
cerebral cortex	3.28e-10	21
cerebral hemisphere	3.28e-10	21
pallium	3.28e-10	21
brain grey matter	3.01e-09	29
regional part of telencephalon	3.01e-09	29
telencephalon	3.01e-09	29
regional part of forebrain	2.34e-08	39
forebrain	2.34e-08	39
future forebrain	2.34e-08	39
anterior neural tube	4.08e-08	40
gray matter	9.93e-08	34
regional part of brain	6.97e-07	46

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}