MCL coexpression mm9:469

Phase1 CAGE Peaks

	Short description
Mm9::chr18:65382340..65382345,-	p@chr18:65382340..65382345 -
Mm9::chr2:5597108..5597111,-	p11@Camk1d
Mm9::chr3:121517222..121517245,-	p@chr3:121517222..121517245 -
Mm9::chr3:138037110..138037127,+	p1@Adh6-ps1
Mm9::chr4:41691973..41691986,-	p9@Sigmar1
Mm9::chr6:121087499..121087514,+	p@chr6:121087499..121087514 +
Mm9::chr7:15021789..15021806,-	p@chr7:15021789..15021806 -
Mm9::chr7:20283537..20283548,-	p@chr7:20283537..20283548 -
Mm9::chr8:129971569..129971578,+	p16@Pard3
Mm9::chr8:88125923..88125936,+	p@chr8:88125923..88125936 +
Mm9::chr8:88125941..88125950,+	p@chr8:88125941..88125950 +
Mm9::chr8:88125965..88125972,+	p@chr8:88125965..88125972 +
Mm9::chr8:89139298..89139300,+	p@chr8:89139298..89139300 +
Mm9::chr9:42070219..42070224,-	p@chr9:42070219..42070224 -
Mm9::chr9:42072287..42072302,-	p2@Sc5d
Mm9::chr9:62193253..62193260,+	p@chr9:62193253..62193260 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016125	sterol metabolic process	0.0124910973538596
GO:0050046	lathosterol oxidase activity	0.0124910973538596
GO:0046996	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated	0.0124910973538596
GO:0008202	steroid metabolic process	0.014831918205804
GO:0006707	cholesterol catabolic process	0.0214080307195393
GO:0016127	sterol catabolic process	0.0214080307195393
GO:0033344	cholesterol efflux	0.0214080307195393
GO:0006066	alcohol metabolic process	0.0218486435308822
GO:0006706	steroid catabolic process	0.0218486435308822
GO:0042627	chylomicron	0.0218486435308822
GO:0017127	cholesterol transporter activity	0.0218486435308822
GO:0015248	sterol transporter activity	0.0218486435308822
GO:0008034	lipoprotein binding	0.0318104378325636
GO:0042311	vasodilation	0.0318104378325636
GO:0030301	cholesterol transport	0.0318104378325636
GO:0004683	calmodulin-dependent protein kinase activity	0.0318104378325636
GO:0015918	sterol transport	0.0318104378325636
GO:0042632	cholesterol homeostasis	0.0318104378325636
GO:0055088	lipid homeostasis	0.0318104378325636
GO:0055092	sterol homeostasis	0.0318104378325636
GO:0044255	cellular lipid metabolic process	0.0361080724977768
GO:0007163	establishment and/or maintenance of cell polarity	0.0408027456076468
GO:0005913	cell-cell adherens junction	0.0415734311569283
GO:0006629	lipid metabolic process	0.0415734311569283
GO:0044242	cellular lipid catabolic process	0.0417010481539018
GO:0016126	sterol biosynthetic process	0.0417010481539018
GO:0003018	vascular process in circulatory system	0.0438151927516389
GO:0035150	regulation of tube size	0.0438151927516389
GO:0050880	regulation of blood vessel size	0.0438151927516389
GO:0005819	spindle	0.0473220262945199

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
metabolising cell	6.97e-11	5
endopolyploid cell	6.97e-11	5
parenchymal cell	6.97e-11	5
polyploid cell	6.97e-11	5
hepatocyte	6.97e-11	5
fibroblast	4.68e-07	1
hepatic stellate cell	4.68e-07	1

Uber Anatomy

Ontology term	p-value	n
liver	2.66e-41	22
epithelial sac	2.66e-41	22
digestive gland	2.66e-41	22
epithelium of foregut-midgut junction	2.66e-41	22
anatomical boundary	2.66e-41	22
hepatobiliary system	2.66e-41	22
foregut-midgut junction	2.66e-41	22
hepatic diverticulum	2.66e-41	22
liver primordium	2.66e-41	22
septum transversum	2.66e-41	22
liver bud	2.66e-41	22
digestive tract diverticulum	1.92e-39	23
sac	1.92e-39	23
exocrine gland	3.60e-36	25
exocrine system	3.60e-36	25
trunk mesenchyme	2.12e-19	45
epithelial tube	1.67e-18	47
abdomen element	1.11e-17	49
abdominal segment element	1.11e-17	49
abdominal segment of trunk	1.11e-17	49
abdomen	1.11e-17	49
gut epithelium	1.43e-15	55
endocrine gland	3.92e-14	60
mesenchyme	7.13e-14	61
entire embryonic mesenchyme	7.13e-14	61
gland	6.49e-13	65
unilaminar epithelium	1.08e-12	66
subdivision of trunk	1.08e-12	66
endo-epithelium	4.59e-12	69
foregut	6.64e-12	80
endocrine system	1.73e-11	72
immaterial anatomical entity	2.58e-10	79
trunk region element	2.58e-10	79
trunk	7.81e-09	90
subdivision of digestive tract	8.73e-08	114
digestive system	1.29e-07	116
digestive tract	1.29e-07	116
primitive gut	1.29e-07	116
endoderm-derived structure	1.87e-07	118
endoderm	1.87e-07	118
presumptive endoderm	1.87e-07	118

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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