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Coexpression cluster:C1299

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Full id: C1299_chronic_acute_chorionic_leukemia_choriocarcinoma_pancreatic_placenta



Phase1 CAGE Peaks

Hg19::chr10:11936692..11936705,-p1@ENST00000445498
p1@uc001iky.1
Hg19::chr11:64937702..64937707,+p1@SPDYC
Hg19::chr2:12417696..12417715,-p@chr2:12417696..12417715
-
Hg19::chr2:15696037..15696048,-p@chr2:15696037..15696048
-
Hg19::chr8:129061640..129061667,+p@chr8:129061640..129061667
+
Hg19::chr8:129061678..129061731,+p@chr8:129061678..129061731
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0019901protein kinase binding0.0189420699399505
GO:0019900kinase binding0.0189420699399505
GO:0019899enzyme binding0.0389045880921543



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
myeloid cell7.27e-46112
common myeloid progenitor7.27e-46112
hematopoietic stem cell1.62e-36172
angioblastic mesenchymal cell1.62e-36172
hematopoietic cell3.95e-36182
hematopoietic oligopotent progenitor cell8.55e-36165
hematopoietic multipotent progenitor cell8.55e-36165
myeloid leukocyte7.95e-3276
myeloid lineage restricted progenitor cell1.62e-3170
granulocyte monocyte progenitor cell2.80e-3071
macrophage dendritic cell progenitor4.01e-2765
CD14-positive, CD16-negative classical monocyte9.68e-2742
monopoietic cell3.30e-2663
monocyte3.30e-2663
monoblast3.30e-2663
promonocyte3.30e-2663
classical monocyte1.17e-2345
leukocyte5.34e-23140
hematopoietic lineage restricted progenitor cell3.47e-22124
nongranular leukocyte5.88e-19119
intermediate monocyte9.81e-089
CD14-positive, CD16-positive monocyte9.81e-089
Uber Anatomy
Ontology termp-valuen
hematopoietic system6.23e-32102
blood island6.23e-32102
hemolymphoid system6.24e-27112
bone marrow7.16e-2480
bone element4.13e-2186
immune system7.35e-19115
lateral plate mesoderm6.25e-18216
skeletal element2.13e-14101
skeletal system2.13e-14101
blood2.73e-0915
haemolymphatic fluid2.73e-0915
organism substance2.73e-0915
Disease
Ontology termp-valuen
myeloid leukemia1.79e-1631
leukemia2.67e-1339
hematologic cancer1.06e-0951
immune system cancer1.06e-0951


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.