MCL coexpression mm9:3680

Phase1 CAGE Peaks

	Short description
Mm9::chr8:63462012..63462116,-	p1@Clcn3
Mm9::chr9:77956395..77956423,-	p2@Fbxo9
Mm9::chr9:77956424..77956457,-	p1@Fbxo9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005247	voltage-gated chloride channel activity	0.0413509070568605
GO:0022844	voltage-gated anion channel activity	0.0413509070568605
GO:0016567	protein ubiquitination	0.0413509070568605
GO:0000151	ubiquitin ligase complex	0.0413509070568605
GO:0032446	protein modification by small protein conjugation	0.0413509070568605
GO:0043168	anion binding	0.0413509070568605
GO:0031404	chloride ion binding	0.0413509070568605
GO:0005254	chloride channel activity	0.0413509070568605
GO:0006821	chloride transport	0.0413509070568605
GO:0005253	anion channel activity	0.0413509070568605

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anatomical conduit	1.00e-09	122
tube	7.09e-09	114
organ system subdivision	1.03e-08	194
regional part of nervous system	1.07e-08	54
exocrine gland	1.95e-08	25
exocrine system	1.95e-08	25
neural tube	9.47e-08	52
neural rod	9.47e-08	52
future spinal cord	9.47e-08	52
neural keel	9.47e-08	52
liver	1.18e-07	22
epithelial sac	1.18e-07	22
digestive gland	1.18e-07	22
epithelium of foregut-midgut junction	1.18e-07	22
anatomical boundary	1.18e-07	22
hepatobiliary system	1.18e-07	22
foregut-midgut junction	1.18e-07	22
hepatic diverticulum	1.18e-07	22
liver primordium	1.18e-07	22
septum transversum	1.18e-07	22
liver bud	1.18e-07	22
adult organism	1.30e-07	51
gray matter	1.71e-07	34
central nervous system	1.98e-07	73
digestive tract diverticulum	2.20e-07	23
sac	2.20e-07	23
occipital lobe	6.32e-07	10
visual cortex	6.32e-07	10
neocortex	6.32e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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