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Coexpression cluster:C2481: Difference between revisions

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|full_id=C2481_Mast_Neutrophils_blood_lung_Natural_CD8_penis
|full_id=C2481_Mast_Neutrophils_blood_lung_Natural_CD8_penis
|id=C2481
|id=C2481
|ontology_enrichment_celltype=CL:0000738!1.41e-13!140;CL:0002087!1.23e-11!119;CL:0000791!7.81e-11!18;CL:0000789!7.81e-11!18;CL:0002420!7.81e-11!18;CL:0002419!7.81e-11!18;CL:0000790!7.81e-11!18;CL:0002057!1.07e-10!42;CL:0002031!1.64e-10!124;CL:0000860!2.73e-09!45;CL:0000766!3.90e-08!76;CL:0000838!2.61e-07!52;CL:0000625!2.82e-07!11;CL:0000084!3.22e-07!25;CL:0000827!3.22e-07!25;CL:0000542!3.54e-07!53;CL:0000051!3.54e-07!53
|ontology_enrichment_celltype=CL:0000738!6.26e-17!136;CL:0002087!2.59e-15!115;CL:0002031!1.59e-13!120;CL:0000791!9.13e-12!18;CL:0000789!9.13e-12!18;CL:0002420!9.13e-12!18;CL:0002419!9.13e-12!18;CL:0000790!9.13e-12!18;CL:0000766!3.64e-10!72;CL:0000860!1.00e-09!42;CL:0002057!1.00e-09!42;CL:0000838!1.22e-09!52;CL:0000542!3.65e-09!53;CL:0000051!3.65e-09!53;CL:0000084!1.03e-08!25;CL:0000827!1.03e-08!25;CL:0002242!2.78e-08!55;CL:0000625!6.90e-08!11;CL:0000037!1.36e-07!168;CL:0000566!1.36e-07!168;CL:0002032!1.72e-07!161;CL:0000837!1.72e-07!161;CL:0000094!3.10e-07!8;CL:0000988!6.77e-07!177;CL:0000473!7.01e-07!48;CL:0000234!7.01e-07!48
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0003081!4.95e-09!216;UBERON:0007023!3.48e-08!115;UBERON:0002390!2.09e-07!102;UBERON:0003061!2.09e-07!102;UBERON:0002193!2.80e-07!112
|ontology_enrichment_uberon=UBERON:0003081!8.19e-10!203;UBERON:0002390!2.11e-08!98;UBERON:0003061!2.11e-08!98;UBERON:0002193!2.20e-08!108;UBERON:0007023!2.57e-08!114
|tf_chipseq_enrich=CTCFL#140690;3:14.8098557692308:0.000499629176756334:0.0044086491712787!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101443547276384!ZBTB7A#51341;3:5.51393198090692:0.00903835282108109:0.0342447498741479
|tf_chipseq_enrich=CTCFL#140690;3:14.8098557692308:0.000499629176756334:0.0044086491712787!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101443547276384!ZBTB7A#51341;3:5.51393198090692:0.00903835282108109:0.0342447498741479
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069,0.0104244,0.0752771,0.178782,0.019419,0.0866228,0.271849,0.282657,0.105411,0.0997542,0.209692,0.248936,0.0725263,0.102587,0.0742013,0.0552936,0.0457886,0.0514927,0.324236,0.220368,0.258624,0.064656,0.226143,0.000447146,0.0438521,0.435508,0.281453,0.0522771,0.0787278,0.164404,0.159873,0.142462,0.143935,0.332403,0.0379537,1.62987e-09,0.187953,0.051459,0.114868,0.0726892,0.18732,0.32305,0.278397,0.245002,0.170848,0.144756,0.302909,0.363016,0.100188,0.223102,0.107653,0.235857,0.103852,0.191914,0.184022,0.216557,0.182956,0.116818,0.389792,0.36316,0.0625685,0.124464,0.00130916,0.0159364,0.101893,0.142875,0.167635,0.171311,0.20386,0.189107,0.0685131,0.130287,0.0661526,0.0815772,0.0993937,0.122878,0.187329,0.0451012,0.0976639,0.00103527,0.107849,0.758305,0.278645,0.0769795,0.0128057,0.248017,0.22995,0.00463504,0.0760151,0.0629459,6.84901e-05,0.0803251,0.226641,0.379174,0.0939463,0.286748,0.367925,0.0471607,0.163865,0.226359,0.00605585,1.68094e-06,0.265324,0.279778,0.141699,0.0887743,0.142302,0.0653269,0.125712,0.264432,0.0994829,0.0604041,0.144185,0.0925862,0.00516485,0.199201,0.049937,0.172796,0.0595495,0.071232,0.149346,0.121978,0.22302,0.137423,0.284016,0.0754883,0.299492,0.100006,0.0756617,0.197817,0.0345492,0.00462092,0.133127,0.410303,0.223717,0.0189842,0.196838,0.0826805,0.246601,0.0199582,0.000422824,0.202165,0.0946865,0.120618,0.079499,0.18762,0.195618,0.127688,0.201169,0.220353,0.24948,0.178639,0.291976,0.320355,0.364334,0.15547,0.110256,0.415419,0.14794,0.147307,0.240761,0.225961,0.124417,0.335582,0.317428,0.182843,0.130771,0.000756078,0.135777,0.147842,0.0339286,0.0255494,0.119015,0.690952,0.21618,0.243266,0.107021,0.238657,0.20272,0.392453,0.0164195,0.0780061,0.00683871,0.230477,0.279823,0.0487563,0.00567943,0.0103352,0.0478217,0.00599702,0.170854,0.0575231,0.174063,0.163504,0.459091,0.54832,0.502211,0.296013,0.649813,0.537932,0.459994,0.523209,0.0465928,0.25423,0.490559,0.45013,0.500698,0.472542,0.111549,0.747471,0.529642,0.818701,0.14198,0.590496,0.0671621,0.0446875,0.627201,0.0635843,2.12301e-07,0.290703,0.017476,0.722684,0.478691,0.360199,0.0153629,0.290133,0.253797,0.365494,0.212703,0.0102049,0.364079,0.315494,0.215551,0.421038,0.569409,0.328518,0.545608,0.310552,0.324103,0.0295909,0.00961647,0.784052,0.209437,0.00302432,0.00298496,0.232518,0.00647536,0.12974,0.152018,0.579004,0.0565519,0.0387841,0.315519,0.0376583,0.257956,0.264245,0.379063,0.0602936,0.522925,0.436016,0.475063,0.202522,0.183837,0.507324,0.0083072,0.3955,0.442469,0.212239,0.294954,0.156999,0.0742603,0.000150432,0.39549,0.234254,0.357409,0.599068,0.721266,0.50338,0.620526,0.404625,0.000684584,0.424691,0.715362,0.479581,0.62689,0.172925,0.274432,0.284496,0.512545,0.512178,0.563206,0.260945,0.321001,0.263302,0.552023,0.180735,0.000899481,0.216102,0.254659,0.109605,0.00184531,0.0121932,0.226491,0.417131,0.463987,0.0782409,0.000790209,0.454761,0.639483,0.00471559,0.452129,0.301581,0.261657,0.346776,0.466529,0.0458396,0.438176,0.349112,0.741477,0.385425,0.307816,0.461541,0.386339,0.382854,0.598787,0.478745,0.611661,0.319747,0.475047,0.557967,0.0153563,0.282281,0.612712,0.2536,0.246827,0.202347,0.70712,0.387134,0.198743,0.358813,0.303004,0.574252,0.493455,0.346636,0.457747,0.348802,0.476541,0.579645,0.447581,0.42505,0.254628,0.713293,0.479347,0.416962,0.632833,0.378333,0.152547,0.0384092,0.22798,0.102495,0.350933,0.263896,0.0446972,0.24452,0.329284,0.242783,0.0947248,0.336551,0.210656,0.246234,0.211271,0.281295,0.267248,0.118257,0.125087,0.215123,0.321224,0.469461,0.325254,0.266651,0.546295,0.231754,0.249415,0.283107,0.285648,0.427316,0.391071,0.279553,0.25563,0.240967,0.160955,0.256687,0.0432189,0.00782177,0.0138731,0.23235,0.290415,0.353147,0.112422,0.170886,0.00399713,0.315656,0.00489571,0.0887542,0.267811,0.338547,0.147872,0.189388,0.293546,0.210125,0.0478543,0.218414,0.0509944,0.0871471,0.0689852,0.0602698,0.341188,0.259328,0.437467,0.201057,0.15696,0.129351,0.000533222,0.0786166,0.276997,0.205513,0.282389,0.251421,0.162089,0.330223,0.387837,0.233244,0.207281,0.000752253,0.195748,0.0429696,0.161712,0.237871,0.239139,0.095257,0.328852,0.332769,0.262022,0.274403,0.266687,0.184534,0.248707,0.31749,0.15156,0.287598,0.313858,0.223773,0.036547,0.00116104,0.253768,0.30702,0.202977,0.170837,0.327002,0.28543,0.222656,0.228479,0.127111,0.259989,0.390754,0.355805,0.279739,0.108118,0.259901,0.139723,0.0708274,0.0710478,0.196248,0.102645,0.0539258,0.0709978,0.401939,0.332746,0.271338,0.032013,0.298673,0.244395,0.106889,0.128632,0.0845989,0.159153,0.0842401,0.13698,0.0874421,0.100355,0.167854,0.000543954,0.0583767,0.000122691,0.117657,0.0486914,0.00104239,0.262778,0.373453,0.362662,0.111581,0.184359,0.334474,0.325785,0.257476,0.291176,0.376537,0.322827,0.229571,0.359036,0.335984,0.171704,0.208256,0.265058,0.256405,0.362898,0.302133,0.40806,0.151361,0.279606,0.286696,0.150674,0.251128,0.246177,0.35674,0.0104945,0.0571822,0.213257,0.287217,0.00786668,0.410951,0.289049,0.00396262,0.125746,0.112897,0.398354,0.222091,0.205977,0.34423,0.0936726,0.3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}}
}}

Revision as of 14:04, 19 October 2012


Full id: C2481_Mast_Neutrophils_blood_lung_Natural_CD8_penis



Phase1 CAGE Peaks

Hg19::chr19:16435735..16435773,+p4@KLF2
Hg19::chr19:16436139..16436182,+p@chr19:16436139..16436182
+
Hg19::chr19:16436186..16436202,+p@chr19:16436186..16436202
+
Hg19::chr19:16436441..16436460,+p@chr19:16436441..16436460
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte6.26e-17136
nongranular leukocyte2.59e-15115
hematopoietic lineage restricted progenitor cell1.59e-13120
mature alpha-beta T cell9.13e-1218
alpha-beta T cell9.13e-1218
immature T cell9.13e-1218
mature T cell9.13e-1218
immature alpha-beta T cell9.13e-1218
myeloid leukocyte3.64e-1072
classical monocyte1.00e-0942
CD14-positive, CD16-negative classical monocyte1.00e-0942
lymphoid lineage restricted progenitor cell1.22e-0952
lymphocyte3.65e-0953
common lymphoid progenitor3.65e-0953
T cell1.03e-0825
pro-T cell1.03e-0825
nucleate cell2.78e-0855
CD8-positive, alpha-beta T cell6.90e-0811
hematopoietic stem cell1.36e-07168
angioblastic mesenchymal cell1.36e-07168
hematopoietic oligopotent progenitor cell1.72e-07161
hematopoietic multipotent progenitor cell1.72e-07161
granulocyte3.10e-078
hematopoietic cell6.77e-07177
defensive cell7.01e-0748
phagocyte7.01e-0748
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm8.19e-10203
hematopoietic system2.11e-0898
blood island2.11e-0898
hemolymphoid system2.20e-08108
adult organism2.57e-08114


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCFL#140690314.80985576923080.0004996291767563340.0044086491712787
EGR1#195844.988179094810140.001615011500076050.0101443547276384
ZBTB7A#5134135.513931980906920.009038352821081090.0342447498741479



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.