MCL coexpression mm9:258

Phase1 CAGE Peaks

	Short description
Mm9::chr10:115614273..115614299,+	p17@Ptprr
Mm9::chr10:59794676..59794683,-	p8@Cdh23
Mm9::chr10:60760547..60760556,+	p3@Prf1
Mm9::chr10:60760557..60760572,+	p1@Prf1
Mm9::chr11:54716349..54716360,+	p2@Gpx3
Mm9::chr12:112687835..112687862,+	p2@Tnfaip2
Mm9::chr13:20203373..20203384,+	p22@Elmo1
Mm9::chr14:100158827..100158833,+	p@chr14:100158827..100158833 +
Mm9::chr14:56739460..56739464,-	p2@Gzme
Mm9::chr14:56751427..56751432,-	p1@Gzmd p1@Gzme
Mm9::chr14:56778427..56778434,-	p1@Gzmg
Mm9::chr14:56830260..56830267,-	p1@Gzmf
Mm9::chr14:56853487..56853492,-	p1@Gzmc p2@Gzmf
Mm9::chr14:56857569..56857584,-	p@chr14:56857569..56857584 -
Mm9::chr14:56881009..56881024,-	p2@Gzmb
Mm9::chr14:56881070..56881085,-	p1@Gzmb
Mm9::chr14:63810770..63810774,-	p@chr14:63810770..63810774 -
Mm9::chr1:12980554..12980563,-	p4@Slco5a1
Mm9::chr1:154974262..154974286,-	p@chr1:154974262..154974286 -
Mm9::chr1:174532650..174532675,-	p1@Fcrl6
Mm9::chr1:174532686..174532697,-	p2@Fcrl6
Mm9::chr1:36700822..36700853,-	p@chr1:36700822..36700853 -
Mm9::chr1:95616230..95616234,+	p@chr1:95616230..95616234 +
Mm9::chr2:124475078..124475084,+	p@chr2:124475078..124475084 +
Mm9::chr2:26526838..26526843,-	p1@Lcn4
Mm9::chr3:69400164..69400168,-	p@chr3:69400164..69400168 -
Mm9::chr4:19849746..19849761,-	p2@Atp6v0d2
Mm9::chr6:122232828..122232839,-	p1@Klrg1
Mm9::chr7:121714477..121714501,+	p@chr7:121714477..121714501 +
Mm9::chr7:129057811..129057817,+	p@chr7:129057811..129057817 +
Mm9::chr9:108382273..108382282,+	p3@Lamb2
Mm9::chr9:21574303..21574331,-	p@chr9:21574303..21574331 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019835	cytolysis	2.53419807642747e-14
GO:0004252	serine-type endopeptidase activity	2.59989400226143e-06
GO:0017171	serine hydrolase activity	2.59989400226143e-06
GO:0008236	serine-type peptidase activity	2.59989400226143e-06
GO:0005615	extracellular space	3.26456462623991e-06
GO:0008219	cell death	3.96799342549326e-06
GO:0044421	extracellular region part	3.96799342549326e-06
GO:0016265	death	3.96799342549326e-06
GO:0048468	cell development	1.75622708928195e-05
GO:0048869	cellular developmental process	4.46779780721031e-05
GO:0030154	cell differentiation	4.46779780721031e-05
GO:0004175	endopeptidase activity	6.86183091701417e-05
GO:0006508	proteolysis	0.00052187985334583
GO:0008233	peptidase activity	0.000803721231104847
GO:0032502	developmental process	0.00322055582686556
GO:0005605	basal lamina	0.00569053171091571
GO:0016787	hydrolase activity	0.00923687981078232
GO:0004278	granzyme B activity	0.014416808195913
GO:0032426	stereocilium bundle tip	0.014416808195913
GO:0008626	induction of apoptosis by granzyme	0.014416808195913
GO:0005201	extracellular matrix structural constituent	0.0231198544623718
GO:0005604	basement membrane	0.0235484112202604
GO:0001917	photoreceptor inner segment	0.0332367573478983
GO:0043259	laminin-10 complex	0.0332367573478983
GO:0044420	extracellular matrix part	0.0416924805907267
GO:0048563	post-embryonic organ morphogenesis	0.0479613305053664
GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	0.0479613305053664
GO:0060013	righting reflex	0.0479613305053664

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
extraembryonic membrane	6.04e-65	3
extraembryonic structure	6.04e-65	3
membranous layer	6.04e-65	3
embryonic uterus	1.60e-49	4
uterus	1.60e-49	4
placenta	4.55e-44	2
chorion	4.55e-44	2
allantois	4.55e-44	2
internal female genitalia	7.27e-40	5
female reproductive organ	2.39e-25	8
uterus or analog	3.06e-23	1
internal genitalia	1.19e-22	9
female reproductive system	1.19e-22	9
amnion	1.39e-22	1
female organism	1.00e-18	11
reproductive organ	4.35e-09	24
organ component layer	5.26e-09	24
reproductive structure	1.87e-08	26
reproductive system	1.87e-08	26
somatic layer of lateral plate mesoderm	1.88e-08	3
adult organism	1.20e-07	51

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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