MCL coexpression mm9:453

Phase1 CAGE Peaks

	Short description
Mm9::chr10:33816270..33816273,-	p6@Fam26e
Mm9::chr13:49703399..49703432,+	p1@Ogn
Mm9::chr13:49718335..49718348,+	p@chr13:49718335..49718348 +
Mm9::chr14:47006937..47006958,-	p@chr14:47006937..47006958 -
Mm9::chr14:47006973..47006987,-	p@chr14:47006973..47006987 -
Mm9::chr15:54684962..54684979,-	p@chr15:54684962..54684979 -
Mm9::chr17:80114052..80114087,-	p3@Cyp1b1
Mm9::chr1:172040854..172040860,-	p9@Ddr2
Mm9::chr1:95196851..95196860,+	p@chr1:95196851..95196860 +
Mm9::chr2:125860373..125860382,+	p7@Fgf7
Mm9::chr2:125860383..125860401,+	p1@Fgf7
Mm9::chr2:125860402..125860415,+	p3@Fgf7
Mm9::chr2:125860501..125860530,+	p2@Fgf7
Mm9::chr2:125860531..125860544,+	p4@Fgf7
Mm9::chr2:125861402..125861426,+	p@chr2:125861402..125861426 +
Mm9::chr2:125861431..125861460,+	p@chr2:125861431..125861460 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008083	growth factor activity	0.00122733627288827
GO:0007500	mesodermal cell fate determination	0.0162561456218623
GO:0005102	receptor binding	0.0162561456218623
GO:0021978	telencephalon regionalization	0.0162561456218623
GO:0048522	positive regulation of cellular process	0.0162561456218623
GO:0044421	extracellular region part	0.0162561456218623
GO:0032331	negative regulation of chondrocyte differentiation	0.0162561456218623
GO:0032330	regulation of chondrocyte differentiation	0.0162561456218623
GO:0045662	negative regulation of myoblast differentiation	0.0162561456218623
GO:0001710	mesodermal cell fate commitment	0.0162561456218623
GO:0048333	mesodermal cell differentiation	0.0162561456218623
GO:0048518	positive regulation of biological process	0.0162561456218623
GO:0008284	positive regulation of cell proliferation	0.0162561456218623
GO:0021904	dorsoventral neural tube patterning	0.0170144388354342
GO:0030501	positive regulation of bone mineralization	0.0170144388354342
GO:0005125	cytokine activity	0.0194654964544927
GO:0045778	positive regulation of ossification	0.0210468324063134
GO:0021871	forebrain regionalization	0.0210468324063134
GO:0046852	positive regulation of bone remodeling	0.0210468324063134
GO:0045669	positive regulation of osteoblast differentiation	0.0210468324063134
GO:0045843	negative regulation of striated muscle development	0.0210468324063134
GO:0007167	enzyme linked receptor protein signaling pathway	0.0210468324063134
GO:0021532	neural tube patterning	0.0210468324063134
GO:0045661	regulation of myoblast differentiation	0.0210468324063134
GO:0005578	proteinaceous extracellular matrix	0.0210468324063134
GO:0051145	smooth muscle cell differentiation	0.0220739524444176
GO:0042127	regulation of cell proliferation	0.0250632321560463
GO:0045667	regulation of osteoblast differentiation	0.0273206722856267
GO:0016202	regulation of striated muscle development	0.028573663789643
GO:0050679	positive regulation of epithelial cell proliferation	0.0298721632535791
GO:0002062	chondrocyte differentiation	0.0298721632535791
GO:0030500	regulation of bone mineralization	0.0298721632535791
GO:0001658	ureteric bud branching	0.0347489098758318
GO:0005104	fibroblast growth factor receptor binding	0.0355966978373871
GO:0008283	cell proliferation	0.0365611800202646
GO:0030282	bone mineralization	0.0365611800202646
GO:0050678	regulation of epithelial cell proliferation	0.0365611800202646
GO:0030278	regulation of ossification	0.0365611800202646
GO:0001709	cell fate determination	0.0365611800202646
GO:0001707	mesoderm formation	0.0365611800202646
GO:0048332	mesoderm morphogenesis	0.0365611800202646
GO:0001649	osteoblast differentiation	0.0365611800202646
GO:0001934	positive regulation of protein amino acid phosphorylation	0.0365611800202646
GO:0001704	formation of primary germ layer	0.0365611800202646
GO:0033240	positive regulation of amine metabolic process	0.0365611800202646
GO:0045764	positive regulation of amino acid metabolic process	0.0365611800202646
GO:0007281	germ cell development	0.0365611800202646
GO:0030509	BMP signaling pathway	0.0376583279657835
GO:0046850	regulation of bone remodeling	0.0376583279657835
GO:0050673	epithelial cell proliferation	0.0391437993405773
GO:0001657	ureteric bud development	0.0391437993405773
GO:0050381	unspecific monooxygenase activity	0.0391437993405773
GO:0045445	myoblast differentiation	0.0416472564852497
GO:0042475	odontogenesis of dentine-containing teeth	0.0416472564852497
GO:0006468	protein amino acid phosphorylation	0.0416472564852497
GO:0030218	erythrocyte differentiation	0.0416472564852497
GO:0042476	odontogenesis	0.0416472564852497
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	0.0416472564852497
GO:0005615	extracellular space	0.0419100510557126
GO:0009953	dorsal/ventral pattern formation	0.0455312993014895
GO:0016310	phosphorylation	0.0461018634925893
GO:0001656	metanephros development	0.0461018634925893
GO:0045597	positive regulation of cell differentiation	0.0463732300747337
GO:0051216	cartilage development	0.0476229337557569
GO:0007498	mesoderm development	0.0478619088067146
GO:0033238	regulation of amine metabolic process	0.0485354375447023
GO:0001932	regulation of protein amino acid phosphorylation	0.0485354375447023
GO:0006521	regulation of amino acid metabolic process	0.0485354375447023
GO:0042325	regulation of phosphorylation	0.0490433248316235
GO:0051174	regulation of phosphorus metabolic process	0.0490433248316235
GO:0019220	regulation of phosphate metabolic process	0.0490433248316235
GO:0048754	branching morphogenesis of a tube	0.0490433248316235
GO:0008201	heparin binding	0.0490433248316235
GO:0006793	phosphorus metabolic process	0.0490433248316235
GO:0006796	phosphate metabolic process	0.0490433248316235
GO:0007369	gastrulation	0.0490433248316235
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0490433248316235
GO:0001763	morphogenesis of a branching structure	0.0490433248316235
GO:0042692	muscle cell differentiation	0.0490433248316235
GO:0048741	skeletal muscle fiber development	0.0490433248316235
GO:0030324	lung development	0.0490433248316235
GO:0048747	muscle fiber development	0.0490433248316235
GO:0030323	respiratory tube development	0.0490433248316235
GO:0021915	neural tube development	0.0490433248316235

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
surface structure	5.19e-09	22
lung	7.96e-09	14
respiratory tube	7.96e-09	14
respiration organ	7.96e-09	14
pair of lungs	7.96e-09	14
lung primordium	7.96e-09	14
lung bud	7.96e-09	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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