Coexpression cluster:C1312

Full id: C1312_Eosinophils_Basophils_CD4_Natural_Mast_granulocyte_CD14CD16

Phase1 CAGE Peaks

Hg19::chr10:43932190..43932234,-	p@chr10:43932190..43932234 -
Hg19::chr12:111028863..111028911,+	p@chr12:111028863..111028911 +
Hg19::chr15:66084828..66084847,+	p@chr15:66084828..66084847 +
Hg19::chr1:150980668..150980692,-	p11@FAM63A
Hg19::chr2:86669343..86669357,-	p@chr2:86669343..86669357 -
Hg19::chr3:53926081..53926105,+	p@chr3:53926081..53926105 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
leukocyte	6.29e-57	136
hematopoietic stem cell	1.68e-48	168
angioblastic mesenchymal cell	1.68e-48	168
hematopoietic cell	2.51e-45	177
hematopoietic oligopotent progenitor cell	5.39e-45	161
hematopoietic multipotent progenitor cell	5.39e-45	161
nongranular leukocyte	5.41e-45	115
hematopoietic lineage restricted progenitor cell	2.06e-43	120
classical monocyte	3.16e-31	42
CD14-positive, CD16-negative classical monocyte	3.16e-31	42
myeloid leukocyte	5.29e-29	72
defensive cell	6.36e-25	48
phagocyte	6.36e-25	48
granulocyte monocyte progenitor cell	2.30e-24	67
myeloid cell	2.86e-23	108
common myeloid progenitor	2.86e-23	108
macrophage dendritic cell progenitor	8.71e-23	61
monopoietic cell	1.19e-21	59
monocyte	1.19e-21	59
monoblast	1.19e-21	59
promonocyte	1.19e-21	59
myeloid lineage restricted progenitor cell	2.45e-21	66
lymphocyte	1.82e-20	53
common lymphoid progenitor	1.82e-20	53
lymphoid lineage restricted progenitor cell	5.45e-20	52
nucleate cell	4.42e-19	55
mesenchymal cell	1.22e-14	354
connective tissue cell	1.52e-14	361
motile cell	3.30e-13	386
mature alpha-beta T cell	6.81e-12	18
alpha-beta T cell	6.81e-12	18
immature T cell	6.81e-12	18
mature T cell	6.81e-12	18
immature alpha-beta T cell	6.81e-12	18
B cell	9.59e-10	14
lymphocyte of B lineage	1.21e-09	24
pro-B cell	1.21e-09	24
T cell	2.92e-09	25
pro-T cell	2.92e-09	25
stuff accumulating cell	8.39e-09	87
intermediate monocyte	1.55e-08	9
CD14-positive, CD16-positive monocyte	1.55e-08	9
granulocyte	1.73e-08	8
CD4-positive, alpha-beta T cell	5.94e-07	6
CD8-positive, alpha-beta T cell	9.60e-07	11

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.54e-29	98
blood island	1.54e-29	98
hemolymphoid system	7.58e-25	108
bone marrow	4.96e-22	76
bone element	1.84e-20	82
immune system	1.14e-19	93
skeletal element	5.43e-18	90
skeletal system	4.51e-14	100
connective tissue	1.09e-13	371

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ELF1#1997	5	3.54841496567295	0.00344683777572169	0.0175225998081483
ELK4#2005	3	8.11784082923401	0.00405611313418576	0.0194061294434572
GABPB1#2553	4	4.71178922412145	0.00473005431155596	0.0222844705090488
IRF1#3659	4	5.09144250237593	0.00353524076589381	0.0179423175405376
MAX#4149	4	4.30170367267141	0.00664492391067637	0.0282914475461528
NANOG#79923	3	14.6223892405063	0.00073945629288338	0.00582501702914824
NFE2#4778	2	25.734753550543	0.00242996970902926	0.0136884361618828
PAX5#5079	4	4.44637702078522	0.00587473351924079	0.0263564282836887
POLR2A#5430	6	2.14745317655807	0.0101957067681878	0.0379834992923866
RFX5#5993	4	8.0319405514634	0.000620461542838141	0.00510923149668632
SIN3A#25942	5	4.50740393901261	0.00109611006120864	0.00765781247458484
SMARCB1#6598	3	9.12635789057871	0.00290024715036702	0.0156747522323112
SPI1#6688	5	6.83693625710227	0.000144964177397403	0.00188541889454638
TAF1#6872	5	2.78587190478774	0.0107863634029041	0.0397837620933711
TBP#6908	5	3.08897557258032	0.00664544827578693	0.0282786934146156
THAP1#55145	2	10.4563815342838	0.0139914785110365	0.0491161985887582
USF1#7391	4	4.24099951813864	0.00700536775082942	0.0295980259124104
ZNF143#7702	3	6.75043827611395	0.00685025920446858	0.0290331231659563
ZNF263#10127	4	5.48122775800712	0.00267560938060723	0.0147413994567017

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.