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{{Coexpression_clusters
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|id=C2074
|ontology_enrichment_celltype=CL:0000055!2.26e-32!180;CL:0000057!1.42e-18!75;CL:0000680!7.69e-15!57;CL:0000056!7.69e-15!57;CL:0000355!7.69e-15!57;CL:0000187!3.15e-14!54;CL:0000183!3.93e-14!59;CL:0000393!1.50e-13!60;CL:0000211!1.50e-13!60;CL:0000136!8.86e-12!15;CL:0000192!9.41e-11!42;CL:0000514!9.41e-11!42;CL:0000359!1.13e-08!32;CL:0000222!2.04e-08!119;CL:0002334!1.25e-07!12
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000914!8.53e-20!83;UBERON:0002329!8.53e-20!83;UBERON:0003077!8.53e-20!83;UBERON:0003059!8.53e-20!83;UBERON:0007282!8.53e-20!83;UBERON:0009618!8.53e-20!83;UBERON:0007285!8.53e-20!83;UBERON:0004290!3.35e-19!70;UBERON:0002385!4.19e-17!63;UBERON:0001015!4.19e-17!63;UBERON:0000383!4.19e-17!63;UBERON:0001134!1.71e-16!61;UBERON:0002036!1.71e-16!61;UBERON:0003082!1.71e-16!61;UBERON:0004872!7.34e-16!84;UBERON:0000475!1.51e-15!365;UBERON:0000486!1.25e-14!82;UBERON:0001009!2.97e-13!113;UBERON:0007023!1.17e-12!115;UBERON:0004535!2.00e-12!110;UBERON:0000481!2.46e-11!347;UBERON:0007100!7.93e-11!27;UBERON:0002049!9.10e-11!79;UBERON:0007798!9.10e-11!79;UBERON:0005256!1.20e-10!143;UBERON:0000119!1.71e-10!312;UBERON:0000468!2.02e-10!659;UBERON:0001981!2.08e-10!60;UBERON:0007500!2.08e-10!60;UBERON:0004537!2.08e-10!60;UBERON:0006965!2.08e-10!60;UBERON:0000483!5.01e-10!309;UBERON:0000948!6.59e-10!24;UBERON:0005498!6.59e-10!24;UBERON:0004140!6.59e-10!24;UBERON:0009881!6.59e-10!24;UBERON:0004141!6.59e-10!24;UBERON:0003084!6.59e-10!24;UBERON:0007005!6.59e-10!24;UBERON:0004139!6.59e-10!24;UBERON:0004291!6.59e-10!24;UBERON:0001637!7.80e-10!42;UBERON:0003509!7.80e-10!42;UBERON:0004572!7.80e-10!42;UBERON:0001013!2.54e-09!14;UBERON:0000477!3.16e-09!286;UBERON:0000055!1.09e-08!69;UBERON:0002100!2.46e-08!216;UBERON:0004573!2.51e-08!33;UBERON:0004571!2.51e-08!33;UBERON:0004111!5.44e-08!241;UBERON:0000479!2.17e-07!787;UBERON:0003914!2.97e-07!118;UBERON:0003102!3.55e-07!95;UBERON:0000490!4.13e-07!138;UBERON:0000025!6.06e-07!194
}}

Latest revision as of 11:58, 17 September 2013


Full id: C2074_Mesenchymal_Osteoblast_Adipocyte_mature_Chondrocyte_Synoviocyte_Preadipocyte



Phase1 CAGE Peaks

Hg19::chr10:81892415..81892447,+p2@PLAC9
Hg19::chr10:81892478..81892493,+p1@PLAC9
Hg19::chr5:158527633..158527660,+p1@ENST00000523301
Hg19::chr5:158527667..158527701,+p1@ENST00000499583
p1@uc003lxm.1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
dense mesenchyme tissue1.45e-2073
somite2.87e-2071
presomitic mesoderm2.87e-2071
presumptive segmental plate2.87e-2071
dermomyotome2.87e-2071
trunk paraxial mesoderm2.87e-2071
paraxial mesoderm3.31e-2072
presumptive paraxial mesoderm3.31e-2072
muscle tissue4.48e-1864
musculature4.48e-1864
musculature of body4.48e-1864
skeletal muscle tissue1.71e-1762
striated muscle tissue1.71e-1762
myotome1.71e-1762
epithelial vesicle2.14e-1778
multilaminar epithelium5.58e-1683
splanchnic layer of lateral plate mesoderm2.14e-1483
multi-tissue structure1.01e-13342
structure with developmental contribution from neural crest1.64e-12132
trunk mesenchyme5.70e-12122
mesenchyme2.38e-11160
entire embryonic mesenchyme2.38e-11160
cell layer4.62e-11309
adult organism4.70e-11114
epithelium1.42e-10306
circulatory system1.62e-10112
primary circulatory organ2.11e-1027
multi-cellular organism2.37e-10656
vasculature2.91e-1078
vascular system2.91e-1078
cardiovascular system7.98e-10109
anatomical cluster9.01e-10373
organism subdivision1.04e-09264
adipose tissue1.30e-0914
heart1.31e-0924
primitive heart tube1.31e-0924
primary heart field1.31e-0924
anterior lateral plate mesoderm1.31e-0924
heart tube1.31e-0924
heart primordium1.31e-0924
cardiac mesoderm1.31e-0924
cardiogenic plate1.31e-0924
heart rudiment1.31e-0924
epithelial tube open at both ends2.73e-0959
blood vessel2.73e-0959
blood vasculature2.73e-0959
vascular cord2.73e-0959
unilaminar epithelium3.71e-09148
artery4.55e-0942
arterial blood vessel4.55e-0942
arterial system4.55e-0942
tissue4.20e-08773
vessel5.48e-0868
anatomical conduit8.21e-08240
systemic artery8.89e-0833
systemic arterial system8.89e-0833
surface structure1.19e-0799
trunk8.37e-07199
anatomical system9.43e-07624


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.45381
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.11.41335
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.11.01899
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.569905
MA0146.11.75643
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.12.49771
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.00408
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TAF1#687243.343046285745290.008005664898701650.0321109008508911



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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