MCL coexpression mm9:479

Phase1 CAGE Peaks

	Short description
Mm9::chr10:24562097..24562114,+	p@chr10:24562097..24562114 +
Mm9::chr11:83664365..83664383,+	p1@Hnf1b
Mm9::chr11:83666422..83666446,+	p4@Hnf1b
Mm9::chr12:25367561..25367565,+	p@chr12:25367561..25367565 +
Mm9::chr13:73484734..73484745,-	p3@D630045M09Rik
Mm9::chr13:98786218..98786238,-	p7@Rgnef
Mm9::chr1:20157166..20157171,-	p@chr1:20157166..20157171 -
Mm9::chr1:20501784..20501787,-	p@chr1:20501784..20501787 -
Mm9::chr1:20576990..20576994,-	p@chr1:20576990..20576994 -
Mm9::chr1:20608054..20608071,-	p2@Pkhd1
Mm9::chr1:20608073..20608170,-	p1@Pkhd1
Mm9::chr1:20608173..20608178,-	p3@Pkhd1
Mm9::chr4:155458412..155458438,-	p@chr4:155458412..155458438 -
Mm9::chr5:103197888..103197908,+	p2@Arhgap24
Mm9::chr6:38933302..38933316,+	p3@Tbxas1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004796	thromboxane-A synthase activity	0.0259232866376788
GO:0048731	system development	0.0259232866376788
GO:0048856	anatomical structure development	0.0259232866376788
GO:0001826	inner cell mass cell differentiation	0.0259232866376788
GO:0007275	multicellular organismal development	0.0259232866376788
GO:0048646	anatomical structure formation	0.0259232866376788
GO:0009746	response to hexose stimulus	0.0259232866376788
GO:0009743	response to carbohydrate stimulus	0.0259232866376788
GO:0009749	response to glucose stimulus	0.0259232866376788
GO:0001825	blastocyst formation	0.0291605017960454
GO:0007417	central nervous system development	0.0294311949806488
GO:0009653	anatomical structure morphogenesis	0.0294311949806488
GO:0046457	prostanoid biosynthetic process	0.0294311949806488
GO:0001516	prostaglandin biosynthetic process	0.0294311949806488
GO:0032502	developmental process	0.0294311949806488
GO:0021955	central nervous system neuron axonogenesis	0.0294311949806488
GO:0060052	neurofilament cytoskeleton organization and biogenesis	0.0294311949806488
GO:0030695	GTPase regulator activity	0.0294311949806488
GO:0048513	organ development	0.0360718416571888
GO:0006693	prostaglandin metabolic process	0.0360718416571888
GO:0006692	prostanoid metabolic process	0.0360718416571888
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	0.04305018068093
GO:0007492	endoderm development	0.04305018068093
GO:0051271	negative regulation of cell motility	0.043678484892207
GO:0040013	negative regulation of locomotion	0.0442560147190313
GO:0045103	intermediate filament-based process	0.0447062043621739
GO:0021954	central nervous system neuron development	0.0447062043621739
GO:0030073	insulin secretion	0.0447062043621739
GO:0046456	icosanoid biosynthetic process	0.0447062043621739
GO:0021953	central nervous system neuron differentiation	0.0447062043621739
GO:0048869	cellular developmental process	0.0447062043621739
GO:0030154	cell differentiation	0.0447062043621739
GO:0030072	peptide hormone secretion	0.0474422975110747
GO:0002790	peptide secretion	0.0474422975110747
GO:0010033	response to organic substance	0.0474422975110747
GO:0006690	icosanoid metabolic process	0.0474422975110747
GO:0050673	epithelial cell proliferation	0.0474422975110747
GO:0001824	blastocyst development	0.0474422975110747
GO:0032501	multicellular organismal process	0.0497068242388782

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk region element	2.77e-16	79
kidney	7.48e-15	14
kidney mesenchyme	7.48e-15	14
upper urinary tract	7.48e-15	14
kidney rudiment	7.48e-15	14
kidney field	7.48e-15	14
pancreas	3.31e-14	12
trunk	1.11e-12	90
urinary system structure	4.21e-12	18
renal system	3.24e-11	19
cavitated compound organ	1.04e-09	21
immaterial anatomical entity	7.16e-09	79
viscus	8.02e-09	19
abdomen element	2.23e-08	49
abdominal segment element	2.23e-08	49
abdominal segment of trunk	2.23e-08	49
abdomen	2.23e-08	49
body cavity precursor	1.12e-07	38
anatomical cavity	2.48e-07	39
subdivision of trunk	2.83e-07	66
body cavity	5.45e-07	37
body cavity or lining	5.45e-07	37

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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