Coexpression cluster:C3633

Full id: C3633_testicular_large_melanoma_papillary_osteosarcoma_Trabecular_gastric

Phase1 CAGE Peaks

Hg19::chr17:41622834..41622883,-	p6@ETV4
Hg19::chr17:41622901..41622913,-	p16@ETV4
Hg19::chr17:41622925..41622976,-	p3@ETV4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.17e-35	254
embryonic cell	5.12e-27	248
animal cell	3.73e-15	679
eukaryotic cell	3.73e-15	679
mesodermal cell	5.39e-12	119
squamous epithelial cell	2.93e-10	62
endodermal cell	1.06e-09	59
blood vessel endothelial cell	1.67e-09	18
embryonic blood vessel endothelial progenitor cell	1.67e-09	18
endothelial cell of vascular tree	1.95e-08	24
meso-epithelial cell	5.10e-08	44
non-terminally differentiated cell	1.20e-07	180
endothelial cell	2.12e-07	35
native cell	2.15e-07	722
endo-epithelial cell	3.61e-07	43
lining cell	5.92e-07	57
barrier cell	5.92e-07	57

Uber Anatomy

Ontology term	p-value	n
epithelial tube	9.75e-17	118
unilaminar epithelium	2.55e-15	138
mesenchyme	1.52e-14	238
entire embryonic mesenchyme	1.52e-14	238
cell layer	2.24e-14	312
epithelium	1.39e-13	309
vasculature	2.89e-12	79
vascular system	2.89e-12	79
trunk mesenchyme	4.24e-12	143
trunk	9.19e-12	216
endoderm-derived structure	9.28e-12	169
endoderm	9.28e-12	169
presumptive endoderm	9.28e-12	169
multi-tissue structure	1.06e-11	347
vessel	1.61e-11	69
primordium	3.03e-11	168
blood vessel	7.88e-11	60
epithelial tube open at both ends	7.88e-11	60
blood vasculature	7.88e-11	60
vascular cord	7.88e-11	60
immaterial anatomical entity	3.87e-10	126
splanchnic layer of lateral plate mesoderm	6.44e-10	84
artery	1.62e-09	42
arterial blood vessel	1.62e-09	42
arterial system	1.62e-09	42
endothelium	1.67e-09	18
blood vessel endothelium	1.67e-09	18
cardiovascular system endothelium	1.67e-09	18
digestive system	3.66e-09	155
digestive tract	3.66e-09	155
primitive gut	3.66e-09	155
simple squamous epithelium	3.93e-09	22
mixed endoderm/mesoderm-derived structure	4.71e-09	130
anatomical conduit	1.06e-08	241
anatomical cluster	1.18e-08	286
squamous epithelium	2.74e-08	25
anatomical space	6.12e-08	104
endo-epithelium	8.29e-08	82
multilaminar epithelium	1.04e-07	82
trunk region element	1.40e-07	107
cardiovascular system	1.46e-07	110
organism subdivision	2.14e-07	365
systemic artery	6.46e-07	33
systemic arterial system	6.46e-07	33
circulatory system	6.86e-07	113

Disease

Ontology term	p-value	n
carcinoma	1.94e-11	106
cell type cancer	5.00e-10	143
disease of cellular proliferation	1.11e-09	239
cancer	1.86e-09	235

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.