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{{Coexpression_clusters
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|full_id=C2144_Basophils_CD14_Eosinophils_CD4_CD19_Natural_Mast
|id=C2144
|ontology_enrichment_celltype=CL:0000738!2.05e-35!140;CL:0002087!7.54e-30!119;CL:0002031!4.64e-29!124;CL:0000037!4.71e-27!172;CL:0000566!4.71e-27!172;CL:0000988!2.95e-26!182;CL:0002032!7.06e-25!165;CL:0000837!7.06e-25!165;CL:0002057!1.35e-24!42;CL:0000860!3.93e-23!45;CL:0000766!8.85e-20!76;CL:0000557!2.59e-18!71;CL:0002009!2.51e-16!65;CL:0002194!2.33e-15!63;CL:0000576!2.33e-15!63;CL:0000040!2.33e-15!63;CL:0000559!2.33e-15!63;CL:0000839!2.46e-15!70;CL:0000542!6.83e-13!53;CL:0000051!6.83e-13!53;CL:0000838!1.21e-12!52;CL:0000763!2.05e-12!112;CL:0000049!2.05e-12!112;CL:0002320!5.84e-12!365;CL:0000134!9.91e-12!358;CL:0000219!6.64e-09!390;CL:0002393!4.58e-07!9;CL:0002397!4.58e-07!9;CL:0000003!5.50e-07!722;CL:0000236!9.00e-07!14
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!1.30e-18!102;UBERON:0003061!1.30e-18!102;UBERON:0001474!2.90e-18!86;UBERON:0002371!2.20e-17!80;UBERON:0002193!1.05e-14!112;UBERON:0004765!5.86e-14!101;UBERON:0001434!5.86e-14!101;UBERON:0002384!1.13e-11!375;UBERON:0002405!1.51e-09!115
}}

Latest revision as of 11:59, 17 September 2013


Full id: C2144_Basophils_CD14_Eosinophils_CD4_CD19_Natural_Mast



Phase1 CAGE Peaks

Hg19::chr11:62323170..62323185,+p@chr11:62323170..62323185
+
Hg19::chr12:13254352..13254403,+p@chr12:13254352..13254403
+
Hg19::chr1:156076341..156076364,+p22@LMNA
Hg19::chr8:145026443..145026482,+p@chr8:145026443..145026482
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte8.32e-39136
hematopoietic stem cell1.45e-33168
angioblastic mesenchymal cell1.45e-33168
hematopoietic cell8.38e-33177
nongranular leukocyte5.93e-31115
hematopoietic lineage restricted progenitor cell8.19e-31120
classical monocyte9.17e-3142
CD14-positive, CD16-negative classical monocyte9.17e-3142
hematopoietic oligopotent progenitor cell1.39e-30161
hematopoietic multipotent progenitor cell1.39e-30161
myeloid leukocyte2.31e-2672
defensive cell9.54e-2648
phagocyte9.54e-2648
granulocyte monocyte progenitor cell4.36e-2467
macrophage dendritic cell progenitor1.68e-2161
myeloid lineage restricted progenitor cell7.91e-2166
myeloid cell2.55e-20108
common myeloid progenitor2.55e-20108
monopoietic cell3.18e-2059
monocyte3.18e-2059
monoblast3.18e-2059
promonocyte3.18e-2059
connective tissue cell1.70e-16361
mesenchymal cell4.88e-16354
motile cell2.99e-12386
stuff accumulating cell3.50e-1087
lymphocyte1.32e-0953
common lymphoid progenitor1.32e-0953
lymphoid lineage restricted progenitor cell2.61e-0952
nucleate cell8.61e-0955
multi fate stem cell9.53e-09427
stem cell1.17e-08441
intermediate monocyte1.35e-089
CD14-positive, CD16-positive monocyte1.35e-089
somatic stem cell1.87e-08433
Uber Anatomy
Ontology termp-valuen
bone element5.82e-2582
bone marrow9.12e-2476
skeletal element5.84e-2390
hematopoietic system2.33e-2298
blood island2.33e-2298
skeletal system5.45e-19100
hemolymphoid system3.81e-18108
immune system1.15e-1793
connective tissue7.90e-16371
lateral plate mesoderm7.45e-07203


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.05935
MA0004.10.71247
MA0006.12.26728
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.15.62637
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.12.00595
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.12.41215
MA0146.11.25938
MA0147.12.03364
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.52211
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.21.79838
MA0047.20.856092
MA0112.20.551048
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.11.37853
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.21.6798
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360116317477163
BCL11A#53335214.18472755180350.007108328585298740.0296125540135626
BCL3#602217.27355140186920.004834494208076070.0226691393434767
EBF1#187936.679850134926750.005184294118278910.0240320680612042
ELF1#199744.258097958807540.003041525565781240.0160552887826448
EP300#203335.08045629466740.01144298405398240.041869944000766
IRF4#3662210.95725634337210.01174530180688030.0428141277934025
MAX#414946.452555509007120.0005767613195645490.00484487858553864
MXI1#460137.471178721569470.003741314738550960.0186217018529058
NR3C1#2908311.22976749837980.001131672068063850.00775224315338586
PAX5#507935.002174148383370.01196533174786410.0434720407157579
POU2F2#545236.829593043306890.004860473775203740.0227521411235939
RXRA#6256210.03730856956660.01391703805920110.0488696637033455



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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